Navigation Links
Knockout of protein prevents colon tumor formation in mice
Date:9/29/2011

A protein that regulates cell differentiation in normal tissue may play a different role in colon and breast cancer, activating proliferation of damaged cells, according to researchers at the University of Illinois at Chicago College of Medicine.

The protein, called PTK6, is found in normal skin and gut cells -- and in cancerous, but not normal, breast tissue.

"Our research has primarily focused on the normal function of this protein in the gut, where it regulates growth and differentiation," said Angela Tyner, professor of biochemistry and molecular genetics.

Epithelial cells, such as skin cells and the cells that line the colon, turn over rapidly. To replace them, new cells must be continuously produced that become specialized, or differentiated, to perform specific functions.

To further their investigation of PTK6, Tyner and her colleagues developed a mouse that lacked the PTK6 gene. Based on their observation of increased growth in the intestine, Tyner's group suspected that mice lacking PTK6 would be more susceptible to cancer.

Using a carcinogen, the researchers induced colon tumors resembling human sporadic colon cancer in mice lacking the PTK6 gene and in normal mice.

"Mice lacking PTK6 were highly resistant to the carcinogen and developed fewer tumors," Tyner said. "It was an unexpected result."

Tyner and her colleagues were able to establish the reason for this unexpected result. They found that PTK6 was activating a protein responsible for turning genes on and off called STAT3. Previous studies have established a role for STAT3 in proliferation and found that it plays an important role in many epithelial cancers, including skin cancer and colon cancer.

PTK6 seems to be playing opposite roles in normal and cancer cells, Tyner said.

"We believe that PTK6 may play a role in initiation of cancer in the colon, but we don't yet know what role PTK6 may play in metastasis."'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Abnormal Protein May Explain Loss of Smell With Alzheimers
2. First detection of pregnancy protein in older people destined for Alzheimers disease
3. Researchers identify enzyme that regulates degradation of damaged proteins
4. Study shows soy protein reduced progression of clogged arteries in women within 5 years of menopause
5. Novel technique reveals both gene number and protein expression simultaneously
6. Study finds protein critical to breast cancer cell proliferation, migration
7. Protein discovered at LSUHSC may suppress breast cancer growth
8. X-ray protein probe leads to potential anticancer tactic
9. Proteins could help women avoid thyroid surgery
10. Alzheimers brains found to have lower levels of key protein
11. Blood Protein Might Signal Death Risk in Elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... Florida (PRWEB) May 28, 2015 Boston ... and wife Beth, both Genesis Foundation Board of Directors ... John Havlicek Celebrity Fishing Tournament June 4-7. For the ... 4-day event benefitting The Genesis Foundation for children by ... cause. , The 34th John Havlicek Celebrity Fishing ...
(Date:5/28/2015)... May 28, 2015 " Trends Investing ” ... Report, which takes a look at small, medium, and large ... host of NewsWatch and business expert, conducted the business review ... users to where they should invest their money. , The ... concept. But doing it and knowing how to succeed ...
(Date:5/28/2015)... Workers’ compensation costs per claim in Michigan ... study by the Workers Compensation Research Institute (WCRI) ... , The WCRI study, CompScope™ Benchmarks for Michigan, 15th ... days or more of work with those of 16 other ... claim was 4 percent lower than similar claims from 2008. ...
(Date:5/28/2015)... Nidra Herbal Sleep Supplement features a 100% Ayurveda herbal ... supplement, Nidra Herbal Sleep Supplement is more than just a ... with a real sense of wellbeing the next day. ... as the “Science or Knowledge of Life”, was first used ... holistic system of knowledge which combines contemplation, herbal supplements and ...
(Date:5/28/2015)... Ticket Down is a reputable source of presale tickets ... Argentina in early September. , Two of the best ... pitch at AT&T Stadium in Arlington/Dallas, TX. Mexico and Argentina ... Tuesday, September 8th at 9 p.m. The match will feature ... some of the most loved players in the entire sport. ...
Breaking Medicine News(10 mins):Health News:The Genesis Foundation Prepares for Their Final Annual John Havlicek Celebrity Fishing Tournament 2Health News:An Application to Learn Where to Invest Money was Featured on NewsWatch Television 2Health News:Michigan Workers’ Compensation Costs Lower Than Most States, Says WCRI Study 2Health News:Ayurveda Herba Corp’s Revolutionary Herbal Sleep Supplement is Now Available from Amazon.com 2Health News:Mexico vs. Argentina Tickets at AT&T Stadium: Ticket Down Slashes Ticket Prices on Argentina vs. Mexico Presale Tickets at AT&T Stadium for 9/8/15 Friendly Match 2Health News:Mexico vs. Argentina Tickets at AT&T Stadium: Ticket Down Slashes Ticket Prices on Argentina vs. Mexico Presale Tickets at AT&T Stadium for 9/8/15 Friendly Match 3
... office visits with a diagnosis of bipolar disorder substantially ... a bipolar disorder diagnoses appeared to almost double, according ... of General Psychiatry, one of the JAMA/Archives journals. , ... periods of mania (an abnormally elevated mood) and depression. ...
... "Psoriasis Cure,Now," a nonprofit patient advocacy group, today released ... their kids head back to,school. The organization offers a ... off the internet and deliver to their child,s school,teacher; ... leading pediatric,dermatologist discussing how to treat psoriasis in children ...
... September 3 KFH has announced that it,has ... 13485 and ISO,9001:2000 quality management systems with the ... Sally Sennitt, MD, says: "We are delighted,to have ... working with BSI. It is a major milestone ...
... WASHINGTON, Sept. 2 New data about the ... news for thousands of,patients with cardiovascular disease, according ... These new findings,also underscore the crucial importance of ... implantation technique, and in prescribing a,strict regimen of ...
... -- Chinas efforts to control population growth in the ... in the future. , This prediction comes from a ... a year in China studying its geriatric policies and ... of internal medicine in the division of geriatric medicine ...
... Sept. 2 Oil Refineries Ltd. (TASE: ORL),(the "Company" ... has received a claim (the "Claim"), filed with the ... IDF units, against the Company,and nine other defendants. The ... plaintiffs allege they contracted due to their being in,the ...
Cached Medicine News:Health News:Study documents rapid increase in youth bipolar disorder diagnoses 2Health News:Psoriasis Cure Now offers 'Back to School' Resources for Parents of Children with Psoriasis 2Health News:Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up 2Health News:Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up 3Health News:China's 1-child policy could backfire on its elderly 2Health News:China's 1-child policy could backfire on its elderly 3Health News:Claim Filed Against the Company and Nine Other Defendants in the Haifa Magistrates Court 2
(Date:5/28/2015)... , May 28, 2015 Zimmer Holdings, ... it has finalized agreements with buyers to divest in ... Unicompartmental High-Flex Knee System assets, Biomet Discovery® Elbow System ... are in furtherance of Zimmer,s pending acquisition of Biomet, ... Zimmer continues to work constructively with the Bureau of ...
(Date:5/28/2015)... -- Maetrics ( http://maetrics.com ), a leading international consulting firm ... successful conference, "The cost of non-compliance -- How new regulation ... Zurich . Hosted by ... Switzerland -based team, experts provided insights on the ... an exclusive local audience. The event was held in ...
(Date:5/28/2015)... , May 28, 2015 The controversy ... )  in hysterectomies and myomectomies (procedures to remove uterine ... the FBI is investigating Johnson & Johnson,s Ethicon, ... of the devices. According to the report published ... th , the FBI is trying to determine ...
Breaking Medicine Technology:Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 2Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 3Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 4Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 5Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 6Maetrics Hosts Innovative Medical Cluster Event in Switzerland 2Power Morcellator Attorneys at Bernstein Liebhard LLP Comment on Report That FBI Is Investigating Ethicon Morcellators 2Power Morcellator Attorneys at Bernstein Liebhard LLP Comment on Report That FBI Is Investigating Ethicon Morcellators 3
... Inc., a private clinical-stage biotherapeutics company focused on the ... for cancer, today announced that the first patient has ... JX-594 as a neoadjuvant therapy in patients who are ... to the liver. The study is ...
... 21, 2011  Adeona Pharmaceuticals, Inc. (NYSE Amex: ... of Directors has taken several actions to prioritize the ... field of synthetic biology. As previously announced on November ... into a worldwide exclusive channel collaboration for the development ...
Cached Medicine Technology:Jennerex Announces First Patient Treated in Phase 2a Clinical Trial of JX-594 as a Neoadjuvant Therapy in Colorectal Cancer Patients Undergoing Surgery 2Jennerex Announces First Patient Treated in Phase 2a Clinical Trial of JX-594 as a Neoadjuvant Therapy in Colorectal Cancer Patients Undergoing Surgery 3Jennerex Announces First Patient Treated in Phase 2a Clinical Trial of JX-594 as a Neoadjuvant Therapy in Colorectal Cancer Patients Undergoing Surgery 4Jennerex Announces First Patient Treated in Phase 2a Clinical Trial of JX-594 as a Neoadjuvant Therapy in Colorectal Cancer Patients Undergoing Surgery 5Adeona Announces Proposed Name Change to Synthetic Biologics, Inc., and Appointment of John Monahan, Ph.D., as Senior Vice President of Research & Development 2Adeona Announces Proposed Name Change to Synthetic Biologics, Inc., and Appointment of John Monahan, Ph.D., as Senior Vice President of Research & Development 3Adeona Announces Proposed Name Change to Synthetic Biologics, Inc., and Appointment of John Monahan, Ph.D., as Senior Vice President of Research & Development 4
... has been selling replacement bulbs ... and we are extremely proud ... Check out our catalog of ... discount light bulbs specials. ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
Medicine Products: