Navigation Links
Knee Arthritis May Speed Up Process Linked to Cell Aging
Date:1/17/2012

TUESDAY, Jan. 17 (HealthDay News) -- A process linked to natural cell aging has now also been associated with knee osteoarthritis, researchers say.

Telomeres -- lengths of DNA on the ends of chromosomes, sometimes described as being like the plastic cap on a shoelace tip -- naturally shorten with age, but can also shorten due to sudden cell damage. Abnormally short telomeres have been found in some types of cancer and preliminary research has suggested that the average telomere length is also shortened in osteoarthritis.

In this new study, Danish researchers used new technology to closely examine the telomeres of cells taken from the knees of osteoarthritis patients who had joint replacement surgery.

The cells had abnormally shorted telomeres and the percentage of cells with ultra-short telomeres increased with proximity to the damaged area in the knee joint, according to the findings published in the Jan. 16 online edition of the journal Arthritis Research & Therapy.

"The telomere story shows us that there are, in theory, two processes going on in osteoarthritis. Age-related shortening of telomeres, which leads to the inability of cells to continue dividing and so to cell senescence [deterioration], and ultra-short telomeres, probably caused by compression stress during use, which lead to senescence and failure of the joint to repair itself," study leader Maria Harbo said in a journal news release.

"We believe the second situation to be the most important in osteoarthritis. The damaged cartilage could add to the mechanical stress within the joint and so cause a feedback cycle driving the progression of the disease," she added.

More information

The University of Utah has more about telomeres.

-- Robert Preidt

SOURCE: Arthritis Research & Therapy, news release, Jan. 16, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ultra short telomeres linked to osteoarthritis
2. Herbal Medicines for Arthritis Not Backed by Evidence
3. Diet Might Help Those Immobilized by Knee Osteoarthritis
4. Mindfulness Training May Help Arthritis Patients Cope
5. Salk discovery may lead to safer treatments for asthma, allergies and arthritis
6. More Americans Exercise, but Arthritis Can Get in the Way
7. Early Ovary Removal May Raise Arthritis, Osteoporosis Risk
8. Osteoarthritis results from inflammatory processes, not just wear and tear, Stanford study suggests
9. Knee Arthritis Striking at Younger Ages, But Weight Loss May Help
10. Study identifies factors linked with better medication response for treatment of juvenile arthritis
11. Rheumatoid arthritis patients have low expectations after knee replacement surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Knee Arthritis May Speed Up Process Linked to Cell Aging
(Date:6/27/2016)... Overland Park, KS (PRWEB) , ... June 27, 2016 , ... ... leader in retailers of Eyeglasses . , Millions of individuals in the United ... life, eyeglasses have become a way to both correct vision and make a fashion ...
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
Breaking Medicine Technology: