Navigation Links
Knee Arthritis May Speed Up Process Linked to Cell Aging
Date:1/17/2012

TUESDAY, Jan. 17 (HealthDay News) -- A process linked to natural cell aging has now also been associated with knee osteoarthritis, researchers say.

Telomeres -- lengths of DNA on the ends of chromosomes, sometimes described as being like the plastic cap on a shoelace tip -- naturally shorten with age, but can also shorten due to sudden cell damage. Abnormally short telomeres have been found in some types of cancer and preliminary research has suggested that the average telomere length is also shortened in osteoarthritis.

In this new study, Danish researchers used new technology to closely examine the telomeres of cells taken from the knees of osteoarthritis patients who had joint replacement surgery.

The cells had abnormally shorted telomeres and the percentage of cells with ultra-short telomeres increased with proximity to the damaged area in the knee joint, according to the findings published in the Jan. 16 online edition of the journal Arthritis Research & Therapy.

"The telomere story shows us that there are, in theory, two processes going on in osteoarthritis. Age-related shortening of telomeres, which leads to the inability of cells to continue dividing and so to cell senescence [deterioration], and ultra-short telomeres, probably caused by compression stress during use, which lead to senescence and failure of the joint to repair itself," study leader Maria Harbo said in a journal news release.

"We believe the second situation to be the most important in osteoarthritis. The damaged cartilage could add to the mechanical stress within the joint and so cause a feedback cycle driving the progression of the disease," she added.

More information

The University of Utah has more about telomeres.

-- Robert Preidt

SOURCE: Arthritis Research & Therapy, news release, Jan. 16, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ultra short telomeres linked to osteoarthritis
2. Herbal Medicines for Arthritis Not Backed by Evidence
3. Diet Might Help Those Immobilized by Knee Osteoarthritis
4. Mindfulness Training May Help Arthritis Patients Cope
5. Salk discovery may lead to safer treatments for asthma, allergies and arthritis
6. More Americans Exercise, but Arthritis Can Get in the Way
7. Early Ovary Removal May Raise Arthritis, Osteoporosis Risk
8. Osteoarthritis results from inflammatory processes, not just wear and tear, Stanford study suggests
9. Knee Arthritis Striking at Younger Ages, But Weight Loss May Help
10. Study identifies factors linked with better medication response for treatment of juvenile arthritis
11. Rheumatoid arthritis patients have low expectations after knee replacement surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Knee Arthritis May Speed Up Process Linked to Cell Aging
(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance ... greater Dallas, Miami, and Raleigh regions, is organizing an extended charity drive to ... and deadly chromosome abnormality. , After struggling since birth with several health challenges, ...
(Date:10/13/2017)... ... 2017 , ... As health professionals work to improve their approach to healthcare, ... doing more than filling out a survey; in many cases health professionals and patients ... health care and research on the importance of active engagement with patients and members ...
(Date:10/13/2017)... LEXINGTON, Ky. (PRWEB) , ... October 13, 2017 , ... ... MD, MPH to become its next President and Chief Executive Officer, succeeding Dr. James ... and CEO Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and ... Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD ... that can be easily incorporated into liquid products, while reducing costs to end users. ...
(Date:10/13/2017)... ... 2017 , ... Lori R. Somekh, founder of the Law Office of ... elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain ... to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... MENLO PARK, Calif. , Oct. 11, 2017 /PRNewswire/ ... a national scientific team that developed an innovative way ... and quantity of the delivery of new drugs. ... the 2017 Fall Clinical Dermatology Conference will show how ... Massachusetts General Hospital, Harvard Medical School used a suite ...
(Date:10/10/2017)... 2017  NDS received FDA 510(k) clearance in May 2017 for ... stand specifically designed for endoscopy environments. An innovative secondary monitor solution, ... solution to support the improvement of patient outcomes, procedural efficiency, and ... ... ...
(Date:10/4/2017)... Korea , Oct. 4, 2017  South Korean-based ... next-generation CPR training aide "cprCUBE" on Kickstarter. The device ... compression during cardiac arrests with better efficiency compared to ... also offers real-time feedback on efficacy of the compression ... crowdfunding campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: