Navigation Links
Knee Arthritis May Speed Up Process Linked to Cell Aging
Date:1/17/2012

TUESDAY, Jan. 17 (HealthDay News) -- A process linked to natural cell aging has now also been associated with knee osteoarthritis, researchers say.

Telomeres -- lengths of DNA on the ends of chromosomes, sometimes described as being like the plastic cap on a shoelace tip -- naturally shorten with age, but can also shorten due to sudden cell damage. Abnormally short telomeres have been found in some types of cancer and preliminary research has suggested that the average telomere length is also shortened in osteoarthritis.

In this new study, Danish researchers used new technology to closely examine the telomeres of cells taken from the knees of osteoarthritis patients who had joint replacement surgery.

The cells had abnormally shorted telomeres and the percentage of cells with ultra-short telomeres increased with proximity to the damaged area in the knee joint, according to the findings published in the Jan. 16 online edition of the journal Arthritis Research & Therapy.

"The telomere story shows us that there are, in theory, two processes going on in osteoarthritis. Age-related shortening of telomeres, which leads to the inability of cells to continue dividing and so to cell senescence [deterioration], and ultra-short telomeres, probably caused by compression stress during use, which lead to senescence and failure of the joint to repair itself," study leader Maria Harbo said in a journal news release.

"We believe the second situation to be the most important in osteoarthritis. The damaged cartilage could add to the mechanical stress within the joint and so cause a feedback cycle driving the progression of the disease," she added.

More information

The University of Utah has more about telomeres.

-- Robert Preidt

SOURCE: Arthritis Research & Therapy, news release, Jan. 16, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ultra short telomeres linked to osteoarthritis
2. Herbal Medicines for Arthritis Not Backed by Evidence
3. Diet Might Help Those Immobilized by Knee Osteoarthritis
4. Mindfulness Training May Help Arthritis Patients Cope
5. Salk discovery may lead to safer treatments for asthma, allergies and arthritis
6. More Americans Exercise, but Arthritis Can Get in the Way
7. Early Ovary Removal May Raise Arthritis, Osteoporosis Risk
8. Osteoarthritis results from inflammatory processes, not just wear and tear, Stanford study suggests
9. Knee Arthritis Striking at Younger Ages, But Weight Loss May Help
10. Study identifies factors linked with better medication response for treatment of juvenile arthritis
11. Rheumatoid arthritis patients have low expectations after knee replacement surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Knee Arthritis May Speed Up Process Linked to Cell Aging
(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults ... tested to meet the highest standard. , These products are also: Gluten ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... has recently contributed a medical article to the newly revamped Cosmetic Town ... article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
(Date:10/12/2017)... ... 2017 , ... Health Literacy Innovations (HLI), creator of the ... the Cancer Patient Education Network (CPEN), an independent professional organization that shares best ... alliance. , As CPEN’s strategic partner, HLI will help support CPEN members ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... the Centers for Disease Control and Prevention (CDC), influenza vaccination should ... helping communities across Massachusetts , Connecticut ... shots through the end of the month. *Some exclusions apply ... ... is by the end of October, according to the Centers for Disease ...
(Date:10/2/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ... LLC , and named its founder as Diplomat,s chief ... Tennessee , will operate under Diplomat subsidiary ... offerings for health care partners to include IT outsourcing, ... "In an interoperable world, technology delivers comprehensive insight ...
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
Breaking Medicine Technology: