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Kite Pharma announces positive results in patients with aggressive non-Hodgkin's lymphoma
Date:8/25/2014

nses ranged from 9 to 22 months in patients with chemotherapy-refractory DLBCL and from 11 to 23 months in the patients with either chronic lymphocytic leukemia (CLL) or indolent lymphoma. Pursuant to the study protocol, patients are continuing to be monitored for duration of response. Updated results will be reported at the appropriate peer-reviewed forum.

Summary of Efficacy Findings:

Disease (Evaluable Patients) Complete Remission (CR) Partial Remission
7 Chemotherapy-refractory DLBCL(1) 4 Patients (3 patients with duration of ongoing CR from 9 to 22 months) 2 Patients
4 CLL 3 Patients (duration of ongoing CR from 14 to 23 months) 1 Patient
2 Indolent Lymphomas 1 Patient (duration of ongoing CR 11 months) 1 Patient

(1) Includes one patient with DLBCL that transformed from chronic lymphocytic leukemia, and three patients with primary mediastinal B cell lymphoma, a subtype of DLBCL.

As seen in other studies, infusion of anti-CD19 CAR T cells was associated with significant, acute toxicities, including fever, low blood pressure, focal neurological deficits, and delirium.


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Contact: Justin Jackson
jjackson@burnsmc.com
212-213-0006 x327
Burns McClellan
Source:Eurekalert

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