Navigation Links
Kinesin-5 structure opens cancer drug targets
Date:4/8/2014

The structure of a key part of the machinery that allows cells to divide has been identified by researchers at the University of California, Davis -- opening new possibilities for throwing a wrench in the machine and blocking runaway cell division in cancer.

"The structure of kinesin-5 is unexpected, and the implications are big -- it allows us to target it, for example in various forms of cancer," said Jawdat Al-Bassam, assistant professor of molecular and cellular biology at UC Davis, who led the project.

"This fills in a major missing piece, because for the first time we can understand how microtubule filaments can be linked together and slide past each other," he said.

The work will be published in the online journal eLife and is available at (elife website DOI)When a cell divides into two new cells, a structure called the mitotic spindle forms. Microtubules of protein fan out from each end of the cell, capture chromosomes and draw them apart into what will become the two new cells. Precise coordination of this process is crucial for cells to divide properly, and for avoiding birth and developmental defects.

Cancer cells divide continuously, so this process repeats itself much more often in cancer cells than in normal cells.

The kinesins are a large family of motor proteins that move items around inside cells, said Jonathan Scholey, professor of molecular and cellular biology at UC Davis and an author on the paper. Generally, they have two motor units at one end that can "walk" along a microtubule, dragging cargo attached to the other end of the protein.

Originally identified as a protein essential for mitosis in fungi, kinesin-5 was first purified about 20 years ago by Scholey's lab who found that it is unusual because it has motor units at both ends, allowing it to link two microtubules and walk them past each other.

"It's now understood to be absolutely essential for mitosis in
'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Males and females differ in specific brain structures
2. DNA-built nanostructures safely target, image cancer tumors
3. Brain structure shows who is most sensitive to pain
4. Bacterial Skin and Skin Structure Infections Market: SSSI Pipeline Review, H2 2013 at ReportsnReports.com
5. Polymer coatings based on molecular structures
6. NIH names leadership, research units for restructured HIV/AIDS
7. Heavy marijuana users have abnormal brain structure and poor memory
8. Skin And Skin Structure Infections (SSSI) Caused By Bacteria 2013
9. ZyDoc Links Philips SpeechExec Enterprise to MediSapien Structured Reporting and Analytics for Radiology at RSNA 2013
10. Middle East Critical Infrastructure Protection (CIP) Market (Technology, Solutions, Services) Worth $13.07 Billion by 2018 - New Report by MarketsandMarkets
11. Unique change in protein structure guides production of RNA from DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Hawley, PA (PRWEB) January 22, 2015 Woodloch ... Pocono Mountains, has been selected by TripAdvisor as the number ... and the 6th best in the world for their annual ... online travel community . The website is home to ...
(Date:1/22/2015)... is a famous wedding dress company offering many trendy designs. ... Facebook, Twitter, and Pinterest. The fans will have an opportunity ... every week. , Moreover, the company has extended its 2015 ... homepage for more information. , Angelweddingdress is a ...
(Date:1/22/2015)... Dallas, TX (PRWEB) January 22, 2015 ... the issue of experience and person-centeredness in the long-term ... moving towards action across the continuum. The paper, “The ... the Continuum,” engages perspectives and practices of the patient, ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved television host, ... 32nd Annual Miami Breast Cancer Conference planned and ... , shares that “a fast-growing, virulent” cancer in her ... not followed up her clean mammogram with an ultrasound. ...
(Date:1/22/2015)... Four years since the release of their debut ... the marriage of Avasa & Matthew Love – the duo are ... for release through White Swan Records on February 24, 2015. , ... sacred path available to all of us to walk out of ...
Breaking Medicine News(10 mins):Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... ... distribution underway, PORTLAND, Maine, Dec. 4 Maine,s Good ... simmer sauces for,chicken. The new sauces -- Cacciatore, French Tarragon and ... north Atlantic (MA,ME, RI) and northeast regions (NY, NJ, CT), with ...
... Tubbs Jones released this statement commemorating the 19th,Anniversary of ... was World AIDS Day, a day where we pause,to ... that has proved to,be so devastating to so many ... 65 million people have been infected with,the HIV virus, ...
... 4 /PRNewswire-FirstCall/ - Nventa,Biopharmaceuticals Corporation (TSX:NVN) announced today ... Directors effective as of today to,pursue other interests., ... Board of Directors, commented,on the Board change: "As ... at,Queen,s University, Margot,s knowledge, combined with her experience ...
... Symbol: DND, MISSISSAUGA, ON, Dec. 4 /PRNewswire-FirstCall/ ... it has appealed the position taken by,the U.S. ... letter for,CIP-TRAMADOL ER, using the FDA,s Formal Dispute ... FDA in May 2007 pertaining to its,New Drug ...
... Local ... Pediatrician,s Office, HOUSTON, Dec. 4 AMERIGROUP ... pediatrician Dr.,Muhammad Shaikh at the Bissonet Medical Center in Houston. The ... Community,Care sponsored for the area,s physicians and its providers., Dr. ...
... Aida,Pharmaceuticals (OTC Bulletin Board: AIDA) today ... has been named as a "New and,High-Tech ... New High,Technology Service Centre ("SNHTSC"), a special ... Government. This,designation will allow Rh-Apo2L to have ...
Cached Medicine News:Health News:Good Clean Food's New Line of All-Natural Simmer Sauces for Chicken Hits Market Shelves 2Health News:Good Clean Food's New Line of All-Natural Simmer Sauces for Chicken Hits Market Shelves 3Health News:Tubbs Jones Commemorates World AIDS Day 2Health News:Cipher Appeals FDA's Decision On CIP-TRAMADOL ER 2Health News:AMERIGROUP Community Care Provides 'Doctor's Office Makeover' in Houston 2Health News:Rh-Apo2L Named as One of China's High-Tech Transforming Products by Chinese Government 2
(Date:1/23/2015)... Markets ( http://www.researchandmarkets.com/research/vzhr6h/video ) has announced the addition ... Share, Growth, Trends and Forecast 2014 - 2020" report ... topic of fascination since the era of the cold war ... Soviet Russia. Earlier even a small glimpse of human form ...
(Date:1/23/2015)... Partnership to Fight Chronic Disease (PFCD) released a public opinion poll ... new study analyzing the impact of increased cost sharing on patient ... to educate policy makers and the public on the costs of ... how the Iowa healthcare exchange could be ...
(Date:1/23/2015)... 23, 2015  MedScope ( www.medscope.org ), the leading provider ... 2015 Connected World magazine Connected World Award ... that can be used anywhere, anytime. The nomination was ... In nominating MedScope, Landon Garner , Director ...
Breaking Medicine Technology:Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2
... , NEW YORK , ... management company, has been granted a license by the Virginia ... the State of Virginia as a Private Review ... management of radiology procedures for commercial, Medicare, and Medicaid products ...
... , GLENWOOD, Ill. , Jan. 25 ... financial results for the fiscal first quarter of 2010 pre-market on ... conference call for investors on Tuesday, February 2, 2010 , at ... by dialing 877-941-8631 (within the United States and Canada ...
Cached Medicine Technology:Care to Care Licensed to Manage High-cost Radiology in Virginia 2Care to Care Licensed to Manage High-cost Radiology in Virginia 3Landauer, Inc. Sets Date and Time for Announcement of Fiscal First Quarter 2010 Results 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: