Navigation Links
Kinase test may yield big gains for drug-resistant cancers
Date:4/12/2012

Chapel Hill, NC In a paper published today in the journal Cell, a team from the University of North Carolina at Chapel Hill unveils the first broad-based test for activation of protein kinases "en masse", enabling measurement of the mechanism behind drug-resistant cancer and rational prediction of successful combination therapies.

Kinases are proteins expressed in human tissues that play a key role in cell growth, particularly in cancer. Of the 518 known human kinases, about 400 are expressed in cancers, but which ones and how many are actually active in tumors has been difficult to measure. Tremendous efforts have been made to develop kinase inhibitors as cancer treatments, which have resulted in key drugs such as Herceptin, Tykerb, and Gleevec. However, in spite of the effectiveness of this class of cancer drugs, most cancers eventually become resistant. The UNC team has developed a test that can measure both the presence and activity of 60-70 percent of all kinases simultaneously, allowing investigators to see how cancers evade treatment with kinase inhibitors so that they can combine drugs to block resistance.

Gary Johnson, PhD, the project's principal investigator, says, "Single-agent kinase inhibitors are promising in principle, but often fail in practice because the network of tumor kinases learns how to get around the inhibitor, leading to rapid drug resistance. We're very excited about the test our lab has developed because it works very well in a model of breast cancer to predict the success of combination therapies."

Johnson, who is the Kenan Distinguished Professor and chair of the department of pharmacology in the UNC School of Medicine and a member of UNC Lineberger Comprehensive Cancer Center, is working with UNC Breast Center medical director Lisa Carey, MD, UNC Lineberger director Shelley Earp, MD, and surgical oncologist Keith Amos, MD, to perform clinical tr
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Battlefield camaraderie yields long-term dividends for veterans, study finds
2. Why do physicians order costly CTs? Ultrasound yields better diagnosis, safer, less costly
3. Gene Sequencing Yields Picture of Human Gut
4. HealthSouth To Present at Barclays Capital 2010 High Yield Bond and Syndicated Loan Conference
5. Abbreviated Trials Yield Misleading Results: Study
6. H1N1 Virus Yields Up More Secrets
7. Safety and diagnosis yield of colonoscopy in Hong Kong Chinese children
8. Glued graft for Pterygium Yield Better Cosmetic Results
9. Pigs Yield Clues to Cystic Fibrosis-Related Lung Disease
10. Phase II study of an oral therapy for Gaucher disease yields positive results
11. In infant heart surgery, newer technique yields better survival in first year of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Healthcare professionals will be able to access ... available at the point of care following an agreement ... Comprehensive Cancer Network® (NCCN®). Information from NCCN will ... the content available from the clinical reference tool ... of 25 of the world's leading cancer centers devoted ...
(Date:9/2/2014)... from cancer surgery may be influenced by more ... Family conflicts and other non-medical problems may raise ... study has found. Addressing such quality-of-life issues before ... recoveries and save health care dollars, the research ... patients, and found that patients with a poor ...
(Date:9/2/2014)... the key to more youthful immune function might already ... in the Journal of Leukocyte Biology ... old mice had different responses to Mycobacterium tuberculosis ... were reversed by ibuprofen. , "Inflammation in old age ... Turner, Ph.D., a researcher involved in the work from ...
(Date:9/2/2014)... According to a new report by ... authority in medical device market research, the ... grow to over €2 billion in 2020. Growth ... number of procedures for the treatment of BPH, ... TURP devices, laser BPH devices, brachytherapy, urinary catheters, ...
(Date:9/2/2014)... New York (PRWEB) September 02, 2014 ... application of nanotechnology in diagnosing, treating and/or prevention ... are applied for treating cardiovascular, neurological, and oncology ... utilization of knowledge pertaining to various nanoparticles, their ... body., There still exists considerable scope for research ...
Breaking Medicine News(10 mins):Health News:DynaMed™ to Utilize Information from the National Comprehensive Cancer Network® 2Health News:DynaMed™ to Utilize Information from the National Comprehensive Cancer Network® 3Health News:DynaMed™ to Utilize Information from the National Comprehensive Cancer Network® 4Health News:Family conflicts, other non-physical worries before cancer surgery raise patients' complication risk 2Health News:European Urological Device Market Is Expected to Grow to over €2 billion by 2020: Led by Coloplast, Wellspect HealthCare, Teleflex, C. R. Bard and Olympus 2Health News:European Urological Device Market Is Expected to Grow to over €2 billion by 2020: Led by Coloplast, Wellspect HealthCare, Teleflex, C. R. Bard and Olympus 3Health News:Nanomedicine Market: An Overview of Growth Factors and Future Prospects by Transparency Market Research 2Health News:Nanomedicine Market: An Overview of Growth Factors and Future Prospects by Transparency Market Research 3
... /Xinhua-PRNewswire-FirstCall/ -- Mindray,Medical International Limited (NYSE: MR ... devices worldwide, today announced the company and,its employees ... million,through the Red Cross Society of China to ... Mr. Xu Hang and Mr. Li Xiting,Mindray,s co-chief ...
... alternative,medicine is a diverse group of health care ... traditional medicine. According to the U.S.,Department of Health ... and alternative medicine, which includes dietary supplements., ... of dietary supplements has grown considerably in the ...
... Hopkins undergraduates have designed and built a device to ... their beds and walk while remaining tethered to essential ... whether carefully supervised rehabilitation, as opposed to continuous sedation ... care patients. , Some clinicians believe that allowing ICU ...
... LONDON, May 29 More northern women feel bloating ... of them likely to,experience it at any one time, ... from the West Midlands and Yorkshire and Humberside fared ... experiencing the least,amount of bloated feelings. And 61% of ...
... youth smoking uptake greatly reduced if parents quit, LONDON, ... research shows that a child,s odds of daily smoking are,reduced ... continue,to smoke. And if both parents were smokers but quit, ... shows that mothers who,quit are less likely to have children ...
... The following is a,statement of Matthew L. Myers, ... Sheila Dixon and Baltimore City Health Department,Commissioner Dr. ... protect,the city,s children and health by proposing a ... The proliferation of individually sold cigars in ...
Cached Medicine News:Health News:Mindray Donates Cash and Equipment for Sichuan Earthquake Relief 2Health News:Figure Skater Peggy Fleming Teams With HealthSaver: The Impact of Diet and Supplements on Health 2Health News:Figure Skater Peggy Fleming Teams With HealthSaver: The Impact of Diet and Supplements on Health 3Health News:Figure Skater Peggy Fleming Teams With HealthSaver: The Impact of Diet and Supplements on Health 4Health News:Figure Skater Peggy Fleming Teams With HealthSaver: The Impact of Diet and Supplements on Health 5Health News:Figure Skater Peggy Fleming Teams With HealthSaver: The Impact of Diet and Supplements on Health 6Health News:Students' device allows ICU patients to get back on their feet 2Health News:Students' device allows ICU patients to get back on their feet 3Health News:North South Divide Exists in UK Digestive Health 2Health News:North South Divide Exists in UK Digestive Health 3Health News:Parents: Quit Smoking and Your Children Are Less Likely to Smoke 2Health News:Parents: Quit Smoking and Your Children Are Less Likely to Smoke 3Health News:Parents: Quit Smoking and Your Children Are Less Likely to Smoke 4Health News:Baltimore's Proposed Ban on Sale of Single, Cheap Cigars Would Protect Kids and Health 2
(Date:9/2/2014)... Sept. 2, 2014  Abaxis, Inc. (NasdaqGS: ... instrumentation and consumables to the medical, research and veterinary ... and Chief Executive Officer, will present at the Morgan ... at 10:20 a.m. ET. The conference will be held ... New York City . About Abaxis ...
(Date:9/2/2014)...  Hologic, Inc. (NASDAQ: HOLX ) today announced ... will present at the Morgan Stanley Global Healthcare Conference in ... York on Tuesday, September 9, 2014 at 12:20 ... listen to the live audio webcast of the presentation on ... An archive of the presentation will be available for replay ...
(Date:9/2/2014)... SAN DIEGO , Sept. 2, 2014  Arena ... that the US Food and Drug Administration (FDA) has ... of pulmonary arterial hypertension. "The FDA ... clinical data submissions from sponsors to identify and designate ... help advance the evaluation and development of such products," ...
Breaking Medicine Technology:Abaxis, Inc. to Present at the Morgan Stanley Global Healthcare Conference 2Arena Pharmaceuticals' APD811 Granted Orphan Drug Status for Pulmonary Arterial Hypertension 2Arena Pharmaceuticals' APD811 Granted Orphan Drug Status for Pulmonary Arterial Hypertension 3Arena Pharmaceuticals' APD811 Granted Orphan Drug Status for Pulmonary Arterial Hypertension 4
... ARLINGTON HEIGHTS, Ill., Sept. 12 Even as,many ... available today,we are stopped by our rear reflection and ... study published in the October issue of Plastic and,Reconstructive ... Plastic Surgeons (ASPS), reveals a new back lift procedure ...
... Ala., Sept. 11 - Southern,Research Institute and ... from a study testing Naltrexone-derived,pyridomorphinan (SoRI-9409) will ... of,the journal Biological Psychiatry. The publication is ... suggests that a new compound that,causes selective ...
Cached Medicine Technology:Say 'Goodbye' to Back Fat Rolls 2Novel Compound Shows Promise for Treatment of Alcoholism 2Novel Compound Shows Promise for Treatment of Alcoholism 3Novel Compound Shows Promise for Treatment of Alcoholism 4
The Tag-It™ Cystic Fibrosis ASR reagents can be used by high complexity CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis tran...
The Ultra HDL (UHDL) assay is used for the quantitation of high density lipoprotein (HDL) cholesterol in human serum or plasma....
... A histological embedment block ... This file system incorporates ... embedment block protection, simplified ... error and facilitation of ...
... The first instrumentation ... efficiently manage the ... Proven technology automatically ... collates cassettes sequentially. ...
Medicine Products: