Navigation Links
Killer competition: Neurons duke it out for survival
Date:5/6/2008

e to simulate a cells drive to survive. When they plugged in the model, it showed that over time-about 100 days or so-about half of the cells manage to survive, while the other half die.

But, in the developing mouse embryo, nerve cells that die do so over the course of two to three days just before birth. So then we considered whether these nerves compete like other systems in the body, where those with stronger connections punish the weaker ones, says Ginty. The team turned their attention to other genes they found to be NGF dependent; two of which code for proteins that kill neighboring nerve cells and another is the receptor for these death proteins.

According to Ginty, nerves that connect to muscles undergo a similar process called synapse elimination where stronger connections stay connected and weaker ones are eliminated. The team wondered if this is also true of peripheral nerve cells competing for NGF availability and ultimate cell survival. To test this idea they plugged these three additional genes into their computer model, assuming that the stronger connected nerve cell punishes its neighbors by releasing the two proteins capable of killing. The computer model showed again, that half the nerve cells die over time, but this time the death occurred over two to three days rather than 100 days, just as in living animals.

To confirm that the model is accurate, the team went back to genetically altered mice. They predicted that removal of the punishment signals should delay cell death as observed in their early computer simulations. Indeed, nerve cells in mice lacking the receptor protein for the death signals died much slower than in mice with the receptor protein intact.

I never would have believed that these three genes could speed up competition so much, says Ginty. But there it was in front of us-it was amazing.


'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Hundreds of Heart Disease and Stroke Survivors Urge Congress to Step Up the Fight Against the Nations No. 1 Killer
2. Study shows doctors offices can help stem abuse of Oxycontin, other narcotic painkillers
3. User Registry May Help Docs Stem Painkiller Abuse
4. Painkillers Boost Muscle Mass Among Weight-Training Elderly
5. Are blood thinners post-op killers?
6. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
7. Stopping a deadly killer
8. Killer stairs? Taking the elevator could be worse for your body
9. GFX: Wrinkle-Killer or Botox(R) Hit-Man?
10. New Mini-Documentary Exposes Psychiatric Drugs Turning Kids into Killers
11. Severe hypertension: Silent killer still on the loose
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 ... after Fresenius Medical Care recalled its GranuFlo and NaturaLyte ... multidistrict litigation underway in U.S. District Court, District of ... dated January 20th, the Court has remanded a case ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved ... upcoming 32nd Annual Miami Breast Cancer Conference ... LLC (PER®) , shares that “a fast-growing, virulent” cancer ... she had not followed up her clean mammogram with ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative ... design to treat specific body parts and muscle groups. , ... easy to use patented cold therapy machine with the innovative ... and muscle injuries. IsoComforter has become the industry leader ...
(Date:1/22/2015)... 22, 2015 As interest in the value ... gains momentum worldwide, Rev. Eric J. Hall , president ... (HCCN), will be the keynote speaker on January 27 ... public health system. , The conference, “Hope and Resilience: Innovative ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Step into ... at the Science Museum of Virginia. Wicked Plants, the ... Wicked Plants unearths 75 poisonous, carnivorous and diabolical plants ... each room to uncover the biochemical, physical and neurological ...
Breaking Medicine News(10 mins):Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Wicked Plants are taking over the Science Museum of Virginia 2
... Intensive Care Unit (NSU) has earned the prestigious Beacon ... honor from the American Association of Critical Care Nurses ... four other intensive care units at University Hospitals Case ... Awards: Medical Intensive Care Unit (MICU); Cardiac Intensive ...
... HealthDay Reporter , SUNDAY, Oct. 3 (HealthDay News) -- ... or black fare worse than others if they get cancer, ... racial factors that impact diagnosis, treatment and survival, were scheduled ... Association for Cancer Research in Miami. Lack of private ...
... how the body metabolises drugs save both time ... drugs come from combining such simulations with,laboratory experiments, ... "My research demonstrates the benefits of combining ... understand and explain how the body,s various enzymes ...
... Findings from the largest nationally representative study of ... Indiana University sexual health researchers, provides an updated ... behaviors, including a description of more than 40 ... sexual events, patterns of condom use by adolescents ...
... &Science University may have uncovered a new weapon for ... newborn child. The research, which was led by researchers ... published in the October 3rd online edition of the ... of HIV is a tremendous worldwide problem, especially in ...
... FRANCISCO One in eight parents reported that his ... medication, laboratory testing and/or appointments with specialists during ... and payment, according to a study, presented Sunday, Oct. ... Conference and Exhibition in San Francisco. For ...
Cached Medicine News:Health News:University Hospitals Case Medical Center's neuroscience intensive care unit earns Beacon Award 2Health News:Insurance, Race and Poverty Affect Cancer Care, Researchers Report 2Health News:Insurance, Race and Poverty Affect Cancer Care, Researchers Report 3Health News:Best drug development results from computer/test tube combination 2Health News:New study highlights sexual behavior, condom use by US individuals ages 14 to 94 2Health News:New study highlights sexual behavior, condom use by US individuals ages 14 to 94 3Health News:New study highlights sexual behavior, condom use by US individuals ages 14 to 94 4Health News:OHSU research reveals possible method for boosting the immune system to protect infants against HIV 2Health News:OHSU research reveals possible method for boosting the immune system to protect infants against HIV 3Health News:1 in 8 parents forgoes pediatrician-recommended care 2
(Date:1/22/2015)... , Jan. 22, 2015  Amgen (NASDAQ: AMGN ) ... year 2014 financial results on Tuesday, Jan. 27, 2015, after the ... by a conference call with the investment community at 2 p.m. ... A. Bradway , chairman and chief executive officer, and other members ...
(Date:1/22/2015)... Calif. , Jan. 22, 2015 Increasing sophistication ... continued consolidation of localization purchasing in 2015, says ... According to a recent study by market research firm ... a single-source solution for their translation and localization needs. ...
(Date:1/22/2015)... ( http://www.researchandmarkets.com/research/w25xpc/allergy ) has announced the addition of ... by End User - Global Forecast to 2019" report ... market is valued at $1,228.58 million in 2014 and is ... $2,230.72 million by 2019. Allergy diagnostics is used to determine ...
Breaking Medicine Technology:Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 3
... BELGRADE, Mont., Nov. 15, 2010 Bacterin International Holdings, ... BIHI ), a developer of anti-infective coatings for ... financial results for its third quarter ended September 30, ... the reverse merger transaction reported in the Company,s Form ...
... Corporation (Nasdaq: PRXL ), a leading global biopharmaceutical ... 2010 Scrip Award for "Clinical Research Team of ... at the sixth annual Scrip Awards ceremony, hosted ... information service for the global pharmaceutical industry, on November 4, ...
Cached Medicine Technology:Bacterin International Holdings, Inc. Reports Third Quarter 2010 Financial Results 2Bacterin International Holdings, Inc. Reports Third Quarter 2010 Financial Results 3Bacterin International Holdings, Inc. Reports Third Quarter 2010 Financial Results 4Bacterin International Holdings, Inc. Reports Third Quarter 2010 Financial Results 5Bacterin International Holdings, Inc. Reports Third Quarter 2010 Financial Results 6Bacterin International Holdings, Inc. Reports Third Quarter 2010 Financial Results 7Bacterin International Holdings, Inc. Reports Third Quarter 2010 Financial Results 8Bacterin International Holdings, Inc. Reports Third Quarter 2010 Financial Results 9PAREXEL Wins Clinical Research Team of the Year Scrip Award 2PAREXEL Wins Clinical Research Team of the Year Scrip Award 3PAREXEL Wins Clinical Research Team of the Year Scrip Award 4PAREXEL Wins Clinical Research Team of the Year Scrip Award 5
Mounted on a fully adjustable molded,headband with crown strap and comfort,cushions, the sturdy Trueview Classic is,lightweight, comfortable and durable....
Mounted on a fully adjustable molded,headband with crown strap and comfort,cushions, the sturdy Halogen III Classic is,lightweight, comfortable and durable....
Mounted on a sturdy, molded headband,the Classic has a fully adjustable,crown strap and cushioning that adds,to your comfort....
... InterGro DBM putty is a ... most trusted names in human tissue ... in bone grafting technology. InterGro ... lipid carrier (lecithin) to deliver a ...
Medicine Products: