Navigation Links
Kids With Down Syndrome Might Get Help Learning
Date:6/4/2010

Tests with mice suggest potential avenue for improving mental functioning, researchers say

FRIDAY, June 4 (HealthDay News) -- Researchers say they improved the learning capacity of mice afflicted with a disease similar to Down syndrome by interfering with the production of a specific protein.

The "beta-amyloid" protein is found in mice and people, the study authors noted, and is thought to play a role in the cognitive decline associated with Alzheimer's and Down syndrome.

The study, reported online June 3 in the journal PLoS One, was conducted using 4-month-old mice that had a genetic anomaly that caused them to display learning disabilities similar to those in children with Down syndrome.

This preliminary study raises the intriguing possibility that drugs that lower beta-amyloid levels might offer some benefit to children with Down syndrome, study co-author Dr. Craig Powell, an assistant professor of neurology at UT Southwestern Medical Center in Dallas, said in a news release.

The authors point out that Down syndrome is a genetic disease caused by the presence of an extra copy of chromosome 21, which leads to the above-normal production of beta-amyloid.

With that in mind, Powell and his colleagues treated young mice with the experimental drug DAPT, which blocks beta-amyloid production by targeting a key enzyme, gamma-secretase.

After four days of treatment, the mice experienced a 40 percent drop in beta-amyloid levels. In turn, maze navigation tests revealed an improvement in their ability to learn tasks, so that eventually their performance was deemed as good as that of mice with no genetic impairment.

The researchers cautioned, however, that for the time-being this particular approach is a blunt instrument that blocks not only the targeted enzyme's ability to spark beta-amyloid production but also a host of other critical tasks the enzyme performs, many of which
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Choir Singing May Relieve Irritable Bowel Syndrome
2. A Protein Links Alzheimers, Down Syndrome
3. Behavior therapy effective in reducing tics in children with Tourette syndrome, study finds
4. Restless Legs Syndrome Can Have Family Ties
5. UT Southwestern researchers uncover Fragile X syndrome genes role in shaping brain
6. Brain Develops Differently in Fragile X Syndrome
7. Getting Closer to Cause of Tourette Syndrome
8. Study of Williams syndrome patients reveals specific genes role in intelligence
9. Nutrition researchers to develop new growth charts for children with Down syndrome
10. Guillain-Barre Syndrome Very Rare After H1N1 Vaccine
11. Gulf War Syndrome Is Real, But Causes Unclear: Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... LiveOps, Inc., the global leader in cloud ... LiveOps has been selected as a call center provider ... Telethon for the third year in a row. This ... support MDA’s mission to help children and adults affected ... disease. This year’s program includes performances by Bret Michaels, ...
(Date:8/29/2014)... Thirteen Novant Health registered nurses have ... in North Carolina list by Great 100, Inc., ... to nursing students at all levels across the state. ... Medical Center are: Rea Buie, Carol Caldwell, Susan ... Amber Segerlin, Carmen Smith, Melissa Stafford and Deborah Stegall. ...
(Date:8/29/2014)... Steven Reinberg HealthDay ... -- The vast majority of American babies are getting ... illnesses, federal health officials said Thursday. More than ... prevent measles, mumps, and rubella (MMR); polio; hepatitis B ... Disease Control and Prevention. "Nationally, vaccination among children ...
(Date:8/29/2014)... EDMONTON, AB A new study from the research group ... AB) and the Lawson Health Research Institute (London, ON) has ... of cancer. The study, published in Cell Reports , ... spread of cancer entirely. , Roughly 2 in 5 ... four of them will die of the disease. In 2014, ...
(Date:8/29/2014)... Pittsburgh, PA (PRWEB) August 29, 2014 ... be slippery, especially when wearing socks. Also, many patients ... ambulatory problems, poor balance, surgery recovery, Alzheimer’s, etc. Two ... in order to optimize patient safety. , This special ... medical-facility floors. It also keeps patients who are relegated ...
Breaking Medicine News(10 mins):Health News:LiveOps Supports Muscular Dystrophy Association Show of Strength Telethon 2Health News:LiveOps Supports Muscular Dystrophy Association Show of Strength Telethon 3Health News:LiveOps Supports Muscular Dystrophy Association Show of Strength Telethon 4Health News:Great 100 Honors 13 Novant Health Nurses 2Health News:Most U.S. Babies Get Their Vaccines: CDC 2Health News:Most U.S. Babies Get Their Vaccines: CDC 3Health News:Preventing cancer from forming 'tentacles' stops dangerous spread 2
... , , , , ... and all MinuteClinic medical clinics throughout Arizona are now offering H1N1 ... MinuteClinic locations in Illinois in the Chicago area and in Nevada ... with no appointment necessary. Priority group restrictions have been lifted in ...
... ... tooth whitening procedures. , ... CA (PRWEB) Dec. 21, 2009 -- If you are thinking about giving the gift of ... have all the facts to become a smart shopper of this popular cosmetic process. , ...
... rats when resin was part of diet, study finds , ... in the Middle East -- known as myrrh -- may ... author explained that myrrh resin could be used in conjunction ... not clear yet how people might consume it, and more ...
... , CANTON, Mass., Dec. 21 Organogenesis, Inc. ... (PMA) with the U.S. Food and Drug Administration (FDA) for ... regeneration. If approved, CelTx will be the first, living ... market. , A pioneer in the field, Organogenesis ...
... , CHESTERFIELD, Mo., Dec. 21 ... scientific officer of Reliv International, Inc., was elected to the ... the nation,s leading trade association for the dietary supplement industry. ... control and manufacturing for Reliv, a direct selling company of ...
... , , SANTA CLARA, Calif., Dec. ... in enterprise mobility, today announced that it swept top honors ... MobileVillage® Mobile Star Awards(TM) program, as a result of industry ... and news services about mobile technology. , As in past ...
Cached Medicine News:Health News:CVS/pharmacy and MinuteClinic Now Providing H1N1 Vaccinations in Arizona 2Health News:CVS/pharmacy and MinuteClinic Now Providing H1N1 Vaccinations in Arizona 3Health News:Dreaming of a Whiter Christmas and New Year for Your Teeth? 2Health News:Organogenesis Files PMA for CelTx(TM) for Oral Soft Tissue Regeneration 2Health News:Organogenesis Files PMA for CelTx(TM) for Oral Soft Tissue Regeneration 3Health News:Reliv International's Carl W. Hastings Elected to Board of the Council for Responsible Nutrition 2Health News:Industry Names Agito Networks, Company CTO, FMC Customer to Top MobileVillage Honors for 2009 2Health News:Industry Names Agito Networks, Company CTO, FMC Customer to Top MobileVillage Honors for 2009 3Health News:Industry Names Agito Networks, Company CTO, FMC Customer to Top MobileVillage Honors for 2009 4
(Date:8/29/2014)... WASHINGTON , Aug. 29, 2014 Diseases ... a generation ago are returning. Measles was declared ... cases in 2014 as of August 15—the highest incidence ... public health department declared whooping cough a problem ... children are getting sick and dying from these preventable ...
(Date:8/29/2014)... Ohio , Aug. 29, 2014  In ... how to leverage a hospital pharmacy as a strategic ... and national practice leader for Cardinal Health,s Innovation Delivery ... pharmacy care can benefit both hospitals and patients. ... is only one part of their job in a ...
(Date:8/29/2014)... Pixcelldata, the innovative Irish developer ... a major new deal with Dutch based eX-Path, global ... Dr. Marius Nap . The announcement ... of Pathology which is taking placing between August 30th ... London where Pixcelldata will demonstrate its innovative ...
Breaking Medicine Technology:Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 2Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 4Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2
... landmark trial provide important insight for physicians in treating ... Corporation (NYSE: BSX ) today welcomed the ... this week,s issue of the New England Journal of ... Cardiovascular Research Foundation with research grant support from Boston ...
... over linezolid in resistance acquisition by Staph aureus ... meetingSAN DIEGO, Calif., May 6 Trius Therapeutics, ... the treatment of serious bacterial infections, announced today ... lead program, torezolid (TR-701), will be presented in ...
Cached Medicine Technology:Boston Scientific Welcomes Publication of HORIZONS AMI Trial Results in New England Journal of Medicine 2Boston Scientific Welcomes Publication of HORIZONS AMI Trial Results in New England Journal of Medicine 3Boston Scientific Welcomes Publication of HORIZONS AMI Trial Results in New England Journal of Medicine 4Boston Scientific Welcomes Publication of HORIZONS AMI Trial Results in New England Journal of Medicine 5Trius Therapeutics Announces Presentations Featuring Torezolid Antibiotic at the 19th European Congress of Clinical Microbiology and Infectious Diseases 2Trius Therapeutics Announces Presentations Featuring Torezolid Antibiotic at the 19th European Congress of Clinical Microbiology and Infectious Diseases 3
...
Enables Delicate Lifting Of The Flap Without Causing Trauma - Also available in Titanium...
Khosla Precision and Quality in Medical and Surgical Products....
The CGVL vitrectomy contact glass was designed by Rol, Fankhauser et al. for photodisruptive YAG laser procedures in the posterior vitreous....
Medicine Products: