Navigation Links
Kidneys From Donors Older Than 70 Still Viable

Using them would increase available organs, researchers say,,,,

WEDNESDAY, April 1 (HealthDay News) -- When it comes to kidney donation, you're never too old to give or receive, new research shows.

In a study of kidney transplants from donors who were 70 years old and older, Italian researchers found that after two years, the kidneys appeared to be functioning as well as those from donors who were 10 years younger.

"Ninety-three percent of kidneys from donors over 70 years, and 91 percent of kidneys from donors aged 60 to 69, had grafts [the transplanted organ] that were still functioning at two years after transplantation," said study co-author Dr. Giuseppe Remuzzi, research director of the Negri Bergamo Laboratories at the Mario Negri Institute for Pharmacological Research in Bergamo.

Results of the study were published as a letter in the April 2 issue of the New England Journal of Medicine.

There have been numerous concerns about using organs from older donors, according to Remuzzi. First, doctors worried that kidneys from old or very old donors might not function as long as kidneys from younger donors. Older kidneys would also be more likely to have narrowing of the arteries, which could lead to more surgical complications. And, if there were more surgical complications, that would mean the recipient would need to be under anesthesia for a longer period of time, which would increase risks for the recipient, he explained.

There were also concerns that doing a pre-implantation biopsy, which is necessary to ensure a good match between donor and recipient, might damage an older kidney. Finally, there were also concerns that an older kidney wouldn't be viable for as long between removal and transplant.

But, Remuzzi said a pilot study done 10 years ago found that kidneys from older donors survived well throughout the transplant process. Building off that work, the Italian researchers compared transplant results from 71 people who received one or two kidneys from donors older than 70 to the results of 67 people who received kidneys from people between 60 and 69 years old.

The average age of the recipients was 60, but ranged from 38 to 72 years. Remuzzi said that doctors usually try to keep the age of the donor and recipient to within 10 years. However, there are people who can be difficult to match for blood types and other factors, and doctors may need to use a non age-matched donor for that recipient.

Over an average two-year follow-up period, the researchers found little difference between the two groups of recipients. The group that received kidneys from those over 70 actually fared slightly better in terms of kidney function and survival.

"More than 20 percent of over-65-year-old transplant candidates die every year in the U.S.," said Remuzzi. "Since the survival rate of elderly recipients of a kidney graft is more than double compared to that of age-matched patients remaining on dialysis, accelerating the access to kidney transplant is also expected to extend the life expectancy of this population."

Dr. Mohamed El-Ghoroury is director of transplant services at St. John Hospital and Medical Center in Detroit. He said, "In the U.S., it's very rare to use organs from patients over 70. But, as a clinician, this study may make me look more. The transplant list keeps increasing, and people are dying on the waiting list. In this study, the two-year survival rates were encouraging.

"I think the community in general should know that they don't have to give up on the idea of donation, even if their family member is over 70. They can still save the lives of other people even if they're over 70," he added.

More information

To learn more about kidney transplantation, visit the National Kidney Foundation.

SOURCES: Giuseppe Remuzzi, M.D., research director, Negri Bergamo Laboratories at the Mario Negri Institute for Pharmacological Research, Bergamo, Italy; Mohamed El-Ghoroury, M.D., director, transplant services, St. John Hospital and Medical Center, Detroit; April 2, 2009, New England Journal of Medicine

Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Low Lead Exposures Can Hurt Kidneys
2. Higher-risk kidneys may help solve organ shortage facing older adults
3. Study: Before a CT scan or angiogram, many people should take inexpensive drug to protect kidneys
4. Doctors See How Cancer Drug Can Damage Kidneys
5. Whats wrong with selling kidneys?
6. Male kidneys for men only?
7. Low Doses of Melamine Wont Harm Kids Kidneys
8. New findings on old kidneys could enhance transplants, Stanford study shows
9. Flowers, Hearts and...Kidneys?!
10. Generous Donors Allow Red Cross to Respond Swiftly and Effectively to California Wildfires
11. No increase in cardiovascular risk for living kidney donors
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... "When I underwent ... bras were incredibly uncomfortable," said an inventor from Bronx, N.Y. "In order to ... the patent-pending RECOVERY BRA for added comfort and support. The bra is easier ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch ... solutions involving adult stem cell therapies to patients with chronic degenerative medical conditions. ... as a Registered Trademark (RTM). , Organizations are required to hold a registered ...
(Date:11/24/2015)... ... ... Dr. Todd S. Afferica, a noted general dentist in Norcross, GA , ... now uses the BIOLASE WaterLase iPlus 2.0™ in many of his dental procedures. This ... cutting tools, such as the scalpel and high-speed drill, which can both cause patients ...
(Date:11/24/2015)... Angeles, CA (PRWEB) , ... November 24, 2015 , ... ... explored the different restrictions and variables that determine which patients are or are not ... those patients that have a BMI over 40, are more than 100 pounds overweight, ...
(Date:11/24/2015)... City, UT (PRWEB) , ... November 24, 2015 , ... ... Forbes Magazine. For a business, it is critical that the first impression be positive ... business, they are not likely to buy anything or want to return. They will ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 25, 2015 --> ... eine Lizenz für das Patent über eine neue Hepatitis-B-Behandlung, ... ENS-Lyon innehaben, an Enyo Pharma vergeben haben. ... Leben gerufenen und von Edelris gemeinsam mit seinen Partnern ... Behandlungsziel für HBV identifiziert, und es wurden neue Inhaltsstoffe ...
(Date:11/24/2015)... 24, 2015  Natera, Inc. (Nasdaq: ... testing and the analysis of circulating cell-free ... at the 27 th  Annual Piper Jaffray ... p.m. ET.  Matthew Rabinowitz, Ph.D., CEO of Natera, ... activities and financial outlook.  ...
(Date:11/24/2015)... York , 24. November 2015 /PRNewswire/ ... Avery Breathing Pacemaker Systems, ist erfreut, die ... Clinical Consultant bekannt geben zu können. ...   --> Foto - ... (Schweden). Von 1984-1986 war er ...
Breaking Medicine Technology: