Navigation Links
Kidney tumors have a mind of their own
Date:11/21/2012

TORONTO, Nov. 21, 2012-- New research has found there are several different ways that kidney tumours can achieve the same result namely, grow.

Scientists have been trying to figure out how different people have kidney tumours with the same histology, or shape, although the genetic changes can vary among individual tumours.

Solving that puzzle could have implications for the diagnosis and treatment if kidney cancer, which has 35 per cent mortality rate and is becoming more common. Despite advances in early detection and treatment, the mortality rate hasn't changed in decades.

For the first time, researchers at St. Michael's Hospital have looked at multiple different levels of changes at the same time. Dr. George Yousef, a laboratory pathologist, said researchers have looked at three different ways cancer cells can grow and survive:

the tumour can amplify (or replicate) its chromosomes, the packages of DNA and proteins found in cells

the tumour can alter a process that controls the on-off switch for genes needed for cell growth and differentiation, known as methylation

or the tumour can drive gene activation through another gene

Dr. Yousef said they found that looking at all these changes in the same setting simultaneously can provide a much better understanding of tumour behaviour and how the apparently different changes can produce the same results.

His research appears in the journal Cancer Research, one of the leading journals of in the field of cancer.

Using a high resolution microarray there were also able to identify very specific regions of the chromosomes where genetic alterations happen in kidney cancer to a much higher resolution than before. Combining information from chromosomal changes, methylation and gene expression provided a much clearer understanding of the mechanism of kidney cancer development.

"Now we look at the mechanism rather than the individual change," Dr. Yousef said. "Regardless of the apparent differences of the tumour, the outcome will be the same. Eventually, we may be able to target treatment based on the 'mechanism' that is affected rather than the individual genes that are changed."


'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Related medicine news :

1. Herbal Remedy Ingredient Tied to Cancer, Kidney Failure
2. Specific inhibition of autophagy may represent a new concept for treatment of kidney cancer
3. Kidney cancer patients do better when whole kidney is not removed, U-M study shows
4. Role of Screening, Monitoring in Early Kidney Disease Unclear
5. Kidney Cancer Patients Fare Better With Tumor Removal Only
6. Donor Kidney Re-Used in Second Patient After Failing in First
7. Routine Kidney Disease Screening Not Worthwhile, Experts Say
8. Surprising results for use of dialysis for kidney failure in developing world
9. Everyday fish oil capsule may provide kidney-related benefits
10. First, Second Kidney Transplants Have Similar Success: Study
11. Women fare better than men, but need more blood after kidney cancer surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... The doctors ... Richmond, BC, who live with dental fear and require sedation to receive dental care. ... at ease during various procedures, from hygienic cleanings to oral surgery, at their dental ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... ... choose a modern procedure that achieves results in a fraction of the time ... Las Vegas, NV, with Significance Dental Specialists, now offers this revolutionary treatment with ...
(Date:4/25/2017)... ... 25, 2017 , ... As Spring reignites vigilance against Zika ... to Zika virus during pregnancy, as well as other prenatal exposures like cocaine, ... , The Teratology Society is an international and multidisciplinary group of ...
(Date:4/25/2017)... ... April 25, 2017 , ... Buyers and sellers in the thriving multi-billion dollar ... shops –can’t help but be heartened by the industry’s current surge. But another thing ... as “skunk smell.” At last they can simply, safely and effectively end their ...
(Date:4/25/2017)... ... 25, 2017 , ... Somnoware, a leading provider of digital ... module. Using this new feature, sleep physicians can now predict the likelihood of ... airway pressure (CPAP), oral, or other forms of sleep apnea therapy. The Somnoware ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)...  IRIDEX Corporation (Nasdaq: IRIX ) today ... first quarter 2017 after the close of trading on ... host a corresponding conference call beginning at 2:30 p.m. ... in listening to the conference call may do so ... 326-3030 for international callers, using conference ID: 92158987.  A ...
(Date:4/19/2017)... , April 19, 2017 Global Prostate ... report on the prostate cancer therapeutics market analyzes ... market. Increasing prevalence of prostate cancer, launch of ... the development of new drugs & therapeutic biological ... drug due to lesser side effects are some ...
(Date:4/19/2017)... The Global Effective Microorganisms (EM) Market ... has covered and analysed the potential of Global Effective Microorganisms ... shares and growth factors. The report identifies and analyses the ... the global market. ... 152 Tables and Figures, 6 Major Company Profiles, spread across ...
Breaking Medicine Technology: