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Kidney donor age linked to aortic siffening
Date:2/21/2008

rgeted interventions after kidney transplantation, with the goal of reducing cardiovascular risk and mortality and improving long-term results. "Early identification of patients with worsening arterial disease following transplantation would mean that they could benefit from drug treatments to reduce arterial stiffness," says Dr Delahousse. Further studies would be needed to determine whether this strategy improves the overall outcomes of kidney transplantation.

The findings also provide an intriguing new piece of evidence regarding the complex interrelationships between the kidneys and cardiovascular system. "Our study provides the first strong cause-and-effect evidence of the impact of kidney characteristics upon the mechanical properties of large arteries," states Dr. Delahousse. "The results suggest that the kidney could be involved, normally or otherwise, in the process of arterial stiffening that is the hallmark of aging of the large arteries."

The results do not question the increasingly common practice of transplantation from expanded criteria donors (ECD). These donors have certain characteristicssuch as older age, high blood pressure, or slightly decreased kidney functionthat make them less than ideal as organ donors. Dr. Delahousse emphasizes: "In the current context of organ shortage, ECD transplantation confers a significant survival advantage compared to remaining on dialysis, even if only under certain conditions."

The researchers acknowledge some limitations of their study, including its small size and a potential but "reasonably low" risk of selection bias.


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Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
Source:Eurekalert

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