Navigation Links
Kidney damage and high blood pressure
Date:9/22/2011

Bethesda, Md. (Sept. 22, 2011) The kidney performs several vital functions. It filters blood, removes waste products from the body, balances the body's fluids, and releases hormones that regulate blood pressure. A number of diseases and conditions can damage the kidney's filtration apparatus, such as diabetes and immune disorders. This damage leads to a condition called nephrotic syndrome, which is characterized by protein in the urine, high cholesterol and triglycerides, and swelling (edema). People with nephrotic syndrome retain salt and water in their bodies and develop swelling and high blood pressure as a result.

Scientists have now begun to understand kidney damage on a cellular level and how the activity of certain molecules in damaged kidneys contributes to salt and water retention in nephrotic syndrome. Several new insights in this area of research will be presented at the7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels, being held September 18-22 in Pacific Grove, Calif. The meeting is sponsored by the American Physiological Society.

Faulty Filtration

The kidneys are marvels of filtration, processing roughly 150 to 200 quarts of blood each day through tiny structures called nephrons. There are about 1 million nephrons per kidney, and each nephron consists of a filtering unit of blood vessels called a glomerulus, which is attached to a tubule. Filtered blood enters the tubule, where various substances are either added to or removed from the filtrate as necessary, and most of the filtered sodium and water is removed. The filtrate that exits the tubule is excreted as urine.

In nephrotic syndrome, a damaged filtration barrier allows substances that are not normally filtered to appear in the filtrate. One of these substances is the protein plasminogen, which is converted in kidney tubules to the protease plasmin. In their research, Thomas R. Kleyman, Professor of Medicine and of Cell biology and Physiology at the University of Pittsburgh School of Medicine and the Symposium's co-organizer, and Ole Sktt, Professor of Physiology and Pharmacology and Dean at the University of Southern Denmark in Odense, independently found that plasmin plays a role in activating the epithelial sodium channel (ENaC) on cells in the nephron. ENaC is a protein embedded in cell membranes that facilitates the absorption of filtered sodium from tubules. When ENaC is becomes overactive, excessive absorption of filtered sodium may lead to sodium and water retention.

According to Dr. Kleyman, these findings provide an explanation of how damage to the glomeruli in the kidney's nephrons leads to edema and high blood pressure. Dr. Kleyman explains: "When plasminogen is cleaved, it can act on several targets. One of those targets is ENaC. Another is the protein prostasin, which, once cleaved, will activate ENaC, as well."

Dr. Kleyman noted the implications these findings have for treating edema and high blood pressure in patients suffering from nephrotic syndrome. "This is important because if plasmin activates ENaC, it suggests that targeting ENaC in the kidneys with ENaC inhibitors may be a treatment option."


'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Related medicine news :

1. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
2. New drug for kidney transplant recipients effective in humans
3. Drug for advanced kidney cancer shrinks tumors prior to surgery
4. Obesity -- mild or severe -- raises kidney stone risk
5. VARI findings may help patients with deadly kidney cancer
6. Kidneys From Older Donors Suitable for Seniors
7. Comparison shows robot-assisted option offers advantages for kidney surgery
8. Walk KidneyWise Los Angeles to Help Launch KidneyWise with Fundraising Walk in Santa Monica
9. Board Certified Renal Specialist, Nina Kolbe, Publishes Second Edition of Kidney Health Gourmet: A Diet Guide and Kidney Friendly Recipes for People Not on Dialysis
10. American Kidney Fund Raises Awareness, Honors Kidney Heroes during National Kidney Month
11. National Kidney Month 2010: Stories of Hope About the Prevention and Maintenance of Kidney Disease from The Kidney TRUST
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... ... a highly specialized asset-light logistics provider of complex transport solutions for mission-critical ... to purchase Unitrans International Corporation, a division of Roadrunner Transportation Systems, Inc. ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Dawn Johnson Insurance Group, a Missouri-based insurance ... to generate community support for efforts to educate the local population on cancer realities ... types of cancer. , Each day in America, roughly 4,600 new cases of ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Brian Gifford Agency, an Indiana-based firm providing ... support of Campagna Academy in a charity drive to provide for at-risk children and ... Indiana,” Campagna Academy is a nonprofit organization that has offered critical programs to at-risk ...
(Date:8/18/2017)... ... August 18, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in ... veil on false teachings pertaining to the mother of the Savior whom the world calls ... far different picture of the role of this historical woman. , “The world bows, ...
(Date:8/18/2017)... ... 18, 2017 , ... “Dangerous Inheritance”: a mystery about saving the family farm. ... from Southwest Nebraska where she was raised on a farm. As Diane wrote ... fictional, but the friendships and mantra of ‘neighbors helping neighbors’ have always been a ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... -- The search for test results that can be ... long been the goal of healthcare providers and the ... largest meeting of lab professionals and IVD firms this ... Kalorama Information.  The firm said scores of companies with ... and software were at the American Association for Clinical ...
(Date:8/2/2017)... Fenita J. Caldwell is ... Lifetime Professional in the Field of Healthcare. Caldwell ... Pharmaceuticals, AG. Her skills and areas of expertise ... Fenita ... experience as a highly successful sales specialist in ...
(Date:8/2/2017)... Aug. 2, 2017 CaryRx, a next-generation full-service pharmacy, ... service for patients in the Washington D.C. ... pharmacy by providing delivery of medications through the convenience of ... delivery or delivered within one hour to any location in ... to bring this invaluable service to Washington D.C. ...
Breaking Medicine Technology: