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Kidney cancer subtype study finds low recurrence and cancer death rates
Date:3/29/2012

vely. The cancer-specific survival rates after surgery were 87.9% at five years and 83.3% after ten years.

  • Multivariable analysis, which determines the relative contributions of different causes to a single event, identified three independent predictors of recurrence-free survival rates. These were: Fuhrman nuclear grade (predictive grading system for renal cell cancer), N stage (coding system indicating absence or presence of secondary cancer in the regional lymph nodes) and M stage (coding system indicating absence or presence of distant secondary cancers at first therapeutic intervention).

  • In this study 60% of patients were N stage pNx (regional nodes cannot be assessed), 97% were M stage MO (no indication that cancer has spread to distant parts of the body), 52% were Fuhrman grade G2 (low grade in a grading system of one to four) and 10% of patients had tumours at multiple sites.

  • Fuhrman nuclear grade was found to be a particularly strong predictor of both recurrence-free and cancer-specific survival rates. In contrast, only a non-statistically significant trend was found for the 2009 pathological T stage (coding system that identifies the presence, size and extent of a primary tumour).

    "Our multi-centre study shows that patients with papillary renal cell carcinoma face low tumour re-occurrence and cancer-related death rates" concludes Dr Ficarra. "It also identifies the main independent predictors of cancer-related outcomes as being pathological lymph node stage, presence of secondary cancer and Fuhrman nuclear grade."


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  • Contact: Annette Whibley
    annette.wizard@gmail.com
    Wiley-Blackwell
    Source:Eurekalert

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