Navigation Links
Kidney cancer reveals its weak link
Date:2/18/2014

A team of researchers at Chalmers University of Technology has found that kidney cancer cells have a quite different metabolism than other types of malignancies. The findings pave the way for new methods of diagnosing kidney cancer at an early stage, a feat that had eluded researchers earlier, and thereby fresh approaches to treatment.

Cancer is a result of mutations in the genes of healthy cells. The transition to cancer cells involves a fundamental transformation of their metabolism, the way that they use nourishment and energy. The uninhibited growth of cancer cells is based on their particular metabolism.

The Chalmers researchers have explored the metabolism associated with ten types of cancer cells. When analyzing regulation of metabolism by healthy cells after having become malignant, the researchers made an unexpected discovery.

"One type of cancer stood out from all the rest," says Professor Jens Nielsen, who headed up the team. "Cells affected by kidney cancer reprogram their metabolism in a very special way, which is the weak link in the disease. What fascinated us most was that we can potentially measure this vulnerability by taking a simple blood sample."

In order to look more closely at possible methods of using metabolism to diagnose renal cell carcinoma the most common type of kidney cancer the Chalmers team has begun collaborating with researchers at a hospital in Padua, Italy.

"To determine whether our predictions are valid," Professor Nielsen says, "the hospital will conduct a clinical trial to analyze blood samples and urine specimens from kidney cancer patients. We anticipate that a simple method of deciding whether someone has kidney cancer will be available within a few years."

Early detection of kidney cancer significantly improves its prognosis. Surgery to prevent the malignancy from metastasizing can still be successful at that point. The study also suggests that a feasible long-term goal is the ability to destroy cancer cells by changing their metabolism.

"Because kidney cancer cells metabolize abnormally, they have to fight for their survival," says Francesco Gatto, who constructed the cell models. "As a result, it should be possible to customize a way of taking advantage of their vulnerabilities so as to kill them without damaging healthy cells."

With that idea in mind, the Chalmers team is also collaborating with British researchers to identify the mechanisms decisive to destroying kidney cancer cells. The objective is to discover and develop drugs that can attack renal cell carcinoma.


'/>"/>

Contact: Christian Borg
christian.borg@chalmers.se
46-317-723-395
Chalmers University of Technology
Source:Eurekalert  

Related medicine news :

1. Herbal Remedy Ingredient Tied to Cancer, Kidney Failure
2. Specific inhibition of autophagy may represent a new concept for treatment of kidney cancer
3. Kidney cancer patients do better when whole kidney is not removed, U-M study shows
4. Role of Screening, Monitoring in Early Kidney Disease Unclear
5. Kidney Cancer Patients Fare Better With Tumor Removal Only
6. Donor Kidney Re-Used in Second Patient After Failing in First
7. Routine Kidney Disease Screening Not Worthwhile, Experts Say
8. Surprising results for use of dialysis for kidney failure in developing world
9. Everyday fish oil capsule may provide kidney-related benefits
10. First, Second Kidney Transplants Have Similar Success: Study
11. Women fare better than men, but need more blood after kidney cancer surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Kidney cancer reveals its weak link
(Date:6/22/2017)... ... June 22, 2017 , ... United Benefit ... welcome Whipple & Company as its newest Partner Firm. Headquartered in Coconut Creek, ... clients’ risk while tailoring optimized benefit packages that strengthen the relationship between employer ...
(Date:6/22/2017)... ... June 22, 2017 , ... Children’s National ... Heart Association (AHA) to launch a Rheumatic Heart Disease Center, with the goal ... of rheumatic heart disease (RHD) in high-risk, financially disadvantaged countries and low-income communities ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... environmental excellence. Maryland Recycling Network has awarded the Baltimore VA Medical Center, a ... Government Program Award for its efforts to promote waste reduction and promote recycling. ...
(Date:6/22/2017)... ... ... A June 12 article in The Star offers the advice ... oral hygiene by an aged parent who had recently suffered a series of minor ... steps, including scheduling a dentist visit. Northridge Dental Works, a Los Angeles Area dental ...
(Date:6/20/2017)... Murfreesboro, Tennessee (PRWEB) , ... June 20, 2017 ... ... chronic care services, announced today that Claritas Capital, a Nashville-based private equity firm, ... to accelerate our expansion plans for some time, and Claritas Capital offers the ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... 2017 Therapix Biosciences Ltd. (Nasdaq: TRPX), ... the development of cannabinoid-based drugs, today announced that ... at three upcoming scientific and investor conferences in ... Invitational: ...                     Wednesday, June ...
(Date:5/26/2017)... , May 26, 2017  Endo International plc (NASDAQ: ... President and CEO, will represent the Company in a fireside ... Conference on Tuesday, June 13, 2017 at 10:40 a.m. PT ... Terranea Resort in Rancho Palos Verdes, CA. ... the event will be available on the Company,s website at ...
(Date:5/24/2017)... , May 24, 2017  ivWatch LLC ... Equipment Manufacturer (OEM) Board to enable seamless integration ... patient monitoring systems, infusion pumps and other devices. ... will be able to help health care customers ... reduced risks related to IV therapy. ...
Breaking Medicine Technology: