Navigation Links
Kidney cancer patients do better when whole kidney is not removed, U-M study shows
Date:4/17/2012

ANN ARBOR, Mich. Kidney cancer patients who had only their tumor removed had better survival than patients who had their entire kidney removed, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.

After an average of five years, 25 percent of patients who had a so-called partial nephrectomy, in which only the tumor and a small margin of healthy tissue is removed, had died, while 42 percent of patients who had radical nephrectomy, in which the entire kidney is removed, had died, the study found. Results appear in the April 18 Journal of the American Medical Association.

"For patients who are candidates for partial nephrectomy, it should be the preferred treatment option. We found that patients who were younger or had pre-existing medical conditions benefited most from partial nephrectomy," said lead study author Hung-Jui Tan, M.D., a urology resident at the U-M Medical School.

The researchers looked at 7,138 Medicare beneficiaries with early stage kidney cancer up to eight years after treatment. Patients were equally likely to die of kidney cancer, regardless of the type of surgery they received, suggesting that each procedure was equally likely to cure the cancer. The survival discrepancy was found in the number of patients who died from any cause.

The study showed that if only seven patients chose partial nephrectomy over radical nephrectomy, it would save one extra life.

Early stage kidney cancers have become more common recently. These are often discovered by chance when patients receive an X-ray or CT scan for something unrelated.

"As more and more people are identified with these small, early stage cancers, there's more interest in understanding how best to treat these patients," says senior study author David C. Miller, M.D., M.P.H., assistant professor of urology at the U-M Medical School and member of U-M's Institute for Health Care Policy and Innovation.

The question, though, is whether partial nephrectomy which is a more technically challenging procedure and potentially associated with more short-term complications is preferable to radical nephrectomy. Removing a kidney can increase the risk of chronic kidney disease, which is associated with lipid disorders, cardiovascular disease and renal failure.

The debate is similar to breast cancer surgery, in which studies have found that lumpectomy plus radiation is comparable to mastectomy. While that choice often comes down to a cosmetic trade-off, the trade-off with kidney cancer is a potential higher risk of short-term complications with partial nephrectomy vs. avoiding chronic kidney disease in the long term.

"This study does not suggest every patient with early stage kidney cancer should get a partial nephrectomy. It supports the notion that we need to expand the use of partial nephrectomy and make it a preferred treatment choice for patients with small tumors as much as possible, to optimize long term survival," Miller says.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Specific inhibition of autophagy may represent a new concept for treatment of kidney cancer
2. Herbal Remedy Ingredient Tied to Cancer, Kidney Failure
3. Kidney cancer subtype study finds low recurrence and cancer death rates
4. Stem Cell Therapy Could Boost Kidney Transplant Success: Study
5. Study targets key molecule to reverse kidney damage in mice
6. High blood glucose levels may increase kidney disease in elderly populations
7. First study of its kind finds no increased risk of heart disease for kidney donors
8. Weight-Loss Surgery Seems Safe for Kidney Disease Patients
9. Dieting Can Prove Dangerous for Kidney Disease Patients
10. More Kidney Dialysis Is Better, Research Finds
11. Kidney Damage Greatly Raises Diabetics Risk for Death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... Charlottesville, Virginia (PRWEB) , ... January 18, 2017 , ... ... New studies are released almost daily linking gut health to chronic disease, mental health ... the New Year ” as an important resolution to consider. , For one Charlottesville ...
(Date:1/18/2017)... ... 2017 , ... The VA Maryland Health Care System and ... project focused on multiple sclerosis (MS). Led by Christopher M. Jewell, PhD, an ... disease without compromising normal immune function that often occurs during autoimmune diseases. Ultimately ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... most-read publication among specialty pharmacists and pharmacy professionals, has teamed up with ... Partnership (SAP) program, announced Brian Haug, president of Pharmacy Healthcare Communications, LLC, ...
(Date:1/18/2017)... ... January 18, 2017 , ... A Palm Beach doctor plans to run the ... charity that provides free surgery to poor children suffering from cleft lip and cleft ... have run to support the efforts of the American Heart Association and the Leukemia ...
(Date:1/18/2017)... ... January 18, 2017 , ... The Portee Insurance Agency, a ... business owners in central Maryland and the DC region, is inaugurating a charity event ... people nationally every year, making it the #1 killer in America. However, heart disease ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Jan. 19, 2017 Accuray Incorporated (Nasdaq: ... TomoTherapy® Systems continue to set the bar for excellence ... composite overall user satisfaction rating among radiation treatment delivery ... MD Buyline Market Intelligence Briefing™. The most recent ratings ... ratings among industry peers for 11 of the past ...
(Date:1/19/2017)... , Jan. 19, 2017 ViewRay, Inc. (Nasdaq: ... federal institution supporting research in Germany ... patient treatments at the University Clinic Heidelberg as part ... The MRIdian Linac program will be headed by Medical ... heads radiation oncology at the German Cancer Research Center ...
(Date:1/19/2017)... -- New Review of Safinamide - ... and Motor Complications in Mid- to Late-stage Parkinson,s ... ... C Warren Olanow , ... 2-15, http://www.touchneurology.com/articles/safinamide-new-therapeutic-option-address-motor-symptoms-and-motor-complications-mid-late Published recently ...
Breaking Medicine Technology: