Navigation Links
Kidney advocates launch $10.25 million effort to examine cause of kidney failure
Date:9/22/2009

University of Michigan Health System researchers will lead a $10.25 million effort to study rare kidney diseases that cause kidney failure and the need for dialysis.

The five-year project supports research of nephrotic syndrome, which describes a group of diseases that, though rare, generates an enormous individual and societal burden. The syndrome, which affects kidney filter cells, contributes to nearly 12 percent of cases of kidney failure, and an annual cost of more than $3 billion.

The Nephrotic Syndrome Rare Disease Consortium will bring together a network of investigators from the United States and Canada, and two highly active patient interest groups, the Nephcure Foundation and the Halpin Foundation, to create a network for collecting patient information, facilitating clinical and observational studies and training future researchers.

The National Institutes of Health Office of Rare Diseases, the National Institutes of Diabetes, Digestive and Kidney Disease awarded a $6.25 million grant to the U-M, with NephCure committing $2 million and U-M contributing a total of $2 million.

NephCure, a Pennsylvania-based patient advocacy and research funding organization, will continue to have a role in recruiting and educating patients. NephCure has contributed more than $6 million to research over the past several years.

"The kidney community has had a strong interest in this work for a long time, but, until now, we have not had adequate funding for a coordinated effort," says project director Matthias Kretzler, M.D., professor of internal medicine at the U-M Medical School and a nephrologist at the U-M Health system.

"This has the potential to change the way we understand and treat patients with nephrotic syndrome," he says. "NephCure's support was critically important in winning this award and will be vital to our long term success."

Kretzler, along with U-M medical school researchers Akinlolu Ojo, M.D., Ph.D., professor in internal medicine, and Lawrence B. Holzman, M.D., professor of internal medicine, will provide the leadership for the multi-center consortium.

"As a premier research institution, we're well-positioned to take advantage of a rapidly expanding knowledge of genetics and the power of bioinformatics to transform our understanding and treatment of rare diseases," says James Shayman, M.D., associate vice president for research at the University of Michigan.

"We recognize that combining our own institutional resources with those of the NIH and NephCure Foundation creates a unique opportunity for promoting rare disease research in nephrotic syndrome," he says.

A seed grant from the university's Office of the Vice President for Research Rare Disease Initiative was instrumental in securing funding for the new consortium.

While the U-M will function as the central operational hub, clinical investigators from 11 academic medical centers will make up the research team.

One of the joint initiatives will be to establish and maintain a Web site with educational and networking resources for patients, families, physicians and scientists.

Researchers will investigate minimal change disease, focal and segmental glomerulosclerosis, and membranous nephropathy, diseases known to damage kidney filter cells and can lead to kidney failure and death.

Some types of the syndrome are hereditary, but it can also manifest later in life for reasons largely unknown. The network will use molecular medicine tools to unravel the mechanism responsible for the diseases and potentially develop new targeted treatment therapies.


'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Diet, Exercise May Slow Kidney Disease Progression
2. Kidney Transplant at 84, Chicago Artist Proves New Start Possible at Any Age
3. Extended Antiviral May Benefit Kidney Transplant Patients
4. Satellite Healthcare Helps Support the Cure for Kidney Disease in Sacramento
5. September 2009 Mayo Clinic Health Letter Highlights Snoring, Kidney Stones and Vitamin D
6. Kidney Injury While Hospitalized May Lead to Future Dialysis
7. New Data Shows DaVita Facilities Lead Virginia in Improving Kidney Patient Care
8. DaVita Launches Nationwide Series of Kidney Awareness Run/Walks
9. Success of National Fundraising Event Critical to Promising Research for Life-Threatening Kidney Disease
10. DaVitas Patient-Centric Modalities Offer Students with Kidney Disease More Choices
11. Texas Kidney Community Expresses Hope DC Health Care Reform Debate Can Help Drive Continued Progress in Texas Opening Needed Dialysis Facilities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along ... updates for the primary prevention of cardiovascular diseases during the 15th Annual ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of ... part of a disaster drill on October 3rd. , Apple Rehab participated with the ... as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The ...
(Date:10/13/2017)... BASKING RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... second annual Holly Day Market. Featuring a collection of specialty vendors and unique items ... myriad of personalized and quality-focused health and wellness services offered by the VNA. ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... COPENHAGEN, Denmark , Oct. 2, 2017 The ... tool in the struggle to reverse the tide of prescription ... plan for regulating their medicine intake and stepping down their ... is set to launch in December 2017; the first 100,000 ... access. Learn more at http://www.rebound-solution.com/ ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/19/2017)... a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed ...   ... Jim Bertolina, ... Tom Tefft ... medical device executive Josh Stopek , PhD, who has led R&D and business development ...
Breaking Medicine Technology: