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Kidney Week 2013: New innovations in clinical science
Date:11/9/2013

Atlanta, GA (November 9, 2013)A variety of recent studies highlight new and innovative research efforts that could help improve individuals' kidney health. Below are the findings of some of these studies, which are being presented at ASN Kidney Week 2013 November 5-10 at the Georgia World Congress Center in Atlanta, GA.

In one study,* Linda Fried, MD, FASN (VA Pittsburgh Healthcare System) and her colleagues examined the effects of combination therapy with two types of blood pressurelowering drugs: angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB). The combination is known to decrease protein excretion in the urine, which is a marker of kidney dysfunction, but its safety and impact on progression of kidney disease is uncertain. In this latest study, 1148 patients with type 2 diabetes who had moderately decreased kidney function were treated with the ARB losartan and then randomized to receive the ACE inhibitor lisinopril or placebo.

  • After a midpoint follow-up of 2.2 years, significant kidney function decline occurred in 152 patients in the monotherapy arm and 132 in the combination arm. There was no benefit on mortality or cardiovascular events.
  • "The study was stopped early by the data monitoring committee as they concluded that the risks of combination therapy outweighed a small possible benefit on progression of kidney disease, though not statistically significant," said Dr. Fried. The main risks were a 1.7-fold higher risk of acute worsening of kidney function and a 2-fold higher risk of elevated potassium levels in the blood. Individuals on combination therapy also had a higher rate of hospital admissions.

*Additional data from this study are available in the following Late-Breaking Posters: Risk and Severity of Hyperkalemia with Combined Angiotensin Antagonism in Diabetic Nephropathy The VA-NEPHROND Study (SA-PO1089); and Acute Kidney Injury (AKI) Associated with Combined Angioten
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Contact: Kurtis Pivert
kpivert@asn-online.org
202-699-0238
American Society of Nephrology
Source:Eurekalert

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