Navigation Links
Kiadis Pharma Announces ATIR Interim Clinical Results
Date:10/10/2007

Successful Independent Clinical Evaluation of ATIR by Dr. Velardi for

Mismatched Bone Marrow Transplantation

AMSTERDAM, Netherlands, Oct. 10 /PRNewswire/ -- Kiadis Pharma today announced interim results of a physician initiated European Phase II clinical study for its lead product ATIR. Professor Velardi from the University of Perugia in Italy presented the successful treatment of thirteen end stage blood cancer patients with a mismatched bone marrow transplantation during the 5th workshop on "Haploidentical Stem cell Transplantation" in Catania, Italy. The results are an important milestone in the development of ATIR as a revolutionary approach to provide a safe and potentially life-saving mismatched bone marrow transplantation as treatment option for end-stage blood cancer patients.

Bone marrow transplantations are currently limited because of the high risk of Graft versus Host Disease (GvHD). This is a severe and potentially life-threatening complication in which the donor immune cells recognize and attack the patient's tissues and organs. Therefore it is currently essential that the patient and donor blood systems (the human leukocyte antigens, HLA) are highly similar in order to reduce the chance of acute GvHD. As a consequence, bone marrow transplantations strongly rely on the availability of a matching donor. However, the timely availability of a matching donor is a limiting factor for many patients to receive a bone marrow transplantation. Kiadis Pharma's ATIR is under development to prevent acute GvHD by elimination of the immune cells causing acute GvHD. A successful development would enable the performance of mismatched donor transplantations, including donor immune cells that can fight infections and the cancer without causing GvHD complications. Because ATIR eliminates acute GvHD causing cells, the transplantation can be performed without the currently standard immune suppressant regime post transplantation. This subsequently allows the donor immune system to rapidly develop helping the patient to fight infections, another major life threatening complication of bone marrow transplantations.

Professor Velardi, a key opinion leader in the field of mismatched allogeneic transplantations, has presented the clinical results of thirteen end stage blood cancer patients who received bone marrow transplants from mismatched donors, including donor immune cells that are selectively depleted of acute GvHD causing cells using ATIR. No immune suppressants were used post transplantation as a standard regime. No patient has developed lethal acute Graft versus Host Disease, the major complication that prohibits the use of this treatment without ATIR. The patients rapidly developed a new donor immune system as assessed by the rapid expansion of immune cells in the patients. Detailed analysis revealed the presence of pathogen specific donor immune cells in the patients. In particular immune cells recognizing pathogenic fungi, like Aspergillus and viruses like Cytomegalovirus (CMV) could be detected post transplantation.

These specific pathogens are the major cause of death by infections after bone marrow transplantation. This shows that the ATIR treated immune cells are functional and could fight infections without causing lethal acute GvHD in these patients.

"Bone marrow transplantations are often the only treatment option left for end-stage blood cancer patients. But too many patients simply do not find a suitable matched donor in time," said Dr. Andrea Velardi, M.D., Professor of Clinical Immunology at the University of Perugia. "The interim results of our study show a rapid immune reconstitution in transplanted patients provided with ATIR treated immune cells from mismatched donors. Without ATIR treatment this would not be possible because of the high risk of acute Graft versus Host Disease (GvHD) with mismatched donor immune cells. This is obviously a very hopeful development for a large patient group."

The physician initiated European ATIR Phase II trial by Prof. Andrea Velardi, M.D. is the second clinical trial of ATIR for mismatched bone marrow transplantations. Kiadis Pharma conducts a company-sponsored trial ongoing in North America. Both trials aim to investigate the potential of ATIR to make the use of a mismatched bone marrow transplantation a feasible treatment for blood cancer patients who are not responding to other treatments and who do not have access to a matched donor in time. For these patients ATIR can enable a potentially life-saving transplantation.

"The broad endorsement of ATIR by key opinion leaders in this field is exemplified by the initiative of Professor Velardi," commented Dr. Manja Bouman, CEO Kiadis Pharma. "These excellent results in the Perugia trial provide Kiadis Pharma with important external validation."

About ATIR

ATIR is being developed to enable the use of a mismatched donor for an allogeneic bone marrow transplantation for end stage blood cancer patients. ATIR selectively eliminates from a mismatched graft the immune cells that cause acute Graft versus Host Disease, a severe and potentially lethal complication with allogeneic bone marrow transplantations.

About Kiadis Pharma

Kiadis Pharma is an oncology focused pharmaceutical development company with four products in different phases of clinical development. The company develops products that offer novel treatment options for terminally ill cancer patients and address high-unmet medical needs. The key focus indication for Kiadis Pharma is limitations and complications of bone marrow transplantation procedures performed in blood cancer patients. Kiadis Pharma is headquartered in Amsterdam, the Netherlands with facilities in Groningen, The Netherlands and Montreal, Canada. For more information about Kiadis Pharma, please visit http://www.kiadis.com.


'/>"/>
SOURCE Kiadis Pharma B.V.
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. India to benefit from pharma companies move
2. South Africa Wins landmark case against pharmaceutical giants
3. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
4. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
5. Pharma cos must forge Strategic alliances
6. Jharkhand Pharmacies Refuse To Sell Viagra
7. Setting up a new pharmaceutical industry in India
8. Medicis Pharmaceutical company enters pediatric market
9. Supply of Radiopharmaceuticals Hampered by Attacks
10. Pharma majors gear to supply anti-anthrax drug
11. Pharmacies in for a dose of bitter medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... MD (PRWEB) , ... March 29, 2017 , ... ... is proud to announce the finalization of the company’s executive management team with prominent ... and leading operations is Curio Wellness’ Chief Operating Officer, Ted Dumbauld , who ...
(Date:3/29/2017)... Linda, Ca (PRWEB) , ... March 29, 2017 , ... ... of a growing number of cancers and is touted to be the next revolution ... treatment, thus far, has been in the form of immune checkpoint inhibitors such as ...
(Date:3/29/2017)... ... 29, 2017 , ... The Wharton School of the University of Pennsylvania is ... made a $10 million gift to establish the Ken Moelis and Julie Taffet ... to a Wharton MBA for highly-qualified Penn undergraduates whose academic and career interests expand ...
(Date:3/28/2017)... CA (PRWEB) , ... March 28, 2017 , ... Tuesday, ... asking the American public to take the Diabetes Risk Test to find out if ... the Los Angeles World Airports will light up the evening sky by programming the ...
(Date:3/28/2017)... ... March 28, 2017 , ... Resoundant, ... be invited to the Siemens Healthineers annual customer education symposium, a world-class learning ... take place from March 27 - 31, 2017 at the Atlanta Marriott Marquis ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... Research and Markets has announced the addition of the ... to their offering. ... The ablation device global market is expected to grow at ... Ablation is the minimally invasive therapeutic tissue excision procedure ... tissue removal, to the removal of abnormally conducting cardiac tissue in ...
(Date:3/29/2017)...   Royal Philips (NYSE: PHG, AEX: ... PathAI, a company that develops artificial intelligence technology ... develop solutions that improve the precision and accuracy ... The partnership aims to build deep learning applications ... intelligence to be applied to massive pathology data ...
(Date:3/29/2017)... , March 29, 2017 On March 28, the U.S. ... adult patients with relapsing forms of multiple sclerosis (MS) ... first drug approved by the FDA for PPMS. Ocrevus ... professional.  "Multiple sclerosis can have a ... Dunn , M.D., director of the Division of Neurology ...
Breaking Medicine Technology: