Navigation Links
Key to longer life (in flies) lies in just 14 brain cells
Date:9/20/2007

PROVIDENCE, R.I. [Brown University] -- Two years ago, Brown University researchers discovered something startling: Decrease the activity of the cancer-suppressing protein p53 and you can make fruit flies live significantly longer.

Now the same team reports an intriguing follow-up finding. The p53 protein, they found, may work its lifespan-extending magic in only 14 insulin-producing cells in the fly brain.

Its quite surprising, said Johannes Bauer, a postdoctoral research fellow at Brown. In the fruit fly brain, there are tens of thousands of cells. But we found that it takes a reduction of p53 activity in only 14 of those brain cells to extend lifespan. It was like finding a needle in the haystack a very small needle at that.

Bauer is the lead author of the research report, published in the Proceedings of the National Academy of Sciences. Brown biology professor Stephen Helfand, senior scientist on the project, will discuss the findings in his keynote address at the Gordon Research Conferences on the Biology of Aging, to be held Sept. 23-28, 2007, in Les Diablerets, Switzerland.

P53 is sometimes called guardian of the genome for defending cells against DNA damage. Not enough of the protein can cause cancer; too much, however, can shorten lifespan. But in 2005, Helfand and his lab showed that a targeted decrease of p53 in fruit flies a decrease specifically in their brain cells allowed flies to live healthy lives that were as much as 58 percent longer.

But how, exactly, does p53 do its work in the brain" To find out, Bauer spent a year conducting painstaking experiments. Hed take a batch of young flies, each genetically altered to reduce p53 activity in a small portion of their nervous systems, and watch the flies age. Time and again, the flies lived for about two months the average lifespan for these insects.

But when Bauer manipulated a cluster of 14 insulin-producing cells in their brains, the flies l
'/>"/>

Contact: Wendy Lawton
Wendy_Lawton@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New breed of mice to live longer
2. And now its super mice for longer memory
3. Patients In Ontario Wait Longer For Treatment
4. Longer airway in males increases sleep disorder risk
5. Treatment over a longer period for blood clotting
6. Dads to blame for longer pregnancies
7. Longer Lung Cancer Survival
8. Meditation may reduce stress and help you live longer
9. Patients Are Given Catheter Longer Than Necessary
10. Good news for those of you wanting to live longer
11. Intelligent children had longer live
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... San Diego, Calif. (PRWEB) October 30, 2014 ... no longer mutually exclusive concepts in the medical-grade ... focusing on the development of uniquely potent topical ... Skin Health System ( http://www.RefinitySkinScience.com ) with patented ... highest available glycolic acid concentrations (50% and 70%) ...
(Date:10/30/2014)... 2014 PreDiabetes Centers , the ... shoppers with a supply of sugardown®, a chewable ... post-meal blood sugar spikes. Learning how to control blood ... part of a diabetes prevention plan. , Shoppers who ... complimentary tube of sugardown. The offer expires November 30. ...
(Date:10/30/2014)... CT (PRWEB) October 30, 2014 Radio ... are raising questions about the impact of traditional radio ... marketing method most likely to influence a purchasing decision. ... poll of 525 consumers conducted by radio marketing company ... product categories, isolating the results of respondents who indicated ...
(Date:10/30/2014)... HealthDay Reporter , WEDNESDAY, Oct. 29, ... been identified that appear linked to autism spectrum disorders, ... are on their way to discovering up to 1,000 ... Autism spectrum disorders include a range of developmental disabilities ... An estimated one in 68 U.S. children has an ...
(Date:10/30/2014)... 30, 2014 Home Care Assistance – ... of non-medical, in-home senior care, is weighing in on ... health. , The study, performed by the University of ... and 78 over a week-long period and observed how ... physical activity. By examining the structural soundness of the ...
Breaking Medicine News(10 mins):Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 2Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 3Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 4Health News:PreDiabetes Treatment Company Offers PreD Store Shoppers Supplements to Support Healthy Blood Sugar 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 3Health News:Discovery of 100-Plus Genes Tied to Autism May Improve Treatments 2Health News:Discovery of 100-Plus Genes Tied to Autism May Improve Treatments 3Health News:Home Care Assistance – Halton/Peel Region, a Top Provider of In-Home Care, Responds to Study Linking Exercise to Healthier Senior Brains 2Health News:Home Care Assistance – Halton/Peel Region, a Top Provider of In-Home Care, Responds to Study Linking Exercise to Healthier Senior Brains 3
... Treatment with the glitazone class of diabetes drugs leads ... macular edema (DME)a common complication that can lead to ... of the American Journal of Ophthalmology ( ... of about 170,000 patients with diabetes, Drs. Donald S. ...
... and David Glick highlight the serious issue of ... by F1000 Medicine Reports. , Consciousness during general ... post-operative psychological trauma and contributes towards patients, fear ... of 1000 Medicine and a leading authority on ...
... Be FeaturedSAN FRANCISCO, April 2 Over 1,000 cataract ... a San Francisco hotel Friday night. They will observe ... live from Key Whitman Eye Center in Dallas, Texas. ... approved accommodating Intraocular lens (IOL) in one patient and ...
... of Troy Limited (Nasdaq: HELE ), designer, ... household consumer products, today announced the March 31, 2009 ... global Infusium 23(R) hair care business from The Procter ... plus year heritage, has established a trusted reputation with ...
... Say They Will Not Provide Reimbursement for Xarelto ... Greater Convenience, According to a New Report from ... one of the world,s leading research and advisory ... for prevention of stroke, surveyed cardiologists estimate they ...
... is in the air, and along with it, tree, ... sufferer,s immune system a curve ball. But the April ... magazine uncovers five other surprising allergy ... need to be."When your immune system is weak, it ...
Cached Medicine News:Health News:Diabetes drug class linked to vision-threatening complication 2Health News:Surgeons to Observe and Discuss Live Eye Surgery Friday Night in San Francisco 2Health News:Surgeons to Observe and Discuss Live Eye Surgery Friday Night in San Francisco 3Health News:Helen of Troy Limited Announces Closing of Global Infusium Brand Acquisition From Procter & Gamble 2Health News:Helen of Troy Limited Announces Closing of Global Infusium Brand Acquisition From Procter & Gamble 3Health News:Helen of Troy Limited Announces Closing of Global Infusium Brand Acquisition From Procter & Gamble 4Health News:For Prevention of Stroke, Surveyed Cardiologists and PCPs Expect to Prescribe Xarelto to Approximately One-Third of Newly-Diagnosed Atrial Fibrillation Patients 2Health News:For Prevention of Stroke, Surveyed Cardiologists and PCPs Expect to Prescribe Xarelto to Approximately One-Third of Newly-Diagnosed Atrial Fibrillation Patients 3Health News:Surprising Allergy Triggers May Be Making Your Spring Sniffles Worse 2
(Date:10/30/2014)... 30, 2014 , Extensively hydrolyzed ... milk   Cow milk protein allergy (CMPA) is the leading ... Until now, it has been managed by eliminating milk ... shown that it is possible to help build of ... of children during the first year of life by ...
(Date:10/30/2014)... , Oct. 29, 2014 The global ... of test type, technology, product, and geography. The ... highest growth rate in the newborn screening market ... growth is attributed to various nations opting for ... fundamental instrument used for expanded newborn screening. Furthermore, ...
(Date:10/30/2014)... -- Hospital stretchers are apparatus used to transport ... or outside of medical infrastructure premises. In addition ... for several specialized functions such as hospital beds, ... The hospital stretchers market report studies the ... of hospital stretchers globally. The hospital stretchers market ...
Breaking Medicine Technology:Experts Present Latest Research at Allergy Day 2Experts Present Latest Research at Allergy Day 3NewBorn Screening Market by Test Type, Technology (Tandem Mass Spectrometry, Immunoassay, Enzyme Assay, Electrophoresis, Pulse Oximeter), Instrument, Accessories, Reagent & Assay Kit - Global Forecast to 2019 2NewBorn Screening Market by Test Type, Technology (Tandem Mass Spectrometry, Immunoassay, Enzyme Assay, Electrophoresis, Pulse Oximeter), Instrument, Accessories, Reagent & Assay Kit - Global Forecast to 2019 3Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 3
... of Directors of BD (Becton, Dickinson and Company) (NYSE: ... common share, payable on March 30, 2012 to holders of record ... per share. About BD ... develops, manufactures and sells medical devices, instrument systems and reagents. The ...
... Vystar Corporation (OTCBB: VYST), the exclusive creator of ... and first Chinese patent for its all-natural raw ... patents in the US and abroad that relate to Vytex ... http://photos.prnewswire.com/prnh/20100203/CL48049LOGO ) The new US patent ...
Cached Medicine Technology:Vystar® Corporation Receives its Third US Patent and First Chinese Patent for Vytex® Natural Rubber Latex 2Vystar® Corporation Receives its Third US Patent and First Chinese Patent for Vytex® Natural Rubber Latex 3
... is enzyme immunoassay kit for the ... concentration in serum. Enzyme immunoassay (EIA) ... many protein hormones in body fluids ... rapid and specific assay. This enzyme ...
SHIONORIA BNP,is a reagent used in the measurement of blood BNP. The blood BNP test allows accurate estimation of coronary functions....
... method for the semi-quantitative determination of ... human serum. The results of the ... an aid in the diagnosis of ... with elevated anti-neutrophil cytoplasmic antibodies (P-ANCA) ...
... The determination of Ang ... in monitoring the pharmacological effect ... variety of angiotensin converting enzyme ... II receptor antagonists as well ...
Medicine Products: