Navigation Links
Key to Hepatitis C May Be Two Cellular Proteins

Finding could lead to treatment with the natural compound Quercetin

FRIDAY, Jan. 8 (HealthDay News) -- Researchers have identified two cellular proteins that play an important role in hepatitis C infection, and they say the finding may point to new and less toxic treatments for the disease, which can lead to cirrhosis and liver cancer.

The conventional treatments for hepatitis C are interferon and ribavirin, which can cause major side effects and aren't effective in all patients. A new drug that targets cellular proteins rather than viral proteins would be an important advance in treatment, according to the team from the University of California at Los Angeles.

The researchers found that heat shock proteins 40 and 70 are major cellular factors in hepatitis C infection. They also discovered that a natural compound called Quercetin blocks the synthesis of these proteins and significantly inhibited viral infection in tissue culture.

Quercetin -- a plant-based bioflavonoid sometimes used as a nutritional supplement -- may have anti-inflammatory and antioxidant properties.

"This is an important finding because we can block these proteins with the idea of reducing the level of the virus in people and, ideally, completely eliminate it," study senior author Samuel French, an assistant professor of pathology, said in a UCLA news release.

The study was published in the December issue of the journal Hepatology.

A phase 1 clinical trial will be conducted at UCLA to determine if Quercetin is safe and effective in patients with type 1 hepatitis C. Only about 50 percent of patients with type 1 hepatitis C respond to treatment.

More information

The U.S. Centers for Disease Control and Prevention has more about hepatitis C.

-- Robert Preidt

SOURCE: University of California at Los Angeles, news release, Jan. 4, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Hepatitis B Foundation awards UT School of Public Health professor
2. NVHR Offers Congressman Hank Johnson Support & Encouragement as He Battles Chronic Hepatitis C Virus
3. New Hepatitis C Treatment Shows Promise
4. NVHR: New Data Finding Fewer than 1 in 5 Hepatitis C Patients Receiving Antiviral Therapy is Wake-Up Call for Washington
5. Alarming trend -- antiviral therapy to treat hepatitis C is declining in the US
6. Lloyd Wright's Alternative Medicine Has One of its Hepatitis C Viral Inhibitors Given Boost as Scripps Study Peptides Effectiveness
7. NVHR: New JAMA Article Underscores Urgent Need for Congress to Act on Viral Hepatitis Detection, Management Funding
8. Lloyd Wright's Alternative Medicine Marketing Only Blueberry Extract with 45% of Hepatitis C Inhibitor Proanthocyanidin
9. African Americans Fare Worse After Undergoing Liver Transplantation Due to Hepatitis C
10. Extending treatment after liver transplant may benefit patients with hepatitis C recurrence
11. Hepatitis B does not increase risk for pancreatic cancer
Post Your Comments:
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
Breaking Medicine Technology: