Navigation Links
Key step in the 'puncture' mechanism of cell death revealed
Date:5/12/2008

A team of medical researchers led by Dr Ruth Kluck at Melbournes Walter and Eliza Hall Institute (WEHI) has discovered a key step in the mechanism by which cells destroy themselves. In this process, called apoptosis, certain proteins cause the cell to self-destruct by puncturing its power plant. How the proteins do this has been clarified by the WEHI team. The discovery is an important step towards the identification of targets for drugs designed to regulate cell death.

Dr Kluck and her colleagues explore how cells engineer their own destruction. Properly regulated cell death is actually essential for good health. This is because our cells naturally have a limited life span. The worn out, damaged or unnecessary cells in our bodies are eliminated at the rate of one million per second and replaced by the same number of new cells for as long as we live.

If a cell fails to die when it reaches its use-by date, it may go on to multiply uncontrollably and form a cancer. Conversely, a person in whom too many cells self-destruct may develop a degenerative disease such as Alzheimers.

The cells self-destruction is driven by a protein called Bak that acts by puncturing the membrane of the mitochondria - the cells power plant. Once this power plant is wrecked, the cell is doomed.

But how does Bak do this? The crux seems to be the way Bak can bind to itself and form complexes that damage the mitochondrial membrane. Dr Kluck and colleagues have discovered that cellular distress signals cause one segment of Bak to flip out and insert neatly into a groove on another Bak molecule. The Bak doublet then forms the larger complexes that can puncture the mitochondria and provoke the cells self-destruction.

This insight into how apoptosis starts will assist in the development of drugs that can flick on the apoptosis switch to kill cancer cells more effectively. The development of drugs with the opposite effect is also important: to swit
'/>"/>

Contact: Brad Allan
allan@wehi.edu.au
61-393-452-345
Research Australia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Even Sham Acupuncture Eases Low Back Pain
2. Acupuncture does not reduce radiotherapy-induced nausea, but patients believe it does
3. Acupuncture School Gives Free Acupuncture Treatments
4. Acupuncture Cuts Need for Post-Op Painkillers
5. Acupuncture May Aid In Vitro Fertilization
6. Warning! Doctors, Insurers Hold Patients Hostage! Says Top Acupuncture Physician
7. Community Acupuncture Events Commemorate World Health Day 2008 Acupuncture Fundraiser at AOMA on Monday April 7th, 9am-4pm
8. SNAP! CRACKLE! POP! Untrained Chiropractors Doing Acupuncture!
9. Acupuncture relieves hot flushes in breast cancer patients taking tamoxifen
10. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
11. UCSD study reveals the regulatory mechanism of key enzyme
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... March 05, 2015 For PASCHA Chocolate, ... most essential ingredients, the robust flavor of the cacao ... PASCHA Chocolate is free from peanuts, nuts, dairy, ... PASCHA's offering March 6th- 8th at Expo West., ... PASCHA Chocolate has broken new ground with their New ...
(Date:3/5/2015)... INTEGRATED Healthcare Strategies, a trusted compensation ... its 2015 Children’s Hospitals Executive Compensation Survey. This ... and the survey results are exclusive to participants. ... on 60 executive and director level positions, and ... subsidiary children’s hospitals. Additionally, it provided a separate ...
(Date:3/5/2015)... Leading nutritional supplement provider Metabolic Nutrition ... and Arnold Fitness EXPO in Columbus, Ohio ... a display booth featuring free samples of its superior ... class-leading fat burner Synedrex. The company will also be ... its top-of-the-line supplements and miniature action figures of its ...
(Date:3/5/2015)... March 05, 2015 Nutrition Leaders, a ... is pleased to offer reformulated Millennium 500 Creatine to ... 500 is a German grade creatine supplement that has ... muscle recovery, and aid with overall strength gains in ... acts as a reserve energy source in the body ...
(Date:3/5/2015)... Utah (PRWEB) March 05, 2015 Jordan ... by LifeVest® as a treatment option for sudden cardiac ... monitors heart rhythm and can detect any life-threatening abnormalities. ... will alert the patient before delivering a treatment shock ... Dr. Adam Elhaddi of Jordan Valley Medical Center and ...
Breaking Medicine News(10 mins):Health News:PASCHA Allergen Free Organic Chocolate to Appear at Natural Products Expo West March 6-8, 2015 2Health News:Participation Is Now Open For INTEGRATED Healthcare Strategies 2015 Children’s Hospitals Executive Compensation Survey 2Health News:Metabolic Nutrition Exhibiting at 2015 Arnold Sports Festival and Fitness EXPO This Week 2Health News:Nutrition Leaders Offers Reformulated Millennium 500 German Grade Creatine 2Health News:New Technology Behind LifeVest® Wearable Defibrillator Saves the Life of Utah Man in Cardiac Arrest 2Health News:New Technology Behind LifeVest® Wearable Defibrillator Saves the Life of Utah Man in Cardiac Arrest 3
... highlights need for complete, unbiased information on Medicare choices. ... ... 2008 - Medicare beneficiaries trying to sort through their healthcare ... them against overly aggressive marketing tactics by some insurance companies ...
... the resulting acne scars which last long after ... distress. Now, a new study recently published ... issue), the peer-reviewed professional journal of the American ... a novel laser device combining CO2 ablation with ...
... States to End the Tobacco Settlement Spending Spree and Direct ... WASHINGTON, Nov. 19 This Sunday, November 23, ... of the largest civil settlement in United States history. The ... 46 states and the major tobacco companies that reimbursed the ...
... Project Report Makes Recommendations for System in Critical Need of ... 17 Weaknesses in food safety policy, organization and communications ... according to a report released today by the Produce Safety ... Georgetown University . , ...
... 18 Women who undergo weight-loss surgery, known as bariatric surgery, ... lower risk for pregnancy-related diabetes and high blood pressure -- ... -- than pregnant women who are obese, according to new ... are published in the November 19 issue of JAMA. ...
... Strange Appointed to CEO position and Will Join Board, Effective ... MELVILLE, N.Y., Nov. 18 /PRNewswire-FirstCall/ -- Gentiva ... provider of comprehensive home health services, announced today that its ... Effective January 1, 2009, Tony Strange will become the Company,s ...
Cached Medicine News:Health News:New Medicare Advantage Marketing Rules Help People Make Informed Choices, Allsup Says, , 2Health News:New Medicare Advantage Marketing Rules Help People Make Informed Choices, Allsup Says, , 3Health News:New Medicare Advantage Marketing Rules Help People Make Informed Choices, Allsup Says, , 4Health News:New Study Finds CO2 Ablative Fractional Resurfacing Safe And Effective For Deep Acne Scarring 2Health News:New Study Finds CO2 Ablative Fractional Resurfacing Safe And Effective For Deep Acne Scarring 3Health News:New Study Finds CO2 Ablative Fractional Resurfacing Safe And Effective For Deep Acne Scarring 4Health News:November 23 Marks Tenth Anniversary of the Largest Civil Settlement in U.S. History 2Health News:November 23 Marks Tenth Anniversary of the Largest Civil Settlement in U.S. History 3Health News:Salmonella Saintpaul Outbreak Exposes Food Safety Weaknesses 2Health News:Salmonella Saintpaul Outbreak Exposes Food Safety Weaknesses 3Health News:Some Pregnancy-Related Complications Minimized for Women Who Have Had Weight-Loss Surgery 2Health News:Some Pregnancy-Related Complications Minimized for Women Who Have Had Weight-Loss Surgery 3Health News:Gentiva Health Services Confirms Management Succession 2Health News:Gentiva Health Services Confirms Management Succession 3Health News:Gentiva Health Services Confirms Management Succession 4
(Date:3/5/2015)... , March 5, 2015  Celsion Corporation (NASDAQ: ... Company will host a conference call to discuss ... on its development programs for ThermoDox®, its proprietary ... acquired technology platforms, TheraPlas™ and TheraSilence™, in immunotherapy ... Thursday, March 12, 2015. To participate in the ...
(Date:3/5/2015)... DUBLIN , Mar. 05, 2015 Research and ... addition of the "India Pharma Outlook 2015: Accelerating ... value chain beyond Generics" report to their offering. ... from the slump in the 2013 caused by the ... 2015, growth is expected to continue to be healthy, ...
(Date:3/5/2015)... , March 5, 2015 Mallinckrodt ... global specialty biopharmaceutical company, and Ikaria, Inc. a privately-held ... into a definitive agreement under which a subsidiary of ... Dearborn -led investor group in a transaction valued at ... closing conditions, the parties expect the transaction to be ...
Breaking Medicine Technology:Celsion Corporation to Hold Year-End 2014 Financial Results Conference Call on Thursday, March 12, 2015 2India Pharma Outlook 2015: Accelerating growth to the next level - Moving up the value chain beyond Generics 2India Pharma Outlook 2015: Accelerating growth to the next level - Moving up the value chain beyond Generics 3Mallinckrodt Pharmaceuticals To Expand Hospital Growth Platform With Ikaria, Inc. Acquisition 2Mallinckrodt Pharmaceuticals To Expand Hospital Growth Platform With Ikaria, Inc. Acquisition 3Mallinckrodt Pharmaceuticals To Expand Hospital Growth Platform With Ikaria, Inc. Acquisition 4Mallinckrodt Pharmaceuticals To Expand Hospital Growth Platform With Ikaria, Inc. Acquisition 5Mallinckrodt Pharmaceuticals To Expand Hospital Growth Platform With Ikaria, Inc. Acquisition 6Mallinckrodt Pharmaceuticals To Expand Hospital Growth Platform With Ikaria, Inc. Acquisition 7Mallinckrodt Pharmaceuticals To Expand Hospital Growth Platform With Ikaria, Inc. Acquisition 8Mallinckrodt Pharmaceuticals To Expand Hospital Growth Platform With Ikaria, Inc. Acquisition 9
... Cardica, Inc. (Nasdaq: CRDC ) today announced that it will release ... Tuesday, August 17, 2010 , after the markets close. Cardica,s management will host a conference ... update on the company,s business. , , , ... , , , ...
... 4 PolyGel® is proud to announce that their ThermoActive ™ Cold & Hot ... , , ... , , ... , This is ...
Cached Medicine Technology:Cardica to Announce Fiscal 2010 Fourth Quarter and Year End Financial Results on Tuesday, August 17, 2010 2PolyGel® Receives SADMERC Approval for L-Code L3670 for ThermoActive™ Cold & Hot Mobile Compression Shoulder Orthosis 2
Inquire...
... DNA and RNA fragments from 100 bp ... a standard melting temperature multi-purpose agarose that ... Its high gel strength specification ensures that ... during Southern and Northern transfers. UltraPure™ ...
... Agarose with low electroendosmosis ... most DNA/RNA applications. If ... to be used as ... ligase and restriction endonucleases, ...
Excellent multi purpose agarose Nuclease-free, Gel point (1.5%): 36 1.5 C, EEO: 0.05-0.13 Gel strength (1%): > 1200 g/cm 2 ....
Medicine Products: