Navigation Links
Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction
Date:5/21/2009

A protein that plays a key role in tumor formation, oxygen metabolism and inflammation is involved in a pathway that extends lifespan by dietary restriction. The finding, which appears in the May 22, 2009 edition of the on-line journal PLoS Genetics, provides a new understanding of how dietary restriction contributes to longevity and cancer prevention and gives scientists new targets for developing and testing drugs that could extend the healthy years of life.

The protein is HIF-1 (hypoxia-inducible factor 1). It helps cells survive by "turning on" when oxygen levels are low. HIF-1 is also active in some forms of human cancer. HIF-1 overexpression is frequently detected in solid tumors; inhibition of HIF-1 has been proved to be an efficient way to prevent cancer growth. Now, scientists at the Buck Institute for Age Research have shown that HIF-1 is also a key player in dietary restriction. HIF-1 is involved in a molecular pathway known to regulate cell growth and metabolism in response to nutrients and growth factors.

"Previous studies on HIF-1 have mainly focused on its roles in oxygen metabolism and tumor development", said Buck faculty member Pankaj Kapahi, PhD, lead author of the study.

Kapahi says the study encourages the investigation of HIF-1 in nutrient sensing pathways. "The data in this study also points to HIF-1 as a likely target for regulating the protective effects of dietary restriction in mammals," said Kapahi.

"Dietary restriction is one of the most robust methods for extending lifespan and delaying age-related disease among various species."

Kapahi says the molecular mechanisms involved in how dietary restriction slows cancer and extends lifespan have been largely unknown. "This study gets us closer to understanding that process and gives us better targets for both designing and testing drugs which could mimic the effects of dietary restriction in humans," said Kapahi.

The r
'/>"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Protein May Hold Key to Blocking Allergy-Induced Asthma
2. Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment
3. Fear Response May Stem From Protein in Brain
4. Researchers identify key proteins needed for ovulation
5. Protein Might Mute Effects of Methamphetamine
6. Omega Protein Reports 2009 First Quarter Results
7. Protein Sciences Corporation Appoints New Board of Directors
8. Upside-down world: DNA protecting protein helps cancer drug to kill cells
9. Novel role of protein in generating amyloid-beta peptide
10. Scripps research scientists model 3D structures of proteins that control human clock
11. Key protein in cellular respiration discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 30, 2014 LTC Consumer, an independent, free ... care insurance, features an Instant Quote tool on its website, ... of LTC Consumer. Quotes are free and unlimited. , The ... only seven areas – including age, gender, and state of ... seconds (you don’t need to enter any contact information to ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Children’s Hospital ... celebrate Safety Day from 4 p.m. to 7 p.m. ... (29580 7 Mile Road, Livonia, MI 48152). The event ... bike helmets, children’s activities, music, snacks and local public ... to the Children’s Hospital of Michigan Foundation. , ...
(Date:7/30/2014)... the Monterey Bay Aquarium Research Institute (MBARI) have observed ... one half yearslonger than any other known animal. Throughout ... guarded them from predators. This amazing feat represents an ... octopuses of having plenty of time to develop within ... years with little or no food. , Every few ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 The report ... Others), by Application (Healthcare, Food, Water Treatment, Pulp & ... & ROW) - Global Trends & Forecasts to 2018". ... size of 229.54 kilotons by 2019, signifying a robust ... study. , Browse 83 market data tables and 33 ...
(Date:7/30/2014)... 2014 (HealthDay News) --,Although the vast majority of kids ... still wired very differently from children who have trouble ... processing disorders (SPD) can be overly sensitive to sound, ... skills and show a lack of concentration. Complicating ... than others. Some have trouble tolerating loud noises, like ...
Breaking Medicine News(10 mins):Health News:LTC Consumer Launches Online Tool for Getting Instant Long Term Care Insurance Estimates 2Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 2Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 3Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 4Health News:Deep-sea octopus broods eggs for over 4 years -- longer than any known animal 2Health News:Deep-sea octopus broods eggs for over 4 years -- longer than any known animal 3Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 2Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 3Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 4Health News:Different Areas of Brain Affected in Autism, Sensory Disorders 2Health News:Different Areas of Brain Affected in Autism, Sensory Disorders 3
... Study says quality years could be extended with more elder-care ... the 15 established European Union countries have a longer life ... of 50 than those in the 10 newer EU nations, ... domestic product (GDP) and spending on elderly care, the more ...
... improve the management of coronary heart disease (CHD) and ... care, according to Dr. Christopher Millett, Consultant in Public ... in the UK, and his colleagues. Their evaluation(1) of ... UK for the management of coronary heart disease, with ...
... complicated tasks and helps people recover learning they otherwise thought ... at the University of Chicago shows. , Using a test ... the first time that people who had "forgotten" how to ... those abilities were restored after a night,s sleep. , "Sleep ...
... growing database marketing agencies, announced that it received a new contract ... arthritis research in the world. , ... Columbia, Md. ... the nation,s largest and fastest growing database marketing agencies, announced that ...
... with Indoor Allergy Week to raise awareness of how ... is often very polluted with unwanted allergens and bacteria. ... it is essential to clean the air in the ... sneeze, spreading to other people in the room, This ...
... new study provides the best evidence to date that ... not only improves their health it actually increases ... University,s Comprehensive Cancer Center found that patients participating in ... breast cancer by 56 percent after an average of ...
Cached Medicine News:Health News:Established EU Countries Healthier Than Newcomers 2Health News:Money motivates doctors to reduce ethnic differences in heart disease treatments 2Health News:Sleep helps people learn complicated tasks 2Health News:Sleep helps people learn complicated tasks 3Health News:Arthritis Foundation Renews Comprehensive Marketing Contract with Merkle 2Health News:Arthritis Foundation Renews Comprehensive Marketing Contract with Merkle 3Health News:Indoor Allergy Week - Cleanaer™, the New Air Purifier that Helps Prevent Spread of the Common Cold While Removing Airborne Allergen 2Health News:Indoor Allergy Week - Cleanaer™, the New Air Purifier that Helps Prevent Spread of the Common Cold While Removing Airborne Allergen 3Health News:Indoor Allergy Week - Cleanaer™, the New Air Purifier that Helps Prevent Spread of the Common Cold While Removing Airborne Allergen 4Health News:Intervention program boosts survival in breast cancer patients 2Health News:Intervention program boosts survival in breast cancer patients 3Health News:Intervention program boosts survival in breast cancer patients 4
(Date:7/30/2014)... 2014  Today the US Surgeon General issued the most ... or sun burns stating they can lead directly to deadly ... Lushniak , says that "skin cancer is a major public ... exposure to indoor and outdoor ultraviolet light is a major ... in Boca Raton, Florida , Marta ...
(Date:7/30/2014)... 30, 2014  El Camino Hospital, a leader in ... utilizing the Leaf Patient Monitoring system to help prevent ... of patients susceptible to bed sores. The ... study of the system, which showed dramatic improvement in ... regularly is the one of the most effect ways ...
(Date:7/30/2014)... , July 30, 2014 Reportlinker.com ... available in its catalogue: mHealth and ... http://www.reportlinker.com/p0356852/mHealth-and-Home-Monitoring-–-6th-Edition.html Executive summary ... delivered, leading to better outcomes, decreased costs and ... for mHealth solutions is still in an early ...
Breaking Medicine Technology:Indoor and Outdoor Sun Tanning or Sun Burns Directly Linked to Deadly Melanoma Skin Cancer 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3mHealth and Home Monitoring - 6th Edition 2mHealth and Home Monitoring - 6th Edition 3mHealth and Home Monitoring - 6th Edition 4mHealth and Home Monitoring - 6th Edition 5mHealth and Home Monitoring - 6th Edition 6mHealth and Home Monitoring - 6th Edition 7mHealth and Home Monitoring - 6th Edition 8mHealth and Home Monitoring - 6th Edition 9mHealth and Home Monitoring - 6th Edition 10mHealth and Home Monitoring - 6th Edition 11
... VRUS ) announces that Richard E.T. Smith, ... Investor Relations and Corporate,Communications. Dr. Smith will be ... directly to Chief Financial Officer Kurt,Leutzinger., Most ... Senior Biotechnology,Analyst at JPMorgan Securities, and has been ...
... door to the understanding of and possible ... obesity, diabetes, ageing and cancer, BILLERICA, Mass., Oct. ... first ever analytical instrument for the,kinetic measurement of mitochondrial ... well microplate. For the past 75 years tools,for measuring ...
Cached Medicine Technology:Richard E.T. Smith, Ph.D. Joins Pharmasset as Vice President of Investor Relations and Corporate Communications 2Richard E.T. Smith, Ph.D. Joins Pharmasset as Vice President of Investor Relations and Corporate Communications 3Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics 2Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics 3
Grafton Trial Frame...
Classic Trial Frames UB3 that has long set the standard....
Fitment fine fits handles SF1, SF2, SF3, SF4, SF13 and SF23. Sterile blade....
... Bad-Parker blades offer the superior cutting ... technology, plus the exclusive Rib-Back design ... Brad-Parker brand producer offer the wide ... disposable scalpels. Every blade is packaged ...
Medicine Products: