Navigation Links
Key protein in cellular respiration discovered
Date:4/8/2009

[PRESS RELEASE, 8 April 2009] Many diseases derive from problems with cellular respiration, the process through which cells extract energy from nutrients. Researchers at the Swedish medical university Karolinska Institutet have now discovered a new function for a protein in the mitochondrion popularly called the cell's power station that plays a key part in cell respiration.

Every time we take a breath, our blood transports oxygen to the mitochondria, where it is used to convert the nutrients in our food to a form of energy that the body can use. Problems with this process, which is called cellular respiration, have been linked to a number of morbid conditions, from unusual genetic diseases to diabetes, cancer and Parkinson's, as well as to the normal ageing process. Despite the fact that cellular respiration is so basic, there is much scientists have yet to understand about how it is regulated.

Cellular respiration depends on proteins synthesised outside the mitochondrion and imported into it, and on proteins synthesised inside the mitochondrion from its own DNA. Researchers at Karolinska Institutet have now shown that a specific gene (Tfb1m) in the cell's nucleus codes for a protein (TFB1M) that is essential to mitochondrial protein synthesis. If TFB1M is missing, mitochondria are unable to produce any proteins at all and cellular respiration cannot take place.

"Mice completely lacking in TFB1M die early in the foetal stage as they are unable to develop cellular respiration," says Medodi Metodiev, one of the researchers involved in the study, which is presented in Cell Metabolism. "Mice without TFB1M in the heart suffer from progressive heart failure and increase mitochondrial mass, which is similar to what we find in patients with mitochondrial diseases."

The scientists believe that the study represents a breakthrough in the understanding of how mitochondrial protein synthesis is regulated, and thus increases the chances of one day finding a treatment for mitochondrial disease, something which is currently unavailable.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Protein Might Be a Troublesome Nutrient
2. Protein-Folding Problem May Help Spur Alzheimers
3. Fonterras New ClearProtein(TM) Satiety Water a First for New Zealand Market
4. Blood protein may hold key to stopping tumor growth in cancer patients
5. Bioengineered proteins: Trial confirms new way to tackle cancer
6. Siemens Highlights Cardiac-Specific C-Reactive Protein (hsCRP) Test at ACC 2009
7. Protein From Yellow Peas May Lower Blood Pressure
8. Herbalife Protein Shake Proven Effective in Clinical Study
9. Motor proteins may be vehicles for drug delivery
10. Penn researchers identify new protein important in breast cancer genes role in DNA repair
11. Researchers clone key sperm-binding proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... California (PRWEB) , ... August 22, 2017 , ... ... that the key to good health is as simple as eating healthy foods. ... food—whether it be storing fat, making insulin, or breaking apart carbohydrates—depends not only ...
(Date:8/22/2017)... ... , ... Each of the past six years, Lightning Labels has sent out a call for ... demonstrating the variety and creativity of their designs. Submissions this year were open from May ... time to announce the winners of the sixth annual Photo Contest, along with the prizes ...
(Date:8/22/2017)... ... ... Glass is new to the Texas market, but is proudly managed by widely recognized All ... models, in Grand Prairie, TX, located in the center of the DFW Metroplex, the fourth ... for the past 40 years with 32 convenient locations in Texas, Nevada and California resulting ...
(Date:8/22/2017)... ... 2017 , ... “Without Love’s Beauty and Pleasures Life Does ... faced while hoping for a better life. “Without Love’s Beauty and Pleasures Life ... spent 13 years working with deprived/neglected adolescents and almost 20 years working with ...
(Date:8/22/2017)... Raleigh, North Carolina (PRWEB) , ... August 22, ... ... senior strategic advisor. Mr. Stewart is the Founder and Managing Member for t4 ... elements that have become critical to his definition of “success”: physician leadership development, ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Aug. 7, 2017 Insightin Health, provider ... retention, and engagement, announced the selection of ... Product Development, effective as of February 2017. In this ... implementation strategy for our clients. Wood brings with ... consulting and business analytics within the healthcare industry. ...
(Date:8/7/2017)... DUBLIN , Aug. 7, 2017  Endo International ... has reached agreements to resolve virtually all known U.S. ... in discussions to resolve the known remaining U.S. claims ... installment payments beginning in the fourth quarter of 2017 ... part of its second quarter 2017 results, the Company ...
(Date:8/2/2017)... , Aug. 2, 2017 Fenita ... Who as a Pinnacle Lifetime Professional in the ... Account Manager at Turing Pharmaceuticals, AG. Her skills ... and relationship building.                ... than 25 years of experience as a highly ...
Breaking Medicine Technology: