Navigation Links
Key protein in cellular respiration discovered
Date:4/8/2009

[PRESS RELEASE, 8 April 2009] Many diseases derive from problems with cellular respiration, the process through which cells extract energy from nutrients. Researchers at the Swedish medical university Karolinska Institutet have now discovered a new function for a protein in the mitochondrion popularly called the cell's power station that plays a key part in cell respiration.

Every time we take a breath, our blood transports oxygen to the mitochondria, where it is used to convert the nutrients in our food to a form of energy that the body can use. Problems with this process, which is called cellular respiration, have been linked to a number of morbid conditions, from unusual genetic diseases to diabetes, cancer and Parkinson's, as well as to the normal ageing process. Despite the fact that cellular respiration is so basic, there is much scientists have yet to understand about how it is regulated.

Cellular respiration depends on proteins synthesised outside the mitochondrion and imported into it, and on proteins synthesised inside the mitochondrion from its own DNA. Researchers at Karolinska Institutet have now shown that a specific gene (Tfb1m) in the cell's nucleus codes for a protein (TFB1M) that is essential to mitochondrial protein synthesis. If TFB1M is missing, mitochondria are unable to produce any proteins at all and cellular respiration cannot take place.

"Mice completely lacking in TFB1M die early in the foetal stage as they are unable to develop cellular respiration," says Medodi Metodiev, one of the researchers involved in the study, which is presented in Cell Metabolism. "Mice without TFB1M in the heart suffer from progressive heart failure and increase mitochondrial mass, which is similar to what we find in patients with mitochondrial diseases."

The scientists believe that the study represents a breakthrough in the understanding of how mitochondrial protein synthesis is regulated, and thus increases the chances of one day finding a treatment for mitochondrial disease, something which is currently unavailable.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Protein Might Be a Troublesome Nutrient
2. Protein-Folding Problem May Help Spur Alzheimers
3. Fonterras New ClearProtein(TM) Satiety Water a First for New Zealand Market
4. Blood protein may hold key to stopping tumor growth in cancer patients
5. Bioengineered proteins: Trial confirms new way to tackle cancer
6. Siemens Highlights Cardiac-Specific C-Reactive Protein (hsCRP) Test at ACC 2009
7. Protein From Yellow Peas May Lower Blood Pressure
8. Herbalife Protein Shake Proven Effective in Clinical Study
9. Motor proteins may be vehicles for drug delivery
10. Penn researchers identify new protein important in breast cancer genes role in DNA repair
11. Researchers clone key sperm-binding proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... CO (PRWEB) , ... December 02, 2016 , ... Advanced ... announced it has appointed Jason Bice, CPA, MBA to serve as Advanced Inc.’s Chief ... for Advanced, Inc. , Jason brings extensive financial and operational leadership experience to ...
(Date:12/2/2016)... Raleigh, NC (PRWEB) , ... December 02, 2016 , ... ... the Open Enrollment Period (or Annual Election Period), is ending December 7th. Currently-enrolled Medicare ... plan (Part C) or prescription drug plan (Part D) need to make changes during ...
(Date:12/2/2016)... ... 02, 2016 , ... Mediaplanet’s newest campaign, “Digestive Heath,” hits ... proof that attitude and determination can combine into the most remarkable achievements. Over ... holidays. This campaign will offer patients a new-found hope, by seizing the opportunity ...
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet is ... USA Today, which covers the innovative treatments, therapeutic technologies, and revolutionized nutrition that ... “We are prolonging life 6 years in the last 3 decades,” says Dr. ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... veterinarian diagnostic imaging systems and the first company to offer robotic imaging ... Heart at their tradeshow booth # 941 for the American Association of Equine ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Dec. 2, 2016 Lianluo Smart Limited ... "the Company") which develops, markets and sells medical ... China and international markets, recently ... and Treatment New Progress Forum, co-hosted by the ... Province , Guangdong Provincial People,s Hospital and ...
(Date:12/2/2016)... Dec. 1, 2016 The concept of rare diseases ... given to this sector has been taking shape in ... the political aspects and initiatives related to orphan medicinal products ... the level of member states individually. Many member states in ... the space of orphan medicinal products, the result of which ...
(Date:12/2/2016)... Allergan plc (NYSE: AGN ), a ... previously announced Accelerated Share Repurchase (ASR) Program. Logo - ... ... previously announced, the Company entered into a variable tenor ASR ... repurchase $10 billion of its ordinary shares. Approximately 40.5 million ...
Breaking Medicine Technology: