Navigation Links
Key protein in cellular respiration discovered
Date:4/8/2009

[PRESS RELEASE, 8 April 2009] Many diseases derive from problems with cellular respiration, the process through which cells extract energy from nutrients. Researchers at the Swedish medical university Karolinska Institutet have now discovered a new function for a protein in the mitochondrion popularly called the cell's power station that plays a key part in cell respiration.

Every time we take a breath, our blood transports oxygen to the mitochondria, where it is used to convert the nutrients in our food to a form of energy that the body can use. Problems with this process, which is called cellular respiration, have been linked to a number of morbid conditions, from unusual genetic diseases to diabetes, cancer and Parkinson's, as well as to the normal ageing process. Despite the fact that cellular respiration is so basic, there is much scientists have yet to understand about how it is regulated.

Cellular respiration depends on proteins synthesised outside the mitochondrion and imported into it, and on proteins synthesised inside the mitochondrion from its own DNA. Researchers at Karolinska Institutet have now shown that a specific gene (Tfb1m) in the cell's nucleus codes for a protein (TFB1M) that is essential to mitochondrial protein synthesis. If TFB1M is missing, mitochondria are unable to produce any proteins at all and cellular respiration cannot take place.

"Mice completely lacking in TFB1M die early in the foetal stage as they are unable to develop cellular respiration," says Medodi Metodiev, one of the researchers involved in the study, which is presented in Cell Metabolism. "Mice without TFB1M in the heart suffer from progressive heart failure and increase mitochondrial mass, which is similar to what we find in patients with mitochondrial diseases."

The scientists believe that the study represents a breakthrough in the understanding of how mitochondrial protein synthesis is regulated, and thus increases the chances of one day finding a treatment for mitochondrial disease, something which is currently unavailable.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Protein Might Be a Troublesome Nutrient
2. Protein-Folding Problem May Help Spur Alzheimers
3. Fonterras New ClearProtein(TM) Satiety Water a First for New Zealand Market
4. Blood protein may hold key to stopping tumor growth in cancer patients
5. Bioengineered proteins: Trial confirms new way to tackle cancer
6. Siemens Highlights Cardiac-Specific C-Reactive Protein (hsCRP) Test at ACC 2009
7. Protein From Yellow Peas May Lower Blood Pressure
8. Herbalife Protein Shake Proven Effective in Clinical Study
9. Motor proteins may be vehicles for drug delivery
10. Penn researchers identify new protein important in breast cancer genes role in DNA repair
11. Researchers clone key sperm-binding proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... , ... “Life Under Blankets”: an entrancing story about one woman's travels ... is the creation of published author, Kimberly Mitchell, who earned her bachelor’s degree in ... to pursue a master’s degree in education in the field of curriculum and instruction. ...
(Date:1/23/2017)... ... ... Valentine’s Day is a time when many people celebrate romance and love by giving cards, ... for the ideal present, Atlanta-based Perimeter Plastic Surgery is offering a Valentine’s Day ... $200 and get $50 free. , “A lot of people just buy the more ...
(Date:1/22/2017)... (PRWEB) , ... January 22, 2017 , ... Zifam Pinnacle, ... across the world, recently met with big-name retail buyers at the January ECRM Trade ... of efficacy and uses the utmost safety standards in all of its creations to ...
(Date:1/22/2017)... ... 2017 , ... Medical lab testing through hospitals and other traditional ... test will take days to arrive to the end customer, having to travel through ... their lab tests, bypassing the cost and delay of traditional means. Now all employees ...
(Date:1/21/2017)... Boca Raton, FL (PRWEB) , ... January 21, 2017 , ... ... from Germany, announced it is bringing its product to the United States as part ... perfected over the last 25 years, Alcovit aims to reduce the productions of nasty ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... Jan. 20, 2017  Faruqi & Faruqi, LLP, a leading ... or the "Company") (NASDAQ: KMPH ) of the ... certain officers and directors and underwriters of the Company,s April ... role of lead plaintiff. The lawsuit has been ... for Johnson County on behalf of ...
(Date:1/20/2017)... , Jan. 20, 2017  Ethicon Endo-Surgery, ... Megadyne Medical Products, Inc., a privately held ... markets electrosurgical tools used in operating rooms ... of Ethicon,s* advanced energy devices with Megadyne,s ... major step forward in Ethicon,s goal to ...
(Date:1/20/2017)... Jan. 20, 2017  Palladian Health, a leading ... the launch of an opioid management program which ... opioids and helps stem the growing tide of ... to treat chronic non-cancer pain (back pain, neck ... and lack of evidence regarding long-term effectiveness. ...
Breaking Medicine Technology: