Navigation Links
Key player in detoxification pathway isolated after decades of searching
Date:11/12/2010

Chemical reactions are happening all over the place all the time--on the sun, on the Earth and in our bodies. In many cases, enzymes help make these reactions occur. One family of enzymes, called cytochrome P450s (P450), is important because they help us eliminate toxins.

We know P450s are important to life of all kinds because they have been found in animals, plants, fungi and bacteria, but they are of special interest to humans because they are responsible for metabolism of about 75 percent of known pharmaceuticals.

"The reactions that P450s perform to detoxify a compound are interesting because they activate chemical bonds that are usually not reactive. Chemically speaking, this is a very difficult thing to do in a controlled way," said Michael Green of the department of chemistry at Penn State University. Green and a former student are authors of a paper describing a breakthrough in isolation of P450 compound I, an important chemical intermediate in the process of drug metabolism. This research, supported by the National Science Foundation, appears in the November 12 issue of the journal Science.

In terms of P450s, we humans aren't all the same. One person can be susceptible to poisoning by a toxin or drug more than another based on the levels of the different P450s they have in their liver, lungs and other organs. With such obvious medical and biological importance, these enzymes have been studied in great detail for many years, but exactly how they are able to catalyze these chemical reactions remains to be determined.

At the heart of the problem is P450 compound I. It is a highly reactive chemical species produced by the P450 enzyme to help metabolize a toxin or drug. Because of this extreme reactivity, compound I turns into something else before scientists have a chance to capture it. This has remained a problem for more than 40 years, prompting some to question its very existence.

"This work confirms
'/>"/>

Contact: Lisa Van Pay
lvanpay@nsf.gov
703-292-8796
National Science Foundation
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Headgear, mouth guards have little or no impact on reducing concussions in rugby players
2. Concussion Rate in Young Hockey Players Higher Than Thought
3. Artificial Turf Helps Football Players With Agility Drills
4. NFL Players With Concussions Sidelined Longer: Study
5. Study implicates new epigenetic player in mental retardation and facial birth defects
6. MP3 Players Might Harm Hearing
7. Getting extra sleep improves the athletic performance of collegiate football players
8. Poker Players May Use Drugs to Stay Sharp at the Table
9. Study finds poker players using drugs to enhance performance
10. Human Touch Brand Ambassador and PGA Pro Tim Clark Wins First PGA TOUR Victory at PLAYERS Championship
11. Ankle Braces May Protect Girl Volleyball Players
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2015)... (PRWEB) March 06, 2015 “ Pokemini ” ... which features the latest and coolest mobile applications on the ... expert and host of NewsWatch, conducted the app review and ... game. , Over the last couple of years, mobile ... to the game. For example, Candy Crush allows users to ...
(Date:3/6/2015)... Ticket Down is a reputable source for ... the Moda Center. After being away from the touring ... no signs of letting up on his “Garth Brooks World ... wife, Trisha Yearwood, to venues around the United States. The ... acclaimed tour to the Moda Center in Portland, OR. The ...
(Date:3/6/2015)... As the Muscular Dystrophy Association continues to enhance its ... two new Scientific Program Officers, Amanda Haidet-Phillips, Ph.D and ... Pavlath, Ph.D, who joined MDA late last year as ... will lead MDA as it accelerates new front-line discovery ... of neuromuscular and motor neuron diseases. , ...
(Date:3/6/2015)... CA (PRWEB) March 06, 2015 US ... of three Maryland camps – two non-contact specialty camps ... be run by Perfect Performance Training, located at Bowie ... focus on developing position specific skills, speed and strength ... hosted at Salisbury University with Marvin Graves, former quarterback ...
(Date:3/6/2015)... California (PRWEB) March 06, 2015 Johnson ... million jury verdict on March 5, 2015 in Superior ... According to court documents, a jury of 12 awarded ... suffered from being implanted with an Ethicon TVT Abbrevo ... nine men and three women also awarded $5 million ...
Breaking Medicine News(10 mins):Health News:A Kawaii Social Game was Featured on NewsWatch Television on February 26, 2015 2Health News:Garth Brooks Tickets in Portland, OR at the Moda Center: Ticket Down Slashes Garth Brooks Ticket Prices at the Moda Center in Portland 2Health News:Garth Brooks Tickets in Portland, OR at the Moda Center: Ticket Down Slashes Garth Brooks Ticket Prices at the Moda Center in Portland 3Health News:MDA Adds Muscle Disease and ALS Leaders to Research Team 2Health News:MDA Adds Muscle Disease and ALS Leaders to Research Team 3Health News:MDA Adds Muscle Disease and ALS Leaders to Research Team 4Health News:US Sports Camps to Host Three New Football Camps in Maryland 2Health News:Johnson & Johnson Hit with $5.7 Million Verdict in Pelvic Mesh Trial Announces Matthews & Associates Law Firm 2Health News:Johnson & Johnson Hit with $5.7 Million Verdict in Pelvic Mesh Trial Announces Matthews & Associates Law Firm 3
... for first time treatment of advanced lung cancer in ... randomised study on lung cancer patients led by Dr.Alan ... at Vanderbilt-Ingram Cancer Center. ,Nearly 900 patients ... the trial. None of them had received any previous ...
... the world today, Britain had to face the embarrassment of ... week. //In a recent report by CABE it was brought ... population can be declared obese and overweight. ,The ... headquarters in London works towards improving people's quality of life ...
... to investigate a botched cataract surgery camp at the Guwahati ... ,Health Minister Himanta Biswa Sarma said the enquiry would be ... and was expected to submit the report in three months. ... hence instituted a judicial probe to fix responsibility for the ...
... Virus type C (GBV-C) protects against HIV infection is now ... Iowa// City Health Care System and the University of Iowa ... growing in cell models. ,The team found that ... NS5A greatly slows down HIV from replicating in cells grown ...
... Hospital have developed a revolutionary treatment for dementia.// ... Research Centre George Razay merely merely draining fluid from ... 5000 Tasmanians are affected by dementia and the figure ... ,20 patients, equal number of men and women ...
... In order to restrict the use animals for the ... new techniques are being developed by researchers at the ... as a financial grant. ,Gauging the carcinogenic effects ... which further necessitates the use of live animals to ...
Cached Medicine News:Health News:Judicial Probe Ordered for Botched Eye Surgery Camp 2Health News:Study IDs Protein That Inhibits HIV From Growing In Cell Cultures 2Health News:Study IDs Protein That Inhibits HIV From Growing In Cell Cultures 3Health News:Grant Encourages Drug Testing Sans Animals 2
(Date:3/5/2015)...  BioPhotas, Inc., an FDA registered medical device manufacturer ... to treat skin, muscle and joint conditions, today announced ... to provide BioPhotas, flagship product, the Celluma, ... Commenting on the alliance, Patrick ... Celluma at the Warrior Hope and Care Center had ...
(Date:3/5/2015)... -- CANTEL MEDICAL CORP. (NYSE: CMN ) will ... 2015 on Thursday, March 12 before the market opens, and ... AM ET. To participate in the conference ... the beginning of the call. If you are unable to ... from Thursday, March 12, 2015 through midnight on May 12, ...
(Date:3/5/2015)... , March 5, 2015   ndd Medical ... testing (PFT) that employs precise ultrasound technology, announced that ... event held by the San Antonio Pulmonary Fibrosis Support ... (ILD) or pulmonary fibrosis (PF), as well as those ... a footprint of a mere 12 square inches, EasyOne ...
Breaking Medicine Technology:BioPhotas, Inc. and the Semper Fi Fund Work Together to Provide Pain Relief to Injured Service Members 2BioPhotas, Inc. and the Semper Fi Fund Work Together to Provide Pain Relief to Injured Service Members 3Cantel Medical Corp. To Hold Conference Call To Discuss Results For Its Second Quarter Ended January 31, 2015 2ndd Medical Technologies' Mobile Pulmonary Function Testing Helps Combat Pulmonary Fibrosis 2ndd Medical Technologies' Mobile Pulmonary Function Testing Helps Combat Pulmonary Fibrosis 3
... 22, 2010 Pfizer Inc (NYSE: PFE ... to both the United States Food and Drug Administration ... the use of Prevnar 13®* (Pneumococcal 13-valent Conjugate Vaccine ... and older for the prevention of pneumococcal disease caused ...
... Dec. 22, 2010 Haemonetics Corporation (NYSE: ... Chief Executive Officer, will present at the J.P. Morgan ... 2011 at 1:30 pm Pacific time.  The ... at http://jpmorgan.metameetings.com/webcasts/healthcare11/directlink?ticker=HAE .  The webcast ...
Cached Medicine Technology:Pfizer Submits Applications to FDA and EMA for Use of its Pneumococcal Conjugate Vaccine, Prevnar 13®, in Adults 50 and Older 2Pfizer Submits Applications to FDA and EMA for Use of its Pneumococcal Conjugate Vaccine, Prevnar 13®, in Adults 50 and Older 3Pfizer Submits Applications to FDA and EMA for Use of its Pneumococcal Conjugate Vaccine, Prevnar 13®, in Adults 50 and Older 4Pfizer Submits Applications to FDA and EMA for Use of its Pneumococcal Conjugate Vaccine, Prevnar 13®, in Adults 50 and Older 5
The cordless Simon Dermatome with rechargeable battery is used to harvest split-thickness skin grafts and for debridement....
Forceps with round handle, straight...
Castroviejo microscopic needle holder...
Microscopic scissors, curved...
Medicine Products: