Navigation Links
Key mutations act cooperatively to fuel aggressive brain tumor
Date:3/14/2011

Mutations in three pathways important for suppressing tumors cooperate to launch glioblastoma, an aggressive brain tumor that strikes children and adults. But new research from St. Jude Children's Research Hospital scientists shows those changes alone are not sufficient to cause cancer. Tumor formation requires additional mutations, some affecting different points in the same disrupted regulatory pathways.

Researchers demonstrated that in mouse models of glioblastoma, tumors develop in several regions of the brain.

The findings, as well as the technique investigators used to generate them, are now being used as a possible tool for understanding patients' responses to investigational therapies that target some of the same pathways. The research appears in the March 15 edition of the scientific journal Cancer Cell.

The work builds on previous studies that linked glioblastoma to disruptions in the RB1, p53 and Pten pathways, each of which has a key role in preventing tumor formation. For this study, St. Jude investigators developed a novel system that allowed them to delete the genes, either singly or in various combinations, for which the pathways are named. Researchers then tracked the impact of those deletions on the brains of adult mice.

Gliomas are the most common primary malignant brain tumor, representing more than half of the 18,000 malignant brain tumors diagnosed annually in the U.S. These tumors remain the second most common cause of cancer death among individuals ages 15 through 44. Survival is less than 10 percent for patients with the most aggressive gliomas subtype, glioblastoma.

"In this study, we set out to look at the contribution of each of these pathways and how they cooperate to generate gliomas," said Suzanne Baker, Ph.D., a member of the St. Jude Department of Developmental Neurobiology and the paper's senior author. "When you analyze a human tumor, you see all of the accumulated mutatio
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
2. Study shows that mutations in 1 gene cause many cancers
3. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
4. Gene Mutations Up Risk for Cancer in Opposite Breast
5. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
6. Single Lung Tumor Contains 50,000 Mutations
7. Gene Mutations Offer Clues to Autoimmune Disorders
8. Individual mutations are very slow to promote tumor growth
9. Study finds women with triple negative breast cancer and BRCA mutations have lower risk of recurrence
10. Gene Mutations May Blunt Plavixs Effectiveness, Study Finds
11. Unexpectedly small effects of mutations in bacteria bring new perspectives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... September 20, 2014 Ticket Down ... tickets . This popular ticket exchange is offering their ... , The 2015 schedule of tours is beginning to fill ... announced their plans to hit the road, including 21-year-old pop ... announced the “Honeymoon Tour,” which will take her to 25 ...
(Date:9/20/2014)... 20, 2014 Lifeinsurancequoteterm.net has released ... no medical exam life insurance plan provides for vulnerable ... family members should be a top priority for every ... insurance without taking medical examinations and visiting a doctor. ... medical examinations will provide coverage up to $300,000, but ...
(Date:9/20/2014)... 2014 New PharmaPoint Drug Evaluation ... to 2023?. The asthma market saw very slow ... become saturated with relatively efficacious standard therapies, such ... corticosteroids and long-acting beta-agonists (ICS/LABAs), and leukotriene modifiers, ... However, the launch of seven novel targeted biologic ...
(Date:9/20/2014)... September 20, 2014 Traditionally dentists have advised ... South Charlotte Dentistry is re-visiting that advice and ... effects that coffee and wine have on oral health. “There’s ... determined that coffee may be beneficial in protecting against gum ... , The study on coffee was from the September ...
(Date:9/20/2014)... September 20, 2014 QueenBeeTickets.com is ready ... star’s tour performances. She will visit many cities in ... until the 16th of April. , Click Here ... Tour tickets at QueenBeeTickets.com. , The star’s fans are ... see their favorite young singer in a live performance. ...
Breaking Medicine News(10 mins):Health News:Ariana Grande Tickets in Phoenix, Los Angeles, Anaheim, San Jose, Seattle, and Vancouver Go on Sale Today 2Health News:Ariana Grande Tickets in Phoenix, Los Angeles, Anaheim, San Jose, Seattle, and Vancouver Go on Sale Today 3Health News:No Medical Exam Life Insurance Provides Financial Protection for Families 2Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 2Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 3Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 4Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 3Health News:Discount Ariana Grande Tickets: QueenBeeTickets.com Delights Fans with Discount Concert Tickets for Ariana Grande’s 2015 Honeymoon Tour 2
... Japan, May 8 Dr. Hidenari Tanaka, president ... of the Japan Contact Lens Association, was appointed ... the government of the Republic of Singapore. The ... Consulate-General will be located at Menicon,s corporate headquarters ...
... HealthSystem Consortium (UHC) today announced that it has awarded ... in Gaithersburg, Md, for food and nutrition services. The ... effective on May 1, 2009. Sodexo is a leading ... services to hospital patients, staff, and visitors. Services are ...
... Reform Work for ChildrenSTANFORD, Calif., May 7 Lucile ... the National Association of Children,s Hospitals (N.A.C.H.) as it ... Congress and the Obama Administration to make health care ... extraordinarily proud to be taking part in Speak Now ...
... Inc., (Nasdaq: MEDQ ) a leading provider of ... workflow, today announced its unaudited operating results for its first ... of 2009 was $6.9 million, an increase of $11.3 million ... $4.4 million was reported. Earnings per share for the first ...
... Va., May 7 Trey Anastasio, lead singer of the ... Hill on Wednesday, May 6, to participate in a day-long ... joined the National Association of Drug Court Professionals (NADCP) in ... in need. Mr. Anastasio recognized over fifteen members of Congress ...
... is a statement from Georges C. Benjamin, MD, FACP, ... Association:"The American Public Health Association (APHA) joins other leading ... in President Obama,s FY 2010 budget."Of particular note is ... be used to finance health reform and ensure that ...
Cached Medicine News:Health News:Dr. Tanaka Appointed as Honorary Consul-General by Republic of Singapore 2Health News:University HealthSystem Consortium Selects Sodexo to Provide Food and Nutrition Services 2Health News:Lucile Packard Children's Hospital at Stanford to Raise Its Voice for Kids in Health Care Reform Debate 2Health News:Lucile Packard Children's Hospital at Stanford to Raise Its Voice for Kids in Health Care Reform Debate 3Health News:MedQuist Reports First Quarter 2009 Results 2Health News:MedQuist Reports First Quarter 2009 Results 3Health News:MedQuist Reports First Quarter 2009 Results 4Health News:MedQuist Reports First Quarter 2009 Results 5Health News:MedQuist Reports First Quarter 2009 Results 6Health News:MedQuist Reports First Quarter 2009 Results 7Health News:MedQuist Reports First Quarter 2009 Results 8Health News:MedQuist Reports First Quarter 2009 Results 9Health News:Phish Frontman Trey Anastasio Visits Capitol Hill to Support Drug Courts and Calls on Congress to Put a Drug Court Within Reach of Every American in Need 2Health News:Phish Frontman Trey Anastasio Visits Capitol Hill to Support Drug Courts and Calls on Congress to Put a Drug Court Within Reach of Every American in Need 3Health News:APHA Applauds Health Reform Fund and Other Health Investments in Budget 2
(Date:9/19/2014)... , Sept. 19, 2014 /PRNewswire-iReach/ -- ... Oxybutynin Hydrochloride Industry, 2009-2019 is a professional ... Chinese Oxybutynin Hydrochloride industry. The report firstly ... including its classification, application and manufacturing technology. ... top manufacturers of Oxybutynin Hydrochloride listing their ...
(Date:9/19/2014)... , Sept. 19, 2014 /PRNewswire-iReach/ -- ... to 2020″, provides key market data ... devices market. The report provides value, ... volume (in units) within market categories ... Sigmoidoscopes, Esophagoscopes & Gastroscopes, Duodenoscopes, Laparoscopes, ...
(Date:9/19/2014)... 2014 Kiromic, LLC, a Lubbock ... Hance , the former chancellor of Texas Tech University, to ... in July 2014, after raising $1.2 billion for the university. ... Hance , the most successful chancellor in the history of ... as an investor, but also as our new vice chairman ...
Breaking Medicine Technology:Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 4United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 5Former Texas Tech Chancellor Named New Vice Chairman of the Board of Kiromic, LLC 2
Serrated handle with 7 mm tying platform and polished finish. Teeth: 0.25 mm, 2 x 2 set at 45 degrees....
5 mm tying platform, serrated cross action handle with polished finish. Teeth: 0.10 mm, 1 x 2 set at 90 degrees....
5 mm tying platform, serrated cross action handle with polished finish. Teeth: 0.10 mm, 1 x 2 set at 45 degrees....
6 mm tying platform. Round knurled handle with polished finish. Teeth: 0.3 mm, 1 x 2. Orientation: Left hand....
Medicine Products: