Navigation Links
Key growth factor identified in T cell leukemia
Date:8/1/2011

Blocking a growth factor receptor cripples cancer growth in a form of T cell leukemia, according to a study published online on August 1 in the Journal of Experimental Medicine (www.jem.org).

Approximately half of the cases of T cell acute lymphoblastic leukemia (T-ALL) carry genetic mutations in a cellular signaling pathway called Notch, which result in aberrant activation of the cell. A study by Andrew Weng and colleagues at the British Columbia Cancer Agency now shows that activation of the Notch pathway promotes the expression of a receptor for insulin growth factor (IGF-1), which drives the growth and survival of the cancer cells.

Cancer cells with an activated Notch pathway but lacking the IGF-1 receptor had reduced growth in mice, and blocking the receptor with drugs improved their survival. Simply reducing the amount of receptor resulted in the loss of cancer stem cellsthe cells responsible for originating and perpetuating the disease. Human T-ALL cells were also found to express IGF-1 receptor, suggesting that blocking the receptor in combination with standard treatment may reduce the risk of disease relapse.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related medicine news :

1. Education -- a key determinant of population growth and human well-being
2. Progesterone inhibits growth of neuroblastoma cancer cells
3. Self-referral: A significant factor in imaging growth
4. Hereditary colon cancer syndrome marked by abnormally dense blood vessel growth in mouth
5. Slow growth of childhood brain tumors linked to genetic process seen in skin moles
6. Scientists image beginning stages of ovarian cancer growth with time-lapse technique
7. Cancer cells accelerate aging and inflammation in the body to drive tumor growth
8. Common transplant drug inhibits breast cancer growth, UNC laboratory study shows
9. Enzyme may drive breast cancer growth
10. Artificial tissue promotes skin growth in wounds
11. Obstructive sleep apnea linked to cancer growth in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... ARLINGTON, VA (PRWEB) , ... February 26, 2017 , ... ... Medicaid Managed Care Summit, February 27-28 at the Sheraton Pentagon City Hotel in Arlington, ... work with PerformCARE to use behavioral health analytics to improve Medicaid population health management. ...
(Date:2/25/2017)... ... , ... FCPX users now have the ability to sharpen a desired color ... users have total control over sharpening amount, sharpening radius, threshold, horizontal sharpening, vertical sharpening, ... users can visually see the color range effected with ease all within Final ...
(Date:2/24/2017)... ... , ... Only two months after the official release of The Private Collection ... XO Private has initiated a second print-run of its lavish luxury travel coffee table ... when open, weighs in at more than six kilos, retails at EUR 1,000 per ...
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... ... provost of Liberty University, has officially announced the appointment of Peter A. Bell, ... College of Osteopathic Medicine (LUCOM), beginning April 10. Dr. Bell comes to ...
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... ... and hearing disabilities, it is so critically important that we all are aware ... That is why Mediaplanet is proud to announce the launch of its newest ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... , Feb. 24, 2017 Research and Markets ... & Trends - Industry Forecast to 2025" report to their offering. ... The Global Empty Capsules ... the next decade to reach approximately $2.9 billion by 2025. ... the given segments on global as well as regional levels presented in ...
(Date:2/24/2017)... , Feb. 24, 2017  In conjunction with ... 2016 financial results press release, you are invited to ... live over the internet on Tuesday, March 14, 2017 ... A live audio webcast of the presentation ... www.durect.com and clicking "Investor Relations."  If you are ...
(Date:2/24/2017)... 2017 Report analyzes the worldwide markets for Endodontic ... for the US, Canada , ... Asia-Pacific , Latin America , and ... the period 2015 through 2022. Also, a six-year historic analysis ... derived from primary and secondary research. Company profiles are primarily ...
Breaking Medicine Technology: