Navigation Links
Key function of mutation in hereditary breast and ovarian cancer gene discovered
Date:9/1/2011

Richmond, Va. (September 1, 2011) It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers at Virginia Commonwealth University Massey Cancer Center have shown that certain BRCA1 mutations result in excessive, uncontrolled DNA repair, which challenges the prior assumption that mutations in BRCA1 only contribute to breast cancer through a reduction in function.

Recently published in the journal Aging, the study led by Kristoffer Valerie, Ph.D., discovered that certain BRCA1 mutations affecting the BRCA1 C-terminal (BRCT) binding site resulted in excessive DNA repair, or hyper-recombination, which may contribute to the development of breast and ovarian cancers. The BRCT domain is a protein binding site typically found on DNA repair proteins like BRCA1 that are responsible for maintaining genomic stability and facilitating DNA repair. This study has implications for the treatment, diagnosis and development of therapies for patients with breast and ovarian cancer.

"Our findings suggest that caution should be exercised when targeting BRCA1 for breast and ovarian cancer therapies," says Valerie, co-leader of the Radiation Biology and Oncology program and a professor in the Department of Radiation Oncology at VCU Massey Cancer Center. "We need to better understand the biological mechanisms that lead to the development of breast and ovarian cancer before we attempt to attack it through targeted therapies aimed at causing DNA damage."

When DNA damage occurs, various forms of BASC (BRCA1-associated genome surveillance complex) bind to the BRCT domain on BRCA1. BASC is a protein complex that in part binds to the BRCT domain and serves as a "docking site" for other proteins and enzymes to come in, effectively repair the DNA damage and leave when repair is completed. Howeve
'/>"/>

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Common Heart Dysfunction Can Help Bring on Heart Failure
2. When erectile dysfunction isnt whole story
3. New piece to the puzzle of brain function
4. Medical Tattoo Tracks Body Functions
5. With Age, Focus on Body Shifts From Appearance to Function
6. Neighborhood status influences older womens cognitive function, study finds
7. Antioxidants of growing interest to address infertility, erectile dysfunction
8. Drug improves brain function in condition that leads to Alzheimers
9. Exposure to Common Chemicals May Affect Thyroid Function
10. Stem cell treatment may restore cognitive function in patients with brain cancer
11. New brain research suggests eating disorders impact brain function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... 01, 2015 , ... Éminence Organic Skin Care is adding ... Peels. This revolutionary collection of natural peel solutions complements the existing routine for ... Formulated with alpha hydroxy acids and natural active ingredients, these results-oriented peels deliver ...
(Date:9/1/2015)... , ... September 01, 2015 , ... Dr. Trace Curry ... JourneyLite of Cincinnati. In the last month the FDA has approved two intra-gastric ... ™. These procedures represent the first incisionless, reversible, weight loss procedures available to ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... archiving solution integrated with Alfresco‘s enterprise content management system. PRO Archiver for ... millions of dollars in printing costs by digitizing vast amounts of customer ...
(Date:9/1/2015)... Pasadena, California (PRWEB) , ... September 01, 2015 ... ... Anna Arrowsmith interviewed dating men and pick-up artists about their experiences of female ... alongside men’s bodily concerns, including penis issues, as well as their relationships with ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... Anthony J. ... the Super Lawyers 2015 for his third consecutive year in a row. Through ... accomplishments of helping people. , Born in Niagara Falls, New York, Tantillo is a ...
Breaking Medicine News(10 mins):Health News:Éminence Organic Skin Care Introduces Results-Oriented Exfoliating Peels for Every Skin Type 2Health News:Éminence Organic Skin Care Introduces Results-Oriented Exfoliating Peels for Every Skin Type 3Health News:Dr. Trace Curry Performs First ORBERA™ Intra-gastric Balloon in Ohio at JourneyLite, a New Incisionless Option For The Treatment of Obesity 2Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 2Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 3Health News:Female Porn Director Explains Male Insecurities about Women in a New Book 2
... test is all it could take to tell if you ... team of international scientists have discovered more than 10 types ... of a person who recently suffered a stroke or heart ... international collaboration led by Nanyang Technological University (NTU),s lead scientist, ...
... Virginia G. Piper Cancer Center Clinical Trials are the first ... determine the safety, tolerability and preliminary activity of an investigational ... form of lung cancer, as well as other forms of ... patient on the study was administered the first dose of ...
... in infant death are significantly more likely to have ... September) in BJOG: An International Journal of Obstetrics ... rates of stillbirth in subsequent pregnancy, the study by ... the University of Rochester found. Infant mortality ...
... News) -- People who are depressed are at greater risk ... researchers pointed out that the findings could have a significant ... of death and permanent disability. Researchers analyzed 28 previous ... 8,478 stroke cases. The investigators found that depression was associated ...
... Scientists proposing to develop vaccines against methamphetamine and nicotine ... for Innovative Medication Development Research. The two scientists, ... and Dr. Peter Burkhard, of the University of Connecticut, ... years to support their research, according to the National ...
... , TUESDAY, Sept. 20 (HealthDay News) -- Black women who develop ... second cancer in the other breast, and those who are diagnosed ... cancer of a more aggressive form, new research indicates. ... to be more aggressive, more likely to be estrogen-receptor negative and ...
Cached Medicine News:Health News:Novel research set to pinpoint risk of heart attacks and strokes 2Health News:Novel research set to pinpoint risk of heart attacks and strokes 3Health News:TGen-Virginia G. Piper Cancer Center launches clinical trial for drug to treat lung cancer 2Health News:Infant mortality linked to subsequent risk of stillbirth finds new US study 2Health News:Infant mortality linked to subsequent risk of stillbirth finds new US study 3Health News:Depression Tied to Higher Risk for Stroke 2Health News:NIDA Avant-Garde-Medications Development Award winners announced 2Health News:Higher Risk of Second Breast Cancer Seen in Black Women 2
(Date:8/31/2015)... Pa. , Aug. 31, 2015 The ... reversed statewide since Pennsylvania State ... life-saving drug kits, naloxone. Heroin and opioid ... Pennsylvania , killing more individuals than ... approximately 2,400 Pennsylvanians died from a drug overdose. ...
(Date:8/31/2015)... YORK , Aug. 31, 2015  Dipexium Pharmaceuticals, ... focused on the development and commercialization of Locilex® (pexiganan ... today announced plans to participate in four investor conferences ... 2, 2015 at the Sidoti & Company, LLC Emerging ... . David P. Luci , President & ...
(Date:8/31/2015)... 31, 2015 BioLight ... BLGTY) ("BioLight" or the "Company"), a firm that ... ophthalmology and cancer diagnostics, today announced that its ... identified several new genetic markers with high potential ... treated with bisphosphonate drugs and was able to ...
Breaking Medicine Technology:Departments of Drug & Alcohol Programs and Health Announce Report 289 Pennsylvanian Lives Saved by Naloxone 2Departments of Drug & Alcohol Programs and Health Announce Report 289 Pennsylvanian Lives Saved by Naloxone 3Dipexium Pharmaceuticals Announces Participation in Four Investor Conferences in September 2Dipexium Pharmaceuticals Announces Participation in Four Investor Conferences in September 3BioLight Reports Positive Clinical Study Results for Identifying New Genetic Markers to Predict Risk of Developing BRONJ 2BioLight Reports Positive Clinical Study Results for Identifying New Genetic Markers to Predict Risk of Developing BRONJ 3BioLight Reports Positive Clinical Study Results for Identifying New Genetic Markers to Predict Risk of Developing BRONJ 4
... BOSTON, April 4, 2011 PAREXEL International Corporation (NASDAQ: ... financial results on Monday, May 2, 2011 after the close ... PAREXEL,s website at www.PAREXEL.com and on the PR ... host a conference call and live webcast at 10:00 a.m. ...
... CITY, Calif., April 4, 2011 Sofie Biosciences, a ... launch of GENISYS4, their new benchtop small animal PET ... Cancer Research Annual Meeting, this compact, preclinical multimodality PET ... and measure the biology of disease and therapeutic response ...
Cached Medicine Technology:PAREXEL Announces Date of Third Quarter Fiscal Year 2011 Earnings Release and Conference Call 2Sofie Biosciences Launches a High Performance, Benchtop Preclinical PET System Using New Generation Detector Technology 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: