Navigation Links
Key found to breakthrough drug for clot victims
Date:3/10/2008

PORTLAND, Ore. A team of researchers at Oregon Health & Science University and Washington University in St. Louis have described for the first time the mechanism that gives a mutant enzyme molecule that they have engineered and patented the potential to become a breakthrough drug for treating heart attacks and strokes.

The team described how their genetically modified enzyme, called WE-thrombin, functions as a potent clot busting agent while retaining little of the power that thrombin, its non-engineered parent, has to cause the opposite result, a cascade of clot building. They did so in a paper published recently in Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB), a peer-reviewed journal of the American Heart Association. An editorial commentary in ATVB hailed this breakthrough as a significant advance in understanding the functions and antithrombotic potential of (WE thrombin) in particular, and the approach of using engineered human proteins more broadly

The successful development of WE-thrombin would be a major medical breakthrough in antithrombotic therapy, ultimately saving thousands of lives worldwide each year, said the lead investigator Andrs Gruber, M.D., Ph.D., associate professor of medicine in the division of hematology and medical oncology, OHSU School of Medicine.

Thrombin is an enzyme that, paradoxically, has the capacity both to promote and prevent blood clotting. Balancing the two depends on a highly complex system of positive and negative feedback loops. Normal blood clotting is vital to minimize bleeding in the event of an injury. Excessive clotting can lead to thrombosis, the blockage of a blood vessel.

Heart attacks and strokes most often the result of blood clots remain two of the three leading causes of death and severe disability in the United States. The toll from these diseases persists at high levels in part because the drugs now relied on to stop or break up clots such as heparin or TPA, tis
'/>"/>

Contact: Harry Lenhart
lenharth@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Lupus Foundation to Host Community Outreach Initiatives
2. National Patient Safety Foundation Proposes Universal Patient Compact
3. United Mitochondrial Disease Foundation Statement on Vaccines, Autism and Mitochondrial Disease
4. Founding Father of Modern Cosmetic Dermatology Seeks to Warn Public of Misrepresented Data and Inappropriate Use of Botox
5. Lupus Foundation of America Webchat to Discuss Kidney Disease in Lupus
6. Zounds Hearing Enters Moorestown and Announces $225,000 Hearing Partnership With Twilight Wish Foundation
7. Whole Planet Foundation(TM) (a Whole Foods Market Foundation) and Nobel Peace Prize Winner Dr. Muhammad Yunus Partner With Natural Foods Vendors, Pledging Over $1 Million to Help Combat Poverty
8. Childrens Burn Foundations Benefit Raises More Than $875,000 for Burn Survivors and Prevention
9. Cultivating the Smart Patient: Author and RealAge Founder Michael F. Roizen, MD to Present Keynote at URAC Conference
10. White Hat Brands, Juvenile Diabetes Research Foundation Offer the Juice on New Partnership
11. Inaugural Bowen Foundation Run/Walk to Fight Autism in Maryland Set for Saturday, March 29
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... It can be ... against dribbled urine and sweat. "In order to prevent these problems, I conceived ... ACCESS DRYNESS ENHANCED MEN'S UNDERGARMENT provides optimal support for a male’s crotch. It ...
(Date:8/29/2015)... ... August 29, 2015 , ... ProDrop Particles includes over 40 particle ... 15 seconds of unique footage that users can shrink and stretch in the Final ... more. Users can customize color, brightness, scale, speed, range, and flare attributes with intuitive ...
(Date:8/28/2015)... ... ... Rio Salado College joined nine educational institutions in Washington D.C., July ... - Next Generation Learning Challenges 2015 Breakthrough Models Incubator funded by the Bill ... hosted by EDUCAUSE and NGLC, which is designed to bring leadership teams of ...
(Date:8/28/2015)... ... August 28, 2015 , ... An article published August ... Paul LaRocco has gone through to open a pizzeria in Westchester. Mr. LaRocco was ... to take several months, but the current process, having already gone on for over ...
(Date:8/28/2015)... Hanover, MA (PRWEB) , ... August 28, 2015 , ... ... benefitting the renowned Brain Aneurysm Foundation has added yet another accolade to its ... Chicago, Rahm Emanuel. , “With the help of the medical community and ...
Breaking Medicine News(10 mins):Health News:Modified Men’s Underwear Promote More Comfort and Hygiene - Designed by InventHelp Client (LGI-1968) 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 2Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 3Health News:Rio Salado College Joins 9 Educational Leaders to Reinvent Higher Learning 4Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3
... In 2008, The Larry King Cardiac,Foundation, a nonprofit organization ... health insurance, increased the number of men and,women served ... expand its,national network of partner hospitals. , ... medical procedures,the Foundation helped save the lives of 313 ...
... this breakthrough alternative to surgery and prescription drugsSANTA FE, ... 15 million people currently suffer from TMJ, the grueling ... These numbers may explain the overwhelming response to a ... woman who successfully treated her TMJ with Natural TMJ ...
... a conference call Thursday, Feb. 5, at 10 a.m. Eastern Time to discuss results from its first ... the earnings call. , What: ... 10:00 a.m. ET, Thursday, Feb. 5, 2009, ... Dial-in conference call, ...
... to match desired tone of company,s culture , ... ... -- The Furniture Source, provider of new and used office ... companies inspire the right ideas in their employees by providing ...
... This Week,s Keystone Symposium - Obesity: Novel Aspects of ... Interleukin Genetics, Inc. (NYSE Alternext US: ILI) announced ... on the role genetics play in an individual,s ability ... calorie-restricted diet, during tomorrow,s Keystone Symposium titled, "Obesity: Novel ...
... AutoGenomics, a leader in providing automated molecular testing ... was used in a study to demonstrate the ... antiplatelet agent, Plavix. Plavix, commonly ... in the treatment for coronary artery disease, peripheral ...
Cached Medicine News:Health News:2008 a Year of Growth and Unprecedented Service for The Larry King Cardiac Foundation 2Health News:2008 a Year of Growth and Unprecedented Service for The Larry King Cardiac Foundation 3Health News:Natural TMJ Relief(R) Gains Momentum in the Medical Marketplace 2Health News:MedCath Corporation to Hold Conference Call on First Quarter Results 2Health News:Used Conference Room Furniture from The Furniture Source Helps Inspire Strategic Business Decisions 2Health News:Interleukin Genetics to Present Data Highlighting Link Between Inflammatory Gene Variations and Less Effective Weightloss 2Health News:Interleukin Genetics to Present Data Highlighting Link Between Inflammatory Gene Variations and Less Effective Weightloss 3Health News:AutoGenomics CYP 2C19 Test Used in Study to Personalize Clopidogrel (Plavix) Dosing in Patients 2
(Date:8/28/2015)... -- Perrigo Company plc ("Perrigo") (NYSE: PRGO ; TASE) ... leading OTC brands from GSK in an all cash ... clear demonstration of Perrigo,s unique ability to maximize brand ... 36 countries.  Perrigo Chairman, President and ... excited to complete this transaction, which clearly demonstrates our ...
(Date:8/28/2015)... PITTSBURGH , Aug. 28, 2015 ... announced that its shareholders have approved Mylan,s proposed ... ; TASE) and the related issuance of Mylan ... general meeting of shareholders held today. The transaction ... the extraordinary general meeting. In addition, the transaction ...
(Date:8/28/2015)... 28, 2015 The report "Eubiotics Market by Type ... Ruminant, and Aquaculture), & by Region ( North America ... , and Rest of the World) - Global Trends ... for Eubiotics was valued at USD 4.62 Billion in 2014 ... at a CAGR of 7.4% from 2015 to 2020. ...
Breaking Medicine Technology:Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 4Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 2Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 3Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 4Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 5Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 6Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 7Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 8Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 9Eubiotics Market Worth 7.05 Billion USD by 2020 2Eubiotics Market Worth 7.05 Billion USD by 2020 3Eubiotics Market Worth 7.05 Billion USD by 2020 4Eubiotics Market Worth 7.05 Billion USD by 2020 5
... trocars consist of three separate components: an exchange ... and a transparent trocar sleeve. The exchange rod ... ends, 35cm long. The dilating obturator is tapered ... dilate an opening created by the 10/11mm or ...
... is a full-featured trocar that consists of a ... is designed to cover the pyramidal tip to ... the abdominal or thoracic cavity has been entered. ... to insert is not required. , ,The ...
... At Ethicon Endo-Surgery, we believe that ... of any procedure, facilitating instrument precision and ... three years designing a trocar that meets ... ,Introducing the ENDOPATH® Xcel™ - The ...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Medicine Products: