Navigation Links
Key factor in brain development revealed, offers insight into disorder
Date:3/26/2008

or known as dynein to the surface of both sides of the cell membrane. There, dynein takes a fixed position and, like a molecular hook, pulls the microtubules that emanate from the middle of the cell toward it.

Just like a pulley, dynein draws the microtubules through it and that, in turn, rotates the spindle, suggests Wynshaw-Boris.

Loss of Lis1, results in reduced and weakened microtubules and an inability of the mitotic spindle to rotate the microtubules properly in the apical-basal axis.

Of note, while loss of Lis1 is catastrophic in neuroepithelial stem cells, it is not so in radial glial progenitor cells. The reason is not entirely clear, says Wynshaw-Boris, but the scientists hypothesize that neuroepithelial stem cells require a greater tightness of control of the plane of cell division. In support of this notion, while neuroepithelial stem cells appear to always divide symmetrically, radial glial progenitor cells often divide asymmetrically to produce one daughter cell (radial glial progenitor cell) and one newborn nerve cell.

The study sheds some light on the differences in the regulation of symmetric and asymmetric divisions in neuroepithelial stem cells and radial glial progenitor cells, says Wynshaw-Boris.

More broadly, he says, the findings suggest that neural migration birth defects, such as lissencephaly, may be caused by defects in other processes, as well, including proliferation, division and, in this case stem cell division. It gives insight, he says, into these rare diseases and whats important for normal brain development.


'/>"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Study, meta-analysis examine factors associated with death from heatstroke
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
5. PA Health Department Survey Shows Impact of Income, Gender, Other Factors on Health and Access to Health Care
6. Researchers genetically engineer micro-organisms into tiny factories
7. Study Downgrades Gene as Heart Risk Factor
8. Severe heart defect likely caused by genetic factors
9. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
10. Aggressively Treating Cardiac Risk Factors May Reverse Ischemia
11. New peptide communication factor enabling bacteria to talk to each other discovered
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Key factor in brain development revealed, offers insight into disorder
(Date:9/1/2015)... ... 02, 2015 , ... The Journal of Pain Research has published ... ”. , As corresponding author Mr Christopher Malone says “Migraine headache is a painful ... endeavoured to better understand how migraine headaches impact the lives of migraineurs. We asked ...
(Date:9/1/2015)... ... September 01, 2015 , ... Stress comes in ... from everyday life changes can lead to very serious, life-altering events. Fortunately nature ... with stress. Herbal supplement manufacturer MediHerb has coupled therapeutic doses of ...
(Date:9/1/2015)... ... , ... Georgia State University and its partners have introduced ... sexual assaults on their campuses. , The free, evidence-based survey was developed by ... and student affairs professionals responding to calls by the Obama Administration to strengthen ...
(Date:9/1/2015)... , ... September 01, 2015 , ... ... that creates negative pressure inside a wound to remove exudates, fluid, and infectious ... devices (comprising portable devices, stand-alone devices, disposable devices, and canisters, etc.) is projected ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... The Jerry ... at The ACE Club and Green Valley Country Club in Lafayette Hill, PA. Over ... raised more than $13.5 million for programs and services designed to support patients and ...
Breaking Medicine News(10 mins):Health News:Migraine, treatment, comorbidities, and quality of life published by Dove Medical Press 2Health News:MediHerb Launches New Herbal Supplement to Help with the Challenges of Everyday Life 2Health News:MediHerb Launches New Herbal Supplement to Help with the Challenges of Everyday Life 3Health News:Georgia State, Partners Introduce Climate Survey to Aid in Preventing Campus Sexual Assaults 2Health News:World Negative Pressure Wound Therapy Market Assessed by GlobalData in In-demand Report Published at MarketPublishers.com 2Health News:World Negative Pressure Wound Therapy Market Assessed by GlobalData in In-demand Report Published at MarketPublishers.com 3Health News:The 26th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 2Health News:The 26th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 3
... of a recent study researchers say cholesterol may be actually ... , however researchers also say that too much of it ... the arteries, where it builds up as plaque and can ... called ACAT2 may be to blame for the build-up. ACAT2 ...
... Medical Association, a recent study had shown that //low-grade prostate ... 20 years. ,Scientists have treated men in the age ... prostate cancer conservatively. They have used either observation or immediate ... a mean period of 24 years. , ,The results ...
... a new breed of mice that can reduce free radicals ... ,The reactive oxygen of the free radicals are known to ... and even death. The new research may be the first ... ageing. ,The new mice created by the research ...
... depression may be two separate conditions that frequently co-exist. ... say that it is essential to treat depression and ... ,The researchers had studied 33 women and 20 men ... extensive tenderness to touch along with intense pain and ...
... of Cincinnati College of Medicine had been successful in ... ,Their research had led to finding of neutrophil gelatinase-associated ... renal injury after the patient had a cardiopulmonary bypass ... undergone cardiopulmonary bypass, 20 children had developed acute renal ...
... Men who have fought wars are more likely to have cardiovascular ... wars are more likely to be heavy drinkers of alcohol, heavy ... veterans are four times likely to be taken to drinking more ... and 1.6 times more likely to be heavy smokers than non-smokers. ...
Cached Medicine News:
(Date:9/1/2015)... Sept. 1, 2015  AccuTec Blades, Inc. today announced ... Blades division.  EPC announced in May 2015 its intent ... Verona, Virginia and Obregon, Mexico ... sale process. Rick Gagliano , ... Blades said, "Our new name, AccuTec Blades, reflects the ...
(Date:9/1/2015)... --NOWDiagnostics Inc., based in Springdale, Ark. , ... Canada , a move that brings the company ... have greater access to information concerning their health. ... blood-based rapid tests that allow health care providers to ... ailments and diseases. ZBx Corporation, a Toronto ...
(Date:9/1/2015)... DALLAS , Sept. 1, 2015 UT ... and distinguished faculty members joined U.S. Representatives ... in a roundtable discussion on the 21 st ... biomedical research currently being considered by the ... faculty – including National Academy of Sciences members, department ...
Breaking Medicine Technology:AccuTec Blades, Inc. Announces Acquisition of Industrial Blades Division from Edgewell Personal Care Company 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 3U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 2U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 3U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 4U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 5
... Conn., May 15, 2012 /PRNewswire-iReach/ -- Global ... important Cambridge Healthtech Institute conferences: IMVACS – ... August 13 – 15, Cambridge, MA - The ... under one heading: the Seventh Annual Novel Vaccines, Design ...
... Labs, Inc. (OTCQB/OTCBB: GOVX), a biotechnology company that creates, ... results for the three months ended March 31, 2012 ... delighted with recent developments that have strengthened and advanced ... David Dodd. "Our Phase 1/2 therapeutic vaccine trial continues ...
Cached Medicine Technology:Attendees Save up to $350 on CHI Conferences This Summer by Registering Through Global Information 2GeoVax Labs Reports 2012 First Quarter Financial Results 2GeoVax Labs Reports 2012 First Quarter Financial Results 3GeoVax Labs Reports 2012 First Quarter Financial Results 4GeoVax Labs Reports 2012 First Quarter Financial Results 5GeoVax Labs Reports 2012 First Quarter Financial Results 6
... WideBiter Punch series facilitates fast and effective ... smooth, anatomically shaped meniscal rim. The flat, ... to access even the tightest joint spaces. ... Inc., 20 years of engineering experience in ...
... series facilitates fast and effective resection of ... shaped meniscal rim. The flat, crescent-shaped tip ... even the tightest joint spaces. Made in ... years of engineering experience in arthroscopy hand ...
... fast and effective resection of meniscal tears ... rim. The flat, crescent-shaped tip has an ... tightest joint spaces. Made in the U.S. ... engineering experience in arthroscopy hand instrument design ...
... facilitates fast and effective resection of meniscal ... meniscal rim. The flat, crescent-shaped tip has ... the tightest joint spaces. Made in the ... of engineering experience in arthroscopy hand instrument ...
Medicine Products: