Navigation Links
Key Protein Limits Damage of Heart Attack
Date:3/29/2008

Activating Gi compound in mice was important protective mechanism, researchers say

FRIDAY, March 28 (HealthDay News) -- A signaling protein called Gi plays a critical role in protecting the heart during a heart attack, say researchers at Thomas Jefferson University in Philadelphia.

It was already known that Gi increased activity in a failing heart, but it wasn't clear whether the protein was helping the heart adapt to damage or if it actually caused more heart cells to die.

In this study, the researchers created mice that lacked a working Gi gene, simulated a heart attack, and then restored blood flow to the heart. These mice suffered more heart damage than mice with a normally functioning Gi gene.

"It appears that in this setting, Gi is an important protective mechanism," team leader Walter Koch, a professor of medicine and director of the Center for Translational Medicine at Jefferson Medical College, said in a prepared statement.

"The heart wants to activate Gi and attempt to protect cardiac myocytes from dying. We found that in this acute setting, heart attacks are bigger when Gi is blocked," he said.

The study was published in the March 18 issue of Circulation.

Gi plays an important role in intracellular signaling, similar to a molecular switch, explained Koch. Gi is not a new drug target, but the activation of certain receptors (such as beta-2 adrenergic receptors) that also turn on Gi could be drug targets.

Koch said developing a "class-specific Gi inhibitor" is a vital step in learning more about Gi's role and behavior.

"We don't have to worry about what the receptor we are blocking; we're blocking a receptor that couples with Gi. We never had the tools before to tell if Gi activation was good or bad. We think that we can now begin to test the role of Gi in cardiac injury," Koch said.

More information

The American Heart Association has more about heart attack.



-- Robert Preidt



SOURCE: Thomas Jefferson University, news release, March 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... ... July 25, 2017 , ... Dr. ... Arbor University recently co-authored and published an article in the medical science journal ... Plexus Palsy. Both the article and the research that helped produce it, were ...
(Date:7/25/2017)... (PRWEB) , ... July 25, 2017 , ... Facing medical ... father Ezra Clark is taking advantage of a new benefit for employees that is ... means a lot that the company supports me and other employees as new parents. ...
(Date:7/24/2017)... ... 2017 , ... Engineers at the University of Maryland have invented an entirely ... electrical energy that the body uses. , In ordinary batteries the electrical energy, ... out of the battery is generated by moving positive ions from one end to ...
(Date:7/24/2017)... Houston, TX (PRWEB) , ... July 24, 2017 , ... ... $1000 student scholarship will be awarded for the fall semester to a deserving student. ... SignatureCare Emergency Centers Spring 2017 scholarship was awarded to Mariana Castillo who is a ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... (MCPS) have partnered together for a unique opportunity that helps high school girls succeed ... “Removing Barriers, Creating Opportunities.” Horizon Goodwill will host over 20 high school ...
Breaking Medicine News(10 mins):
(Date:7/20/2017)... 2017  Prime Therapeutics LLC (Prime) released this statement from ... today,s Institute for Clinical and Economic Review,s (ICER) public ... and value of abuse-deterrent formulations (ADF) of opioids. Prime was ... the meeting. "The ... to the use of abuse-deterrent formulations (ADF) in opioids in ...
(Date:7/14/2017)... DUBLIN , July 14, 2017 Endo International plc ... results on Tuesday, August 8, 2017.  Members of its senior management ... financial markets open at 8:30 a.m. ET. The ... (866) 497-0462, International (678) 509-7598, and the passcode is 45397076. ... A replay of the ...
(Date:7/13/2017)... July 13, 2017  New York City-based market research firm ... should be aware of.  From new products to new costs, ... in a recently completed study, Potential Pipeline Disruptors . ... 1.  Age-Driven Growth - True Impact ... aware of the impact the growing population and, to a ...
Breaking Medicine Technology: