Navigation Links
Key Anthrax Virulence Factor Discovered
Date:1/24/2008

Bacterial nitric oxide protects pathogen from immune system attacks

THURSDAY, Jan. 24 (HealthDay News) -- Researchers have discovered how the anthrax bacterium protects itself from the immune system's biochemical assault.

The results reveal not only a novel aspect of anthrax virulence, they also suggest a new target, known as bacterial nitric oxide synthase (bNOS), for fighting the pathogen, said study leader Evgeny Nudler, a professor of biochemistry at the New York University School of Medicine.

"That is the obvious continuation of our work," said Nudler, "to find small molecule inhibitors of bacterial nitric oxide synthase that would not touch its human counterpart. If we are lucky, we will find this inhibitor that would potentially work as an antibiotic."

One expert thought the finding could have therapeutic potential.

"bNOS can definitely be a therapeutic target," said Philip Tierno Jr., director of clinical microbiology & immunology in the Departments of Microbiology & Pathology at New York University Medical Center. "Clearly they showed that it should be a target, and if that somehow could be met, they may have knocked out the virulence of the organism, as they showed in the mouse model."

"But it may be more complicated than the model suggests, and there may be more factors at play than they suggest," Tierno added. "Things may not be a simple as it seems, but it's certainly a step in the right direction and should be explored, and might offer a solution, especially because anthrax could be a viable candidate for a terrorist."

The results were reported in this week's issue of the Proceedings of the National Academy of Sciences.

According to Nudler, this study stems from earlier research in which his team determined that bNOS (an enzyme that synthesizes nitric oxide) protects some bacteria from the stress of oxidizing chemicals, including the hyd
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. PharmAthene and Medarex Announce Additional $0.8 Million U.S. Government Appropriation for Continued Development of Anthrax Therapeutic Valortim(TM)
2. Nasal Anthrax Vaccine Proves Effective in Animal Study
3. Key to MRSA Virulence in Community Discovered
4. Lupus in women: New genetic risk factors identified
5. Extended work hours should factor into return to job after injury
6. American Heart Association President Urges Congress to Support Preventative Measures to Reduce Risk Factors for the Nations No. 1 Killer
7. 5 Factors Help Predict Psychosis in Children
8. New insight into factors that drive muscle-building stem cells
9. Trichloroethylene is a risk factor for parkinsonism
10. Risk factors for Parkinsons disease under study
11. Pilot error declines as factor in airline mishaps
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Key Anthrax Virulence Factor Discovered
(Date:7/30/2014)... 30, 2014 Pain Free Living web: ... bracelet for pain relief and improved performance. This new ... embedded in a silicone core that is sheathed in ... and is embedded with scalar energy and Schumann frequency ... Free Living has 12 years experience developing magnetic bracelets. ...
(Date:7/29/2014)... 30, 2014 Recently, iFitDress.com, a well-known wedding ... satin bridal gowns . Aside from this, it has ... up to 68 percent off. All of its old and ... The company’s sales representative says excitedly, “We are pleased to ... new range, there are a lot of amazing items. It ...
(Date:7/29/2014)... 30, 2014 VogueQueen.com, a well-known online ... the newest trends in garment fashion by providing graceful ... is selling an all-inclusive array of sexy dresses ... online, a lot of customers take price into consideration. ... That makes the purchase more affordable for all clients. ...
(Date:7/29/2014)... diet rich in soy may help feminine hearts, but ... in Menopause , the journal of The North ... the diet of women in Asia, produces the least ... to Asian migrants to North America, leads to just ... switching to soy from a Western diet after menopause ...
(Date:7/29/2014)... Daily Gossip indicates in its Natural Cure for Yeast Infection ... who is looking for an all-natural holistic cure for this ... Sarah Summer, says that her method is 100 percent natural. ... this is the reason why she was so determined in ... Natural Cure for Yeast Infection review indicates that Sarah ...
Breaking Medicine News(10 mins):Health News:Superior Magnetics Released New Magnetic Sports Bracelet for Pain 2Health News:Cheap Satin Bridal Gowns Recently Provided By Well-known Supplier iFitDress.com 2Health News:VogueQueen.com Now Provides Graceful And Sexy Lingerie Collection For August 2Health News:Soy may help women's hearts if they start early 2Health News:Natural Cure for Yeast Infection Review Reveals Sarah Summer’s Healing Method 2
... , VIRGINIA BEACH, Va., Jan. 11, 2010 Amerigroup ... report its earnings for the fourth quarter and the fiscal year ... Friday, February 19, 2010. At 8:30 a.m. Eastern Time on ... webcast to discuss earnings and other information. , To listen to ...
... , KNOXVILLE, Tenn., Jan. 11 TeamHealth ... that the underwriters of its recent initial public offering of ... an additional 1,995,000 shares of common stock from the Company ... intends to use the additional net proceeds of approximately $22.5 ...
... Jan. 11 The California Dental Association (CDA) ... charitable Dental Student Loan Repayment Grant Program. Two California ... each receive a maximum of $105,000 to help offset ... commitment to work in an underserved community. , ...
... to be part of the ,culture, at some centers, one ... Americans in nursing homes still get powerful antipsychotic medications, despite ... practice, two new studies show. , The practice can control ... U.S. Food and Drug Administration instituted a "black box" warning ...
... ... Corpus Christi and Austin, Texas areas. , ... San Antonio, TX (PRWEB) January 11, 2010 -- Physicians Health ... choices and benefits than original Medicare -- is pleased to announce it is partnering ...
... , SC AG McMaster to ... , WASHINGTON, Jan. 11 South Carolina Attorney ... general into the constitutionality of the health care reform bill ... press conference at 2:00 p.m. on Wednesday, January 13th, ...
Cached Medicine News:Health News:Amerigroup Corporation to Discuss Fourth Quarter and 2009 Year-End Earnings on February 19 2Health News:TeamHealth Announces Exercise of Over-Allotment Option for Previously Announced Initial Public Offering 2Health News:TeamHealth Announces Exercise of Over-Allotment Option for Previously Announced Initial Public Offering 3Health News:TeamHealth Announces Exercise of Over-Allotment Option for Previously Announced Initial Public Offering 4Health News:California Dental Association Foundation Awards More Than $200,000 in Community Service Grants 2Health News:Antipsychotics Still Widely Used in U.S. Nursing Homes 2Health News:Antipsychotics Still Widely Used in U.S. Nursing Homes 3Health News:Top-Rated Medicare Plan Now Offers Silver Life Fitness Program Free to its Members 2Health News:Top-Rated Medicare Plan Now Offers Silver Life Fitness Program Free to its Members 3
(Date:7/29/2014)... YORK , July 29, 2014 /PRNewswire-iReach/ -- ... the basis of products, methods, applications, end users, ... highest growth in the microbial identification market. This ... consumable costs (per test) and the time required ... and continuous technological advancements. Furthermore, genotypic methods have ...
(Date:7/29/2014)... , July 29, 2014 Regado Biosciences, ... focused on the Phase 3 clinical development of Revolixys™ ... antithrombotic drug system, today announced that it will hold ... Aug. 12, 2014, at 8:30 a.m. EDT to discuss ... Interested participants and investors may access the ...
(Date:7/29/2014)... , July 29, 2014  Landauer, Inc. (NYSE: ... environmental radiation measurement and monitoring, outsourced medical physics services ... results for the fiscal third quarter 2014 after the ... The Company will host a conference call for ... Central Time (10 a.m. Eastern Time). Investors may access ...
Breaking Medicine Technology:Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 2Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 3Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 4Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 5Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 6Regado Biosciences to Provide Second Quarter 2014 Financial Results and Corporate Highlights 2Regado Biosciences to Provide Second Quarter 2014 Financial Results and Corporate Highlights 3Landauer, Inc. Sets Date and Time for Announcement of Fiscal Third Quarter 2014 Results 2
... International, Inc. (Nasdaq: HTWR ; ASX: HIN), ... technologies that are revolutionizing the treatment of advanced heart ... to make an investor presentation at the UBS 2010 ... 12:30 pm EDT.  The conference will be held September ...
... KING OF PRUSSIA, Pa., Sept. 15 ... into a strategic alliance with Campbell Informatics, an integrated ... alliance of Tunnell, a leading life sciences industry consultancy, ... life sciences manufacturers, suppliers and regulators, is designed to ...
Cached Medicine Technology:HeartWare to Present at the UBS 2010 Global Life Sciences Conference 2Tunnell Consulting Forms Strategic Alliance With Ireland-Based Campbell Informatics 2
... The new Guidant VASOVIEW® HemoPro™ ... deliver a new level of ... for both the saphenous vein ... cut-and-seal capability, it lets you ...
Patient Monitor...
...
... or antepartum GBS results can be available in ... revolutionary in vitro diagnostic test is the first ... in the clinical lab and near-patient by non-laboratory ... 24 hours a day, 365 days a year. ...
Medicine Products: