Navigation Links
Ketamine Impairs Brain by Releasing Superoxide
Date:12/6/2007

Researchers claim finding could lead to new treatments for schizophrenia

THURSDAY, Dec. 6 (HealthDay News) -- Researchers say they have figured out how the drug ketamine impairs the brain, a finding they claim could lead to new treatments for schizophrenia.

The anesthetic/antidepressant triggers increased production of a toxic-free radical called superoxide and induces schizophrenia-like behavior in drug users, but that action can be blocked, say researchers at the University of California, San Diego, School of Medicine (UCSD).

The findings are published in the Dec. 7 issue of Science.

In this study with mice, the researchers discovered a link between an inflammatory enzyme complex (NADPH oxidase) and the dysfunction of certain brain neurons exposed to ketamine. Normally, NADPH is found in white blood cells circulating outside the brain, where it helps kill infections by producing superoxide.

"Because of NADPH oxidase's protective role in fighting infection, it was very surprising to find that the complex wears a second hat -- it is also critical for modulating signaling in the brain," study first author M. Margarita Behrens, of the geriatric medicine division at the UCSD School of Medicine, said in a prepared statement.

It was known that ketamine can impair inhibitory circuitry in the brain by blocking a receptor that controls neuron activity. But the UCSD team found that ketamine also greatly boosts the activity of NADPH, which results in further disruption of neuron signaling and impairment of brain circuitry involved in memory, attention and other important learning functions.

The researchers used ketamine to induce schizophrenia-like symptoms in mice and found that changes in the rodents' brains occurred in an area similar to where brain changes occur in people with schizophrenia.

When the researchers used an inhibitor to block the activity of NADPH, or a compound that wipes out superoxide, neurons in this brain area were protected.

"Our findings suggest that compounds that inhibit NADPH oxidase in the brain, without totally blocking its protective function of killing bacteria, could provide future therapies for schizophrenia or other diseases in humans that exhibit similar changes in neural circuitry," Behrens said.

More information

Mental Health America has more about schizophrenia.



-- Robert Preidt



SOURCE: University of California, San Diego, news release, Dec. 6, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Awake the Movie Highlights the Need for Goldilocks Anesthesia, Says Dr. Barry L. Friedberg, Developer of Bispectral Index (BIS) Monitored Propofol Ketamine Sedation, Now Trademarked as Minimally Invasive Anesthesia (MIA)(R)
2. Draining away brains toxic protein to stop Alzheimers
3. Vision restoration therapy shown to improve brain activity in brain injured patients
4. Clinical depression linked to abnormal emotional brain circuits
5. Brain imaging reveals breakdown of normal emotional processing
6. Brain cells work differently than previously thought
7. Vaccine Stops Alzheimers Brain Tangles
8. Research may unlock mystery of autisms origin in the brain
9. Scientists Spot Brains Free Will Center
10. Free will takes flight: how our brains respond to an approaching menace
11. Alcoholics With Cirrhosis Have More Brain Damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... May 2016 – Lips ... central to popular cosmetic improvement efforts. Record numbers of clients now ask about lip ... or pouty, says Kally Papantoniou, MD, of Advanced Dermatology P.C. , The ...
(Date:5/26/2016)... (PRWEB) , ... May 26, ... ... organization promoting quality-based imaging practices, is seeking nominations to serve on its ... diagnostic imaging. , “RadSite’s quality-benchmarking activities incorporate key process and ...
(Date:5/26/2016)... ... May 26, 2016 , ... In Madeira Beach Florida, a ... a single drawbridge, citizens formed an organization, Madeira Beach United, to oppose two development ... the small town center to a high rise urban environment. , According to the ...
(Date:5/26/2016)... ... 26, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star ... High blood pressure affects millions of people worldwide, and many patients use prescription ... heart disease, stroke, kidney disease, and hardening of the arteries. However, prescription medications ...
(Date:5/26/2016)... ... May 26, 2016 , ... With long-term experience ... President of Business Intelligence and Informatics, effective immediately. http://www.fluidedgeconsulting.com , As ... as a healthcare business and financial strategist for over 20 years. By ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016  Zymo Research ... for their new reference materials that help researchers ... sample collection to analyses. The rapid growth of ... for researchers to have standard methods to improve ... generated. Biases inherently exist at every step of ...
(Date:5/25/2016)... As illustrated by the Spring ... the numbers and momentum of cannabis in the US ... billions, more research and development push the sector forward. ... Legal Marijuana Markets Report  from from ArcView Market Research ... the increase in sector is attributed to adult use ...
(Date:5/25/2016)... , May 25, 2016 MedDay, a ... announces that an oral presentation entitled "High doses of biotin ... trial" will be given by Professor Ayman Tourbah , ... Congress of the European Academy of Neurology (EAN) in ... related disorders 3" will take place on Sunday, 29 May ...
Breaking Medicine Technology: