Navigation Links
Ketamine Impairs Brain by Releasing Superoxide
Date:12/6/2007

Researchers claim finding could lead to new treatments for schizophrenia

THURSDAY, Dec. 6 (HealthDay News) -- Researchers say they have figured out how the drug ketamine impairs the brain, a finding they claim could lead to new treatments for schizophrenia.

The anesthetic/antidepressant triggers increased production of a toxic-free radical called superoxide and induces schizophrenia-like behavior in drug users, but that action can be blocked, say researchers at the University of California, San Diego, School of Medicine (UCSD).

The findings are published in the Dec. 7 issue of Science.

In this study with mice, the researchers discovered a link between an inflammatory enzyme complex (NADPH oxidase) and the dysfunction of certain brain neurons exposed to ketamine. Normally, NADPH is found in white blood cells circulating outside the brain, where it helps kill infections by producing superoxide.

"Because of NADPH oxidase's protective role in fighting infection, it was very surprising to find that the complex wears a second hat -- it is also critical for modulating signaling in the brain," study first author M. Margarita Behrens, of the geriatric medicine division at the UCSD School of Medicine, said in a prepared statement.

It was known that ketamine can impair inhibitory circuitry in the brain by blocking a receptor that controls neuron activity. But the UCSD team found that ketamine also greatly boosts the activity of NADPH, which results in further disruption of neuron signaling and impairment of brain circuitry involved in memory, attention and other important learning functions.

The researchers used ketamine to induce schizophrenia-like symptoms in mice and found that changes in the rodents' brains occurred in an area similar to where brain changes occur in people with schizophrenia.

When the researchers used an inhibitor to block the activity of NADPH, or a compound that wipes out superoxide, neurons in this brain area were protected.

"Our findings suggest that compounds that inhibit NADPH oxidase in the brain, without totally blocking its protective function of killing bacteria, could provide future therapies for schizophrenia or other diseases in humans that exhibit similar changes in neural circuitry," Behrens said.

More information

Mental Health America has more about schizophrenia.



-- Robert Preidt



SOURCE: University of California, San Diego, news release, Dec. 6, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Awake the Movie Highlights the Need for Goldilocks Anesthesia, Says Dr. Barry L. Friedberg, Developer of Bispectral Index (BIS) Monitored Propofol Ketamine Sedation, Now Trademarked as Minimally Invasive Anesthesia (MIA)(R)
2. Draining away brains toxic protein to stop Alzheimers
3. Vision restoration therapy shown to improve brain activity in brain injured patients
4. Clinical depression linked to abnormal emotional brain circuits
5. Brain imaging reveals breakdown of normal emotional processing
6. Brain cells work differently than previously thought
7. Vaccine Stops Alzheimers Brain Tangles
8. Research may unlock mystery of autisms origin in the brain
9. Scientists Spot Brains Free Will Center
10. Free will takes flight: how our brains respond to an approaching menace
11. Alcoholics With Cirrhosis Have More Brain Damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... The Federal ... federallabs.org . The site houses a wealth of federal resources that businesses ... the process called technology transfer (T2). As a network of over 300 federal ...
(Date:2/8/2016)... Houma, LA (PRWEB) , ... February 08, 2016 ... ... Louisiana from offices in Houma, LA, celebrates the beginning of a new charity ... raised to assist Court Appointed Special Advocates (CASA). In the belief that children ...
(Date:2/8/2016)... Minn. (PRWEB) , ... February 08, 2016 , ... ... the BantamPro L top-load case packer for pouches, bags, and flow wrapped products ... to help co-packers and specialty product manufacturers step up to semi-automatic or fully-automatic ...
(Date:2/8/2016)... ... , ... Steve Helwig & Associates Insurance & Financial, serving the families of ... up with Citizens Opposed to Domestic Abuse in support of its efforts to provide ... victimized by the fear of violence in their own homes, donations may now be ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Delta Dental ... to help combat pancreatic cancer. , Gary D. Radine, who recently retired as president ... the American Cancer Society’s 2015 CEO of the Year , helped lead the ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016 ... the "Global Skin Protective Equipment Market 2016-2020" ... --> http://www.researchandmarkets.com/research/fqx6nz/global_skin ) has announced the addition ... 2016-2020" report to their offering. ... ) has announced the addition of the ...
(Date:2/8/2016)... 2016   Intarcia Therapeutics, Inc. today announced ... into the newly created role of Vice President, Head ... has two decades of leadership experience at leading pharmaceutical, ... academic medical center. Most recently Dr. Yee served as ... US Head Medical Officer at AstraZeneca, where he led ...
(Date:2/8/2016)... 8, 2016  The University of Michigan Health System ... that, as part of the development of four new ... hospitals in the U.S. to start using new top-of-the-line ... U-M,s chair of neurosurgery. --> Karin ... --> The BrightMatter technology from Synaptive Medical – ...
Breaking Medicine Technology: