Navigation Links
Ketamine Impairs Brain by Releasing Superoxide
Date:12/6/2007

Researchers claim finding could lead to new treatments for schizophrenia

THURSDAY, Dec. 6 (HealthDay News) -- Researchers say they have figured out how the drug ketamine impairs the brain, a finding they claim could lead to new treatments for schizophrenia.

The anesthetic/antidepressant triggers increased production of a toxic-free radical called superoxide and induces schizophrenia-like behavior in drug users, but that action can be blocked, say researchers at the University of California, San Diego, School of Medicine (UCSD).

The findings are published in the Dec. 7 issue of Science.

In this study with mice, the researchers discovered a link between an inflammatory enzyme complex (NADPH oxidase) and the dysfunction of certain brain neurons exposed to ketamine. Normally, NADPH is found in white blood cells circulating outside the brain, where it helps kill infections by producing superoxide.

"Because of NADPH oxidase's protective role in fighting infection, it was very surprising to find that the complex wears a second hat -- it is also critical for modulating signaling in the brain," study first author M. Margarita Behrens, of the geriatric medicine division at the UCSD School of Medicine, said in a prepared statement.

It was known that ketamine can impair inhibitory circuitry in the brain by blocking a receptor that controls neuron activity. But the UCSD team found that ketamine also greatly boosts the activity of NADPH, which results in further disruption of neuron signaling and impairment of brain circuitry involved in memory, attention and other important learning functions.

The researchers used ketamine to induce schizophrenia-like symptoms in mice and found that changes in the rodents' brains occurred in an area similar to where brain changes occur in people with schizophrenia.

When the researchers used an inhibitor to block the activity of NADPH, or a compound that wipes out superoxide, neurons in this brain area were protected.

"Our findings suggest that compounds that inhibit NADPH oxidase in the brain, without totally blocking its protective function of killing bacteria, could provide future therapies for schizophrenia or other diseases in humans that exhibit similar changes in neural circuitry," Behrens said.

More information

Mental Health America has more about schizophrenia.



-- Robert Preidt



SOURCE: University of California, San Diego, news release, Dec. 6, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Awake the Movie Highlights the Need for Goldilocks Anesthesia, Says Dr. Barry L. Friedberg, Developer of Bispectral Index (BIS) Monitored Propofol Ketamine Sedation, Now Trademarked as Minimally Invasive Anesthesia (MIA)(R)
2. Draining away brains toxic protein to stop Alzheimers
3. Vision restoration therapy shown to improve brain activity in brain injured patients
4. Clinical depression linked to abnormal emotional brain circuits
5. Brain imaging reveals breakdown of normal emotional processing
6. Brain cells work differently than previously thought
7. Vaccine Stops Alzheimers Brain Tangles
8. Research may unlock mystery of autisms origin in the brain
9. Scientists Spot Brains Free Will Center
10. Free will takes flight: how our brains respond to an approaching menace
11. Alcoholics With Cirrhosis Have More Brain Damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... Many families have long-term insurance that covers care for a family ... for care if the client has a cognitive impairment diagnosis. , “What this ... often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, owner ...
(Date:10/13/2017)... ... 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out ... free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting ... children of all ages; it is a non-competitive, non-timed event, which is all about ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed a ... and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been ... standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Centers for Disease Control and Prevention (CDC), influenza vaccination should take ... communities across Massachusetts , Connecticut , ... through the end of the month. *Some exclusions apply ... ... by the end of October, according to the Centers for Disease Control ...
(Date:10/2/2017)... Mich. , Oct. 2, 2017 Diplomat ... 8th Day Software and Consulting, LLC , and ... 8th Day Software, based in Tennessee ... LLC. 8th Day expands EnvoyHealth,s service offerings for health ... development. "In an ...
(Date:10/2/2017)... Fla. , Oct. 2, 2017  AllianceRx Walgreens ... company formed by Walgreens and pharmacy benefit manager Prime ... its new brand, which included the unveiling of new ... , as well as at a few other ... the new brand to patients, some of whom will ...
Breaking Medicine Technology: