Navigation Links
Ketamine Impairs Brain by Releasing Superoxide
Date:12/6/2007

Researchers claim finding could lead to new treatments for schizophrenia

THURSDAY, Dec. 6 (HealthDay News) -- Researchers say they have figured out how the drug ketamine impairs the brain, a finding they claim could lead to new treatments for schizophrenia.

The anesthetic/antidepressant triggers increased production of a toxic-free radical called superoxide and induces schizophrenia-like behavior in drug users, but that action can be blocked, say researchers at the University of California, San Diego, School of Medicine (UCSD).

The findings are published in the Dec. 7 issue of Science.

In this study with mice, the researchers discovered a link between an inflammatory enzyme complex (NADPH oxidase) and the dysfunction of certain brain neurons exposed to ketamine. Normally, NADPH is found in white blood cells circulating outside the brain, where it helps kill infections by producing superoxide.

"Because of NADPH oxidase's protective role in fighting infection, it was very surprising to find that the complex wears a second hat -- it is also critical for modulating signaling in the brain," study first author M. Margarita Behrens, of the geriatric medicine division at the UCSD School of Medicine, said in a prepared statement.

It was known that ketamine can impair inhibitory circuitry in the brain by blocking a receptor that controls neuron activity. But the UCSD team found that ketamine also greatly boosts the activity of NADPH, which results in further disruption of neuron signaling and impairment of brain circuitry involved in memory, attention and other important learning functions.

The researchers used ketamine to induce schizophrenia-like symptoms in mice and found that changes in the rodents' brains occurred in an area similar to where brain changes occur in people with schizophrenia.

When the researchers used an inhibitor to block the activity of NADPH, or a compound that wipes out superoxide, neurons in this brain area were protected.

"Our findings suggest that compounds that inhibit NADPH oxidase in the brain, without totally blocking its protective function of killing bacteria, could provide future therapies for schizophrenia or other diseases in humans that exhibit similar changes in neural circuitry," Behrens said.

More information

Mental Health America has more about schizophrenia.



-- Robert Preidt



SOURCE: University of California, San Diego, news release, Dec. 6, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Awake the Movie Highlights the Need for Goldilocks Anesthesia, Says Dr. Barry L. Friedberg, Developer of Bispectral Index (BIS) Monitored Propofol Ketamine Sedation, Now Trademarked as Minimally Invasive Anesthesia (MIA)(R)
2. Draining away brains toxic protein to stop Alzheimers
3. Vision restoration therapy shown to improve brain activity in brain injured patients
4. Clinical depression linked to abnormal emotional brain circuits
5. Brain imaging reveals breakdown of normal emotional processing
6. Brain cells work differently than previously thought
7. Vaccine Stops Alzheimers Brain Tangles
8. Research may unlock mystery of autisms origin in the brain
9. Scientists Spot Brains Free Will Center
10. Free will takes flight: how our brains respond to an approaching menace
11. Alcoholics With Cirrhosis Have More Brain Damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Stem cell ... years. The technology is so cutting edge, in fact, the U.S. Food and ... cell procedures. However, successful patient outcomes in certain clinical stem cell procedures have ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... South Bend’s ... proud to once again feature Heroes On The Water (HOW), a non-profit organization dedicated ... all new episode has series host ‘Mike D’ traveling to Lake Denmark, New Jersey, ...
(Date:2/22/2017)... ... 22, 2017 , ... A cylindrical “pipeline” used for treating ... reach ones, according to the results of a clinical trial announced Wednesday. , ... Ricardo A. Hanel, MD, PhD, neurovascular surgeon with Baptist Health and Lyerly Neurosurgery ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... Using the ... leads utilizing a simple online checklist. Over a period of just 24 months, thousands ... assistance of an online checklist called T.A.D. , “The internet is not getting quieter. ...
(Date:2/22/2017)... ... 22, 2017 , ... Becker’s Spine Review, the leading publication ... neurosurgeon Jay Jagannathan, M.D., as a “Spine Surgeon to Know.” http://www.beckersspine.com/spine-leaders/item/35348- . ... Michigan performing minimally invasive back surgery that often results in less post-operative discomfort ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... YORK , Feb. 22, 2017 ... the myocardial infarction partnering deals and agreements entered ... Read the full report: http://www.reportlinker.com/p03605670-summary/view-report.html ... report provides understanding and access to partnering deals ... healthcare companies. - Trends in partnering ...
(Date:2/22/2017)... 2017 Summary Provides understanding ... agreements entered into by the worlds leading healthcare ... Description The Global Atherosclerosis Partnering Terms ... access to partnering deals and agreements entered into ... - Trends in partnering deals - Top ...
(Date:2/22/2017)... 22, 2017 The top ... are Olympus Corporation, Nikon Corporation, and Leica Microsystems. ... in the overall market in 2015. The oligopolistic ... through result-oriented research and development activities and mergers ... focus on expanding their business to emerging economies ...
Breaking Medicine Technology: