Navigation Links
Ketamine Eased Depression in Treatment-Resistant Bipolar Disorder

MONDAY, August 2 (HealthDay News) -- The anesthetic drug ketamine helps ease depression in patients with treatment-resistant bipolar disorder, a new study finds.

Depressive symptoms are a major part of bipolar disorder, which affects about four percent of Americans at some point in their lives. There are several approved treatments for bipolar disorder, but some patients do not respond to these therapies.

Ketamine acts on the brain's glutamatergic system, which plays a role in information processing and memory formation. Recent research suggests that dysfunction in this brain system may contribute to bipolar disorder, noted Dr. Nancy Diazgranados and colleagues at the U.S. National Institute of Health.

Their study included 18 patients with bipolar depression that didn't improve when treated with the medications lithium or valproate. Two-thirds of the patients were on psychiatric disability and nearly all of them were unemployed.

The patients received an intravenous infusion of either ketamine or a placebo on two days two weeks apart. The order of the infusions was randomly assigned.

The patients' depressive symptoms were assessed before each injection and then 40, 80, 120 and 230 minutes, and one, two, three, seven, 10 and 14 days afterward. Within 40 minutes of receiving ketamine, the patients showed significant improvements in depressive symptoms compared to those who received the placebo. The improvements were most noticeable at day two and remained significant through day three.

At some point during the study, 71 percent of patients responded to ketamine and six percent responded to the placebo. No serious side effects were reported during the trial.

The study, published in the August issue of the journal Archives of General Psychiatry, provides evidence that the brain's glutamatergic system may play a role in bipolar disorder and that targeting it may lead to better treatments, the researchers wrote.

They also said that future research should explore how ketamine's rapid effect on depression can be maintained over the long-term.

Although ketamine has been used off-label as an experimental treatment for depression, it has not been approved by the U.S Food and Drug Administration for that use, according to the U.S. National Institutes of Health.

More information

The U.S. National Institute of Mental Health has more about bipolar disorder.

-- Robert Preidt

SOURCES: JAMA/Archives journals, August 2, 2010, news release; Ketamine Hydrochloride, U.S. National Institutes of Health; ketamine hydrochloride product label, Hospira Inc.

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. U of M study finds fast food chains have significantly decreased trans fats in cooking oils
2. Study shows universal surveillance for MRSA significantly decreased HAIs at PCMH
3. Mayo Clinic Proceedings: Sexual abuse survivors have increased of psychiatric disorders
4. Women with gestational diabetes have increased risk of recurrence in subsequent pregnancies
5. Clothing4all WOWs Yet Again With Customer Appreciation and Increased Sales
6. DTM Systems Is Pleased To Announce That Aaron Alsop Has Achieved The Project Management Professional Credential With The Project Management Institute
7. Lymphoma patients with cardiovascular disease have increased risk of cardiac hospitalization
8. Resource guide for internists released by ACP
9. Counseling increased mammography use among low-income women with health insurance
10. Minor kidney damage in people with type 1 diabetes leads to increased mortality
11. Pre-emptive pain regimen decreased opioid usage in patients undergoing robotic prostatectomy
Post Your Comments:
Related Image:
Ketamine Eased Depression in Treatment-Resistant Bipolar Disorder
(Date:11/25/2015)... ... November 25, 2015 , ... The holiday season is ... pleasing the palates of attendees is of the utmost importance. Whether you are ... get-together, give these recipes a try this holiday season. , Turkey Croquettes , ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... factory direct sauna parts and accessories. , Sauna accessories help improve the bather ... style and personality. From basic styles for the purist looking for simplicity in ...
(Date:11/25/2015)... ... 2015 , ... On November 10, 2015, Bohrer Brady, LLC filed a class ... of a home health care worker who provided companionship services for the elderly, ill ... employed by Humana, Inc., Humana at Home, Inc., and SeniorBridge Family Companies (CT), Inc. ...
(Date:11/25/2015)... Jacksonville, FL (PRWEB) , ... November 25, 2015 ... ... treatment center, is encouraging people across the country to celebrate their sobriety and ... invites people to post “before and after” photos this Thanksgiving with the hashtag ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... and athletic programs, launches new Wimbledon Athletics Facebook page to educate ... athletes for unsuspected cardiac abnormalities. About 2,000 people under the age of 25 ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... -- On Tuesday, November 24, 2015, the jury ... Medical Technology, Inc. for product liability and misrepresentation ... device, awarded $11 million in favor of Plaintiff ... three days of deliberations, the jury found that ... and unreasonably dangerous, and that Wright Medical made ...
(Date:11/25/2015)... SAN DIEGO , Nov. 25, 2015  Trovagene, ... molecular diagnostics, today announced that Chief Executive Officer Antonius ... at the 27 th Annual Piper Jaffray Healthcare ... Conference at the New York Palace Hotel in ... 2015 at 1:30 p.m. EST. Mr. Schuh will be ...
(Date:11/25/2015)... 25, 2015 --> ... glucose devices was valued at $11,171.1 million in 2014, ... of 5.7% during 2015 - 2022. The global market ... prevalence of diabetes. In addition, the increase in obese ... contributing to the growth of the market. Furthermore, technological ...
Breaking Medicine Technology: