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Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury
Date:6/11/2009

e fatigue is the lack of proven assessment tools. Researchers have been struggling for nearly a century to find ways to measure and diagnose cognitive fatigue. Common methods include self-reporting and objective assessments; however, the many limitations associated with both methods have hindered advancements in research and ultimately patient rehabilitation. This study offers a new and innovative paradigm to investigate brain activation during a cognitive task.

Dr. DeLuca was senior author of "The Neural Correlates of Cognitive Fatigue in Traumatic Brain Injury Using Functional MRI" (Kohl et al, Brain Injury 2009;23(5):420-32), which details how fMRI was utilized to assess cognitive fatigue in people with TBI while they were performing behavioral tasks. Researchers compared the readings of eleven healthy controls with those of eleven participants with moderate to severe TBI. The fMRI images illustrated increased brain activity in the patients with TBI, which indicates greater cerebral effort indicative of cognitive fatigue.

"This unique study expands our understanding of how TBI alters brain function and introduces a new approach for future studies," said Rodger DeRose, president and CEO of Kessler Foundation. "This is just one example of the advances in rehabilitation research being achieved at Kessler Foundation Research Center," DeRose added, "where our clinical scientists are making discoveries that improve quality of life for people with disabilities caused by TBI, spinal cord injury, stroke, multiple sclerosis and other chronic neurological and musculoskeletal disorders."

Kessler Foundation Research Center is a leader in the area of traumatic brain injury research. Funded by the National Institute on Disability and Rehabilitation Research, Kessler Foundation Research Center is one of 14 federally funded TBI model systems in the nation. Model Systems are comprehensive networks that promote
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