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Keppra XR(TM) Offers Convenient Dosing For People With Partial Onset Seizures
Date:11/5/2008

ion."

The immediate release tablet form of Keppra(R) (levetiracetam) was first approved by the FDA in 1999 as adjunctive therapy in the treatment of partial onset seizures in adults with epilepsy. Since then, Keppra(R) has become a leading antiepileptic drug in the U.S.

In addition, a new epilepsy therapy, Vimpat(R) (lacosamide) was approved by the FDA in late October 2008 and will be commercially available in early 2009. Vimpat(R) is approved for use as an add-on therapy for the treatment of partial-onset seizures in people with epilepsy who are 17 years and older.

About the Survey

The online survey was conducted by UCB. Email invitations were sent to 4,000 randomly selected email addresses from a database. Survey responses were limited to 500 complete responses in order to achieve a minimum 95 percent confidence interval, 5 percent margin of error and 50 percent proportion. The 500 responses were collected and validated, resulting in 451 usable respondents.

Keppra XR(TM) Important Safety Information

Keppra XR(TM) extended-release tablets are indicated as adjunctive therapy in the treatment of partial onset seizures in patients 16 years of age and older with epilepsy.

Keppra XR(TM) causes somnolence, dizziness, and behavioral abnormalities. The most common adverse reactions observed with Keppra XR(TM) in combination with other AEDs were somnolence and irritability.

The adverse reactions that may be seen in patients receiving Keppra XR(TM) are expected to be similar to those seen in patients receiving immediate-release Keppra(R) (levetiracetam) tablets.

Keppra(R) immediate-release tablets cause somnolence and fatigue, coordination difficulties, and behavioral abnormalities (e.g., psychotic symptoms, suicidal ideation, and other abnormalities), as well as hematological abnormalities. In adults experiencing partial onset seizures, the most common adverse reactions observed with Keppra(R) in combination wit
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