Navigation Links
Kentucky team inhibits Alzheimer's biomarkers in animal model by targeting astrocytes
Date:12/11/2012

LEXINGTON, Ky. (Dec. 10, 2012) A research team composed of University of Kentucky researchers has published a paper which provides the first direct evidence that activated astrocytes could play a harmful role in Alzheimer's disease. The UK Sanders-Brown Center on Aging has also received significant new National Institutes of Health (NIH) funding to further this line of study.

Chris Norris, an associate professor in the UK College of Medicine Department of Molecular and Biomedical Pharmacology, as well as a member of the faculty at the UK Sanders-Brown Center on Aging, is the senior author on a paper published recently in the Journal of Neuroscience, entitled "Targeting astrocytes to ameliorate neurologic changes in a mouse model of Alzheimer's disease." The first author on the article, Jennifer L. Furman, was a graduate student in the Norris laboratory during completion of the study.

The astrocyte is a very abundant non-neuronal cell type that performs absolutely critical functions for maintaining healthy nervous tissue. However, in neurodegenerative diseases, like Alzheimer's disease, many astrocytes exhibit clear physical changes often referred to as "astrocyte activation." The appearance of activated astrocytes at very early stages of Alzheimer's has led to the idea that astrocytes contribute to the emergence and/or maintenance of other pathological markers of the disease, including synaptic dysfunction, neuroinflammation and accumulation of amyloid plaques.

Using an animal model, researchers directly modulated the activation state of hippocampal astrocytes using a form of gene therapy.

Mice received the gene therapy at a very young age, before the development of extensive amyloid plaque pathology, and were assessed 10 months later on a variety of Alzheimer's biomarkers.

The research team found that inhibition of astrocyte activation blunted the activation of microglia (a cell that mediates neuroinflammation), reduced toxic amyloid levels, improved synaptic function and plasticity, and preserved cognitive function.

Norris and collaborators suggest that similar astrocyte-based approaches could be developed to treat humans suffering from Alzheimer's disease, or possibly other neurodegenerative diseases. This study provides proof of principle that therapeutically targeting astrocytes can be beneficial.

Norris has been named the principal investigator on a new NIH award totaling $1,498,423 over a period of 5 years, to continue this line of research on Alzheimer's disease.


'/>"/>

Contact: Allison Elliott
allison.elliott@uky.edu
University of Kentucky
Source:Eurekalert

Related medicine news :

1. Kentucky study finds common drug increases deaths in atrial fibrillation patients
2. InsuranceCalculator.net Now Provides Competitive Car Insurance Quotes To Kentucky Drivers
3. Feola, at University of Kentucky, receives NIH grant to study cystic fibrosis
4. New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
5. Molecule found that inhibits recovery from stroke
6. Bloodstream scavenger inhibits clotting without increased bleeding
7. Metabolic biomarkers for preventive molecular medicine
8. Tracking down smallest biomarkers
9. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
10. US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
11. Using biomarkers to identify and treat schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... NY (PRWEB) , ... April 28, 2017 , ... It's ... there are a number of illnesses that are unclear as to whether or not ... their heads. Bronchitis is one of these illnesses. So, FindaTopDoc took a look into ...
(Date:4/28/2017)... ... ... affects much more than energy – it also has mental and physical benefits. According to ... time, which can increase the risk of having a car accident. , This week ... to help you sleep better and feel better:, , Turn off ...
(Date:4/28/2017)... ... , ... The Radiology Business Management Association (RBMA) is pleased to ... election process has been in place since the RBMA was founded in 1968 with ... succeeds Jim Hamilton, MHA, CMM, FRBMA, as president. Dr. Dickerson the chief executive officer ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... America (UCAOA) and College of Urgent Care Medicine will host industry leaders for ... and speakers will help those in the industry adapt to the issues currently ...
(Date:4/28/2017)... ... April 28, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh ... Creator responds to and which He does not. Yisrayl says with so many titles ... the true name, but he says with a little Scripture, backed with a lot of ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a ... will be participating in the Deutsche Bank Securities 42nd ... Boston, Massachusetts on Wednesday, May ... Eastern Time. A live webcast of the ... website at http://investor.zimmerbiomet.com .  The webcast will be ...
(Date:4/20/2017)... 20, 2017  RXi Pharmaceuticals Corporation (NASDAQ: RXII), ... address significant unmet medical needs, today announced that ... consumer product development program, based on its proprietary ... Investigative Dermatology (SID) 76 th Annual Meeting.  ... the sciences relevant to skin health and disease ...
(Date:4/20/2017)... R.I. , April 20, 2017  CVS ... CVS), today unveiled a new store design to ... assortment of healthier food, health-focused products and expanded ... store to help customers discover new offerings. Together ... the next evolution of the customer experience at ...
Breaking Medicine Technology: