Navigation Links
Keeping stem cells pluripotent
Date:1/13/2014

While the ability of human embryonic stem cells (hESCs) to become any type of mature cell, from neuron to heart to skin and bone, is indisputably crucial to human development, no less important is the mechanism needed to maintain hESCs in their pluripotent state until such change is required.

In a paper published in this week's Online Early Edition of PNAS, researchers from the University of California, San Diego School of Medicine identify a key gene receptor and signaling pathway essential to doing just that maintaining hESCs in an undifferentiated state.

The finding sheds new light upon the fundamental biology of hESCs with their huge potential as a diverse therapeutic tool but also suggests a new target for attacking cancer stem cells, which likely rely upon the same receptor and pathway to help spur their rampant, unwanted growth.

The research, led by principal investigator Karl Willert, PhD, assistant professor in the Department of Cellular and Molecular Medicine, focuses upon the role of the highly conserved WNT signaling pathway, a large family of genes long recognized as a critical regulator of stem cell self-renewal, and a particular encoded receptor known as frizzled family receptor 7 or FZD7.

"WNT signaling through FZD7 is necessary to maintain hESCs in an undifferentiated state," said Willert. "If we block FZD7 function, thus interfering with the WNT pathway, hESCs exit their undifferentiated and pluripotent state."

The researchers proved this by using an antibody-like protein that binds to FZD7, hindering its function. "Once FZD7 function is blocked with this FZD7-specific compound, hESCs are no longer able to receive the WNT signal essential to maintaining their undifferentiated state."

FZD7 is a so-called "onco-fetal protein," expressed only during embryonic development and by certain human tumors. Other studies have suggested that FZD7 may be a marker for cancer stem cells and play an important role in promoting tumor growth. If so, said Willert, disrupting FZD7 function in cancer cells is likely to interfere with their development and growth just as it does in hESCs.

Willert and colleagues, including co-author Dennis Carson, MD, of the Sanford Consortium for Regenerative Medicine and professor emeritus at UC San Diego, plan to further test their FZD7-blocking compound as a potential cancer treatment.


'/>"/>
Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. SWEAT, a Highland Park/ University Park-Based Fitness Environment, Offers 10 Tips for Keeping Your New Year’s Fitness Resolution Alive
2. Dr. Oz: Keeping Your Cell Phone in Your Bra Can Cause Breast Cancer
3. Keeping Dogs Safe From Tainted Treats From China
4. Diet Doc Hormone Diets & Weight Loss Plans Launches Monthly Diet Newsletter Geared Toward Keeping Patients Informed with Interesting Health News, Diet Tips & Recipe Ideas
5. Peter Baker: 25 Years Dedicated to Keeping LIA at the Forefront of Laser Safety & Applications
6. Off Leash K9 Training: Celebrity Dog Trainer’s Advice for Keeping Your Dog Safe for the Holidays
7. Keeping emotions in check may not always benefit psychological health
8. Zane Benefits Publishes New Information on Keeping Healthcare Costs Down Without Cutting Benefits
9. MinuteHound Announces Latest Biometric Time Keeping System Designed for Hospitals and Patient Clinics
10. Keeping it local: Protecting the brain starts at the synapse
11. Dietpunch.com Announces Weight Loss Tips For Keeping Fat Off
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... 2017 , ... Peoples Health is pleased to announce that ... 1, 2016. Peoples Health, a Metairie-based Medicare Advantage company, serves more than 55,000 ... our provider network, and the addition will benefit our members in the Greater ...
(Date:1/17/2017)... NJ (PRWEB) , ... January 17, 2017 , ... Neil ... and financial planning assistance to communities throughout the region, is launching a charity drive ... Heart disease is by far the deadliest killer in America, and is responsible for ...
(Date:1/17/2017)... ... January 17, 2017 , ... Seceon ... cyber threats in real-time, today announced a strategic partnership with TechLab Security, ... Joining other Seceon partners, TechLab Security has become a strategic partner and a ...
(Date:1/17/2017)... CA (PRWEB) , ... January 17, 2017 , ... Many people make New Year’s resolutions ... Robert Mondavi is making it easier for people who want to kick off ... both new and existing patients. , These special offers include: , ...
(Date:1/16/2017)... ... January 17, 2017 , ... Recently, patients and staff ... Michigan, joined other volunteers and organizations in support of the annual Binder Park Zoo ... families dressed up in colorful costumes of all designs coming out to enjoy games, ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Calif. , Jan. 17, 2017  Edwards Lifesciences ... in patient-focused innovations for structural heart disease and critical ... the quarter ended December 31, 2016 after the market ... a conference call at 5:00 p.m. ET that day ... the conference call, dial (877) 407-8037 or (201) 689-8037.  ...
(Date:1/17/2017)... PUNE, India , Jan. 17, 2017  Market Research Future ... Global Endoscopy Devices Market is expected to reach USD 33.6 million ... 2016. Market Highlights ... The Global Endoscopy Devices Market has been examined as ... rate. Globally there is huge demand for endoscopy device in various ...
(Date:1/17/2017)... Research and Markets has announced the addition of the ... offering. ... global fluoropolymer market in the healthcare industry to grow at a ... Fluoropolymer Market in the Healthcare Industry 2016-2020, has been prepared based ... report covers the market landscape and its growth prospects over the ...
Breaking Medicine Technology: