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Keck School of Medicine of USC researchers find clue to how Hepatitis C virus harms liver
Date:12/12/2012

tion, Ou noted. About five percent develop liver cancer after 20 to 30 years.

Ou has been studying HCV for 20 years and Hepatitis B virus for 30 years. The most recent study reflects his long-term interest in understanding the interactions between these two viruses and their host cells, and how they cause liver cancer.

"The next step, which we've just begun, is to understand how the activation of the PI3K-AKT pathway allows the [HCV] virus to enter the cell," Ou said. "This research has led to the identification of a novel target for the development of new anti-HCV drugs. Compounds that disrupt the PI3K-AKT pathway are expected to prevent the virus from entering liver cells, causing the virus to disappear."


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Contact: Leslie Ridgeway
lridgewa@usc.edu
323-442-2823
University of Southern California - Health Sciences
Source:Eurekalert

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