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Keck Futures Initiative awards $1 million for 13 research projects

Multiscale biomedical imaging for autoimmune disease - $50,000
A multidisciplinary team will develop and combine new biomedical imaging methods in order to better detect, analyze, and track autoimmune diseases such as rheumatoid arthritis. The team will focus on producing advanced imaging tools that can probe molecules and peer inside both living cells and humans.

RAFAEL PIESTUN, University of Colorado, Boulder
LILIANA BORCEA, Rice University
Adaptive approach for imaging through a highly scattering volume using spatio-temporal waveform shaping and statistical algorithms - $75,000
Efficient optical imaging through highly scattering volumetric media is arguably the next frontier in imaging science, with wide implications in microscopy, security, biomedical analysis, neuroscience, and more. The goal of this project is to investigate adaptive imaging concepts, synergistically combining optical and mathematical methodologies to tackle this demanding imaging problem.

Building multiscale models of capillary regeneration from image-based RNA transcriptome analyses - $75,000
This project will establish an integrated approach to understand how capillaries form in tissues. Molecular-cell pathways will be interrogated via advanced hyperspectral imaging methods and a new class of erasable molecular imaging probes. Together, these tools will facilitate multiscale modeling efforts aimed at elucidating mechanisms governing capillary formation.

MARK SCHNITZER, Howard Hughes Medical Institute and Stanford University
TERI ODOM, Northwestern University
A technology platform for high-resolution biomedical imaging in live animals using genetically targeted nanoparticles - $100,000
Recently, genetics and nanotechnology have each provided powerful techniques for biomedical imaging in animal models of human disease. This research seeks to

Contact: Maureen O'Leary
National Academy of Sciences

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