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Kawasaki disease linked to wind currents
Date:11/10/2011

Kawasaki Disease (KD) is a severe childhood disease that many parents, even some doctors, mistake for an inconsequential viral infection. In fact, if not diagnosed or treated in time, it can lead to irreversible heart damage. After 50 years of research, including genetic studies, scientists have been unable to pinpoint the cause of the disease.

Now, surprising findings of an international team of scientists organized by Jane C. Burns, MD, professor and chief, Division of Allergy, Immunology, and Rheumatology at the University of California, San Diego School of Medicine's Department of Pediatrics and Rady Children's Hospital-San Diego, suggest that KD cases are linked to large-scale wind currents that track from Asia to Japan and also traverse the North Pacific.

"Our findings suggest an environmental trigger for Kawasaki disease that could be wind-borne," Burns said.

Signs of KD include prolonged fever associated with rash, red eyes, mouth, lips and tongue, and swollen hands and feet with peeling skin. The disease causes damage to the coronary arteries in a quarter of untreated children and may lead to serious heart problems in early adulthood. There is no diagnostic test for Kawasaki disease, and current treatment fails to prevent coronary artery damage in at least one in 10 to 20 children and death in one in 1,000 children.

While seasonality of the disease has been noted in many regions particularly in Japan, the country of highest incidence for KD the search for factors that might contribute to epidemics and fluctuations in KD occurrence has been elusive. A study of KD cases in Japan since 1970 showed three dramatic nationwide epidemics, each lasting several months and peaking in April 1979 (6,700 cases), May 1982 (16,100 cases) and March 1986 (14,700 cases). These three peaks represent the largest KD epidemic events ever recorded in the world.

To investigate a possible influence from large-scale environ
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Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

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