Navigation Links
Kawasaki disease and pregnant women
Date:3/6/2014

In the first study of its type, researchers at the University of California, San Diego School of Medicine have looked at the health threat to pregnant women with a history of Kawasaki disease (KD), concluding that the risks are low with informed management and care.

The findings are published in the March 6, 2014 online edition of the British Journal of Obstetrics and Gynaecology.

KD is a childhood condition affecting the coronary arteries. It is the most common cause of acquired heart disease in children. First recognized in Japan following World War II, KD diagnoses are rising among children in Asia, the United States and Western Europe. Predictive models estimate that by 2020 one in every 1,600 American adults will be affected by KD.

"A growing number of women with a history of KD are reaching child-bearing age, but there is little information available to guide their obstetrical care," said study author Jane C. Burns, MD, professor and director of the Kawasaki Disease Research Center at UC San Diego and Rady Children's Hospital-San Diego. "By and large, KD is virtually unknown among working obstetricians."

KD is currently diagnosed by a constellation of clinical signs, with supporting lab tests that indicate high levels of inflammation. These signs include abrupt onset of high fever, accompanied by four of five criteria, among them: widespread rash, cracked and fissured lips, "strawberry tongue," bloodshot eyes, lymph node enlargement and red, swollen hands and feet.

Without treatment, 25 percent of children with KD develop coronary artery aneurysms balloon-like bulges of heart vessels that may eventually result in heart attacks, congestive heart failure or sudden death. The condition can be treated with a high-dose of intravenous immunoglobulin and aspirin, reducing the risk of aneurysms to 5 percent. The long-term risk for adults with a history of KD in childhood is not known.

Senior study author John Gordon, MD, and colleagues conducted the first KD study of non-Japanese patients, and the first to explore the health risks to women with a history of KD and their offspring. They found that the health risks for mothers with no KD-related coronary artery damage were similar to the general population. For women with aneurysms, the risks were low with appropriate management and care.

"The main message is positive," said Burns. "Women who have had KD can successfully deliver to term without complications. C-sections are not necessarily indicated if they have aneurysms, they can labor normally, if their overall cardiovascular status is OK."

There is a genetic component to KD. The study found that two of the 21 children born to the 10 women with a history of KD also developed the disease. "There is clearly an increased risk in offspring," said Burns, "but the (study) numbers are small so we cannot really calculate a risk until there is a larger population of KD adults who have had children."


'/>"/>
Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Data from across globe defines distinct Kawasaki disease season
2. Researchers link Kawasaki Disease in childhood with increased risk of adult heart disease
3. Early detection helps manage a chronic graft-vs.-host disease complication
4. CWRU researchers find byproducts of bacteria-causing gum disease incite oral cancer growth
5. Panel recommends listing depression as a risk for heart disease
6. Acupuncture holds promise for treating inflammatory disease
7. REACT clinical trial supports new approach of accelerated treatment for Crohns disease
8. Neuropsychological assessment more efficient than MRI for tracking disease progression
9. Clemson researchers develop sticky nanoparticles to fight heart disease
10. Social norms strongly influence vaccination decisions and the spread of disease
11. Exon skipping prevents formation of toxic protein fragments in Huntingtons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2017)... ... ... total solar eclipse will occur across the U.S. on Monday, August 21, causing ... sun and Earth. This rare event will be magnificent to witness, but what does it ... the road during the total eclipse of the sun. , 1. Plan ahead. The eclipse’s ...
(Date:8/20/2017)... ... August 20, 2017 , ... ... HIPAA ComplyPAK™ Compliance Management System has assisted multiple clients in successfully passing ... Accountants, Service Organization Control Level 2 (AICPA SOC Level 2), and State Data ...
(Date:8/20/2017)... ... 20, 2017 , ... State Farm Neighborhood Assist® has named The Southern ... $25,000 grant. If the initiative wins, Gals Lead – Dream Queen Foundation’s signature teen ... area of St. Mary’s, Calvert and Charles Counties. The program could potentially impact nearly ...
(Date:8/20/2017)... CO (PRWEB) , ... August 20, 2017 , ... Are ... the same household? If so, you may be interested in participating in a ... purpose of this research is to understand more about the relational aspects of adults ...
(Date:8/19/2017)... ... August 19, 2017 , ... DMG Productions, producers of ... Group in an upcoming episode, slated to air fourth quarter 2017. Check your ... Aurum Group; a company committed to supporting dentistry using the most technologically advanced ...
Breaking Medicine News(10 mins):
(Date:8/18/2017)... Aug. 18, 2017  Nortis today announced the awarding of a $688K National ... the third year of a Small Business Innovation Research (SBIR)?Fast-track ... of Neurological Disorders and Stroke (NINDS).?  ... Nortis ParVivo Chip used ... ...
(Date:8/17/2017)... ANGELES , Aug. 17, 2017 MJAC2017 ... CBMJ – Canna Broadcast Media, today reveals its leading lineup. ... Isodiol International Inc., a global cannabis innovator specializing in the ... sponsor of the conference. MassRoots, Rambridge™ and The Green Organic ... Bay Inc. and Namaste Vapes™ as silver sponsors. ...
(Date:8/17/2017)... CAESAREA, Israel , August 17, 2017 /PRNewswire/ ... digital health Company with mobile health and big ... securities purchase agreements with domestic and non-U.S. investors ... common stock and shares of the Company,s newly ... private placement offerings. The Company expects to conduct ...
Breaking Medicine Technology: