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Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component
Date:4/13/2008

Karmanos researchers also discovered at a molecular level, TQ down regulated the normally active NF-B transcription factor and several of its downstream effector genes responsible for metastasis and cell invasion. NF-B is involved in cellular responses to stimuli such as stress, free radicals, ultraviolet irradiation and bacterial or viral antigens. It also plays a key role in regulating the immune response to infection, and is instrumental in the development of many chronic diseases, including cancer. These results suggest that an important molecular target could be down regulated by TQ in reversing chemoresistance, as well as the inhibition of invasion and metastasis of pancreatic cancer.

Further research is currently underway at Karmanos to obtain better clues for TQ's efficacy in future Phase I/II clinical trials. Thus, the research team at Karmanos is actively collaborating with physicians both at the Karmanos Cancer Center and the MD Anderson Cancer Center in Houston, Texas for assessing the clinical utility of TQ.

About the Barbara Ann Karmanos Cancer Institute

Located in mid-town Detroit, MI, the Barbara Ann Karmanos Cancer Institute is one of 39 National Cancer Institute-designated comprehensive cancer centers in the United States. Caring for more than 6,000 new patients annually on a budget of $216 million, conducting more than 700 cancer-specific scientific investigation programs and clinical trials, the Karmanos Cancer Institute is among the nation's best cancer centers. Through the commitment of 1,000 staff, including nearly 300 faculty members, and supported by thousands of volunteer and financial donors, the Institute strives to prevent, detect and eradicate all forms of cancer. John C. Ruckdeschel, M.D., is the Institute's president and chief executive officer. For more information call 1-800-KARMANOS or go to http://www.karmanos.org.

American Association for Cancer
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SOURCE Karmanos Cancer Institute
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