Navigation Links
Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component
Date:4/13/2008

SAN DIEGO, April 13 /PRNewswire-USNewswire/ -- The Barbara Ann Karmanos Cancer Institute researchers today presented, at the American Association for Cancer Research annual meeting in San Diego, CA, the potential benefits of Thymoquinone (TQ), a compound present in the oil of black seeds (Nigella sativa), in treating pancreatic cancer.

(Logo: http://www.newscom.com/cgi-bin/prnh/20071106/KARMANOSCANCERINSTITUTELOGO )

For centuries, these black seeds have been consumed in Asia, Africa and the Middle East to promote health and fight disease. TQ, an active component of the seeds, has been isolated for its promise as a chemopreventative agent. Pancreatic cancer cells currently have a high degree of inherent and acquired chemoresistance to standard chemotherapy agents Gemcitabine and/or Oxaliplatin, making these drugs only moderately effective.

"Our goal with this study was to increase the effectiveness of current pancreatic cancer treatments with a naturally occurring substance," said Sanjeev Banerjee, Ph.D., researcher, working under the leadership of Fazlul Sarkar, Ph.D., professor of pathology at the Karmanos Cancer Institute, Wayne State University. "We also explored the molecular mechanisms associated with TQ to promote better therapeutic outcomes."

Drs. Banerjee and Sarkar, along with Karmanos researchers Ramzi Mohammad, Ph.D. and Zhiwei Wang, Ph.D., pre-treated pancreatic tumor cells possessing different molecular signatures (HPAC, BxPC-3, Panc-1 and MDA Panc-28, COLO 357, L3.6pl), with TQ prior to administering Gemcitabine and Oxaliplatin. They found that TQ significantly enhanced the chemosensitivity of the tumor cells, making the Gemcitabine and Oxaliplatin agents more effective in treating the cancer. The TQ pre-treatment improved the drugs' effect on promoting cancer cell death and halting tumor cell growth.


'/>"/>

SOURCE Karmanos Cancer Institute
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. McCarty Cancer Foundation Awards $50,000 Grant for Myeloma Research Program at Karmanos Cancer Institute
2. Nominations for Outstanding Cancer Survivor Award Being Accepted by Karmanos Cancer Institute Through April 27
3. Kroger Pink Tag Campaign Raises $137,500 for Breast Cancer Research and Awareness at Karmanos Cancer Institute
4. Danialle Karmanos Work It Out Launches Dynamic Blog
5. Karmanos Cancer Center Most Preferred Hospital for Cancer Care According to 2007 Survey
6. Susan G. Komen For The Cure, Karmanos Cancer Institute, Local Hospitals Call on Policymakers to Address Injustice and Unfairness in Breast Cancer Incidence and Mortality
7. Susan G. Komen for the Cure, Karmanos Cancer Institute, Community Leaders, Breast Cancer Survivors and Activists to Gather at Forum and Call for Action on Breast Cancer
8. Penn researchers find targeted therapy combination overcomes treatment resistance in liver cancer
9. Researchers find disparities in depression among older Hispanics in US
10. Researchers Identify New Genetic Links to Psoriasis
11. Penn researchers discover modus operandi of heart muscle protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... WA (PRWEB) May 22, 2015 According to ... of all generations are equally as likely to worry about ... Millennials, 75% Gen X, 77% Boomers, 69% Silent Generation), which ... agree they are scared of aging, particularly Millennials (47%), Gen ... by Harris Poll in April, 2015 among more than 2,000 ...
(Date:5/22/2015)... West Hollywood, CA (PRWEB) May 22, 2015 ... at Sunset Plaza Dental announces that they ... in cosmetic, restorative and other dental treatments. At ... that interest them. Questions regarding what certain treatments ... can also be covered during this initial appointment. ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Wimbledon Health ... vascular, electrocardiogram (EKG), echocardiogram and NCV testing , ... a highly respected All American National athlete, to the ... I find the high level of testing and information ... athlete and their athletic trainers, this way they can ...
(Date:5/22/2015)... 22, 2015 In April 2006, Veatch ... past 9 years they have concentrated their focus to ... and Canada. Because of this growth and their goals ... offices in Denver, Colorado, Cleveland, Ohio, Houston, Texas and ... opening new dental offices, dental start ups, orthodontic practices, ...
(Date:5/22/2015)... May 22, 2015 In efforts to ... the section containing particular muscles stretches has been a ... 50% of stretches now complete, Chunk Fitness envisions a ... to be filmed and released at a later point ... found here: http://www.chunkfitness.com/stretches . , About the Company: ...
Breaking Medicine News(10 mins):Health News:New Study Reveals America’s Fear of Aging 2Health News:New Study Reveals America’s Fear of Aging 3Health News:West Hollywood Dental Office, Sunset Plaza Dental is Now Offering Complimentary Consultations 2Health News:Wimbledon Athletics Recruits Team USA Athlete 2Health News:Wimbledon Athletics Recruits Team USA Athlete 3
... Less than one fourth of physicians specializing in geriatrics, ... accurately predict the whether patients with heart failure are ... found. , The ability to determine whether patients ... clinical care, impacting key patient-care decisions such as therapeutic ...
... FRANCISCO, Calif., Feb. 11 Anesiva,Inc. (Nasdaq: ... announced an agreement granting,an exclusive license to ... Zingo(TM) (lidocaine hydrochloride monohydrate) powder,intradermal injection system ... Belgium and Luxembourg. Under the terms of ...
... benefit most have the poorest eating habits, , , MONDAY, ... blood pressure follow recommended dietary guidelines that help control ... people with hypertension actually appear to be eating worse ... the report published in the Feb. 11 issue of ...
... 11 - Depression is sometimes,viewed as a normal part ... likelihood of disability, placement in a nursing,home, and death. ... age,85 have the highest suicide rate in the United ... but when depressive symptoms,arise, it can be challenging not ...
... New research from the UC Davis M.I.N.D. Institute and ... in the blood of mothers of children with autism ... development. The study authors also found that the reaction ... regressive form of autism, which occurs when a period ...
... Product that can be ... Sprayed Directly into the Face, UNION, Ky., Feb. ... product for use after a,potential pathogenic exposure, MyClyns(TM), is available for ... a customer,service center and deployed regional product specialists to support the,MyClyns ...
Cached Medicine News:Health News:Doctors uncertain about approaches to care for heart failure patients, SLU study finds 2Health News:Anesiva and Sigma-Tau Announce Exclusive Marketing and Distribution Agreement for Zingo(TM) in Six European Countries 2Health News:Anesiva and Sigma-Tau Announce Exclusive Marketing and Distribution Agreement for Zingo(TM) in Six European Countries 3Health News:Most With High Blood Pressure Dont Follow Recommended Diet 2Health News:Depression in the Elderly is Complicated but Treatable, From the Harvard Mental Health Letter 2Health News:Some cases of autism may be traced to the immune system of mothers during pregnancy 2Health News:Some cases of autism may be traced to the immune system of mothers during pregnancy 3Health News:Some cases of autism may be traced to the immune system of mothers during pregnancy 4Health News:First Responders Acquire Revolutionary MyClyns(TM) Protective Spray 2Health News:First Responders Acquire Revolutionary MyClyns(TM) Protective Spray 3
(Date:5/22/2015)... , May 22, 2015 Research and Markets ... addition of the "Latest Regulations on Pharmaceutical ... to their offering. This is first ... a guidance on international multi-center clinical trials of ... has begun to be implemented on March 1, ...
(Date:5/22/2015)... China , May 22, 2015  China Nepstar ... "Company"), a leading retail drugstore chain in ... operated stores, today announced the resignation of Mr. ... for personal reasons, effective immediately. Ms. Rebecca Yingnan ... by the Company,s board of directors, effective immediately. Meanwhile, ...
(Date:5/21/2015)... , May 21, 2015 ... has announced the addition of the ... their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The ... and size the world market for Arthroscopy ... identifies trends impacting the market for these ...
Breaking Medicine Technology:2015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 3Analysing Arthroscopy Devices Markets Worldwide 2014-2020 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 3
... , , SANTA CLARA, Calif., Dec. ... diagnostic and services company, today announced that Dr. Ihor Gussak, ... join a distinguished roster of speakers, moderators and panelists at ... Assessment Summit. The Conference is scheduled for January 12 and ...
... YORK, Dec. 22 Delcath Systems, Inc. (Nasdaq: DCTH ... for primary and metastatic cancers to the liver, announced today ... Board, effective immediately. , "We formed our Scientific Advisory ... PHP System(TM) with insight from the leading experts in regional ...
Cached Medicine Technology:NewCardio to Sponsor and Present at 4th Annual Cardiac Safety Assessment Summit 2NewCardio to Sponsor and Present at 4th Annual Cardiac Safety Assessment Summit 3NewCardio to Sponsor and Present at 4th Annual Cardiac Safety Assessment Summit 4Professor Riccardo Lencioni Joins Delcath Systems' Scientific Advisory Board 2Professor Riccardo Lencioni Joins Delcath Systems' Scientific Advisory Board 3
... Albumin Cobalt Binding (ACB®) Test is a ... Albumin (IMA®) by measuring the cobalt binding ... sample. First identified in the early 1990s, ... in contact with ischemic tissue in the ...
... ELISA products for autoimmune testing feature single-well ... well as specific reflex tests including dsDNA, ... SS-A (Ro), SS-B (La), Scl-70 and Jo-1. ... a full line of products for Cardiolipins ...
... Diagnostics is a leading provider of immunofluorescence ... test menu that includes kits for autoimmune ... as miscellaneous conjugates and components. Our Impact ... assortment of substrates and kit sizes to ...
... Our ELISA products for autoimmune testing ... ELISAs, as well as specific reflex tests ... Sm, Sm/RNP, SS-A (Ro), SS-B (La), Scl-70 ... family includes a full line of products ...
Medicine Products: