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KalVista and JDRF form research partnership for novel treatment of diabetic eye disease
Date:1/9/2012

ter on validating plasma kallikrein as a potential therapeutic target for diabetic macular edema underscores JDRF's commitment to developing innovative approaches to prevent and treat this condition to save vision before it deteriorates," said Aaron Kowalski, Ph.D., assistant vice president of Treatment Therapies for JDRF.

KalVista's candidate will be selected from a series of novel small molecule plasma kallikrein inhibitors, which are advancing through pre-clinical development for the treatment of DME by delivery via intravitreal (IVT) injection into the eye. The pre-clinical studies being co-funded by JDRF will test whether administration of plasma kallikrein inhibitors by injection are likely to be safe and effective in improving symptoms of DME as well as in preserving visual acuity and slowing disease progression.

"JDRF is the leading global organization focused on research into diabetes and its complications and we are delighted it has recognized the potential of our novel approach to treating diabetic macular edema based on plasma kallikrein inhibitors," said Andrew Crockett, KalVista's CEO. "This is an exciting collaboration and we look forward to the added expertise they will contribute to the development of our lead programme."

"JDRF's goal is to have the greatest and fastest positive impact on individuals with type 1 diabetes, which is why we are working to accelerate the translation of novel discoveries in the lab, through clinical evaluation of safety and efficacy, and into commercial development," added Kowalski. "What makes our collaboration with KalVista so exciting is that we are gradually seeing this novel therapy, which could represent a whole new approach to treating DME, move from basic research discovery into a potential commercially viable drug with the help of JDRF funding."


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Contact: Joana Casas
mcasas@jdrf.org
212-479-7560
Juvenile Diabetes Research Foundation International
Source:Eurekalert

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