Navigation Links
KalVista and JDRF form research partnership for novel treatment of diabetic eye disease
Date:1/9/2012

Southampton, UK and New York, USA 09 January 2012 - KalVista Pharmaceuticals ("KalVista") and JDRF have formed a research partnership focused on a novel approach being developed by KalVista to preserve vision and slow the progression of diabetic eye disease. Diabetic eye disease is one of the most common and most serious complications in people with type 1 diabetes (T1D). JDRF will provide up to $2.2 million in milestone-based financial support and research expertise to KalVista. The goal of this partnership is to advance KalVista's lead pre-clinical candidate, a plasma kallikrein inhibitor, into human proof-of-concept clinical trials and to generate clinical data that would highlight its potential as an entirely new approach to treat diabetic macular edema (DME). DME is a leading cause of visual loss for people with T1D that involves swelling of the retina, which can lead to blurred vision and blindness.

Plasma kallikrein is an enzyme (a serine protease) that has been identified as a potential therapeutic target in people with diabetic retinopathy. Research has shown that it contributes to increases in blood vessel leakage and thickening of the retina. Previous JDRF-funded studies led by one of KalVista's co-founders, Edward Feener, Ph.D., Associate Professor of Medicine at Harvard Medical School and Joslin Diabetes Center, demonstrated that plasma kallikrein is increased and activated in the vitreous fluid of people with DME . This data suggests that chronic activation of plasma kallikrein increases blood vessel inflammation and permeability by generating the production of a hormone called bradykinin, which causes blood vessels to dilate or enlarge. Plasma kallikrein inhibitors are believed to reduce retinal vessel leakage by suppressing the chronic and excessive production of bradykinin.

"Diabetic eye disease is a high priority research area for JDRF. Our support of Dr. Feener's academic research over the years at the Joslin Diabetes Center on validating plasma kallikrein as a potential therapeutic target for diabetic macular edema underscores JDRF's commitment to developing innovative approaches to prevent and treat this condition to save vision before it deteriorates," said Aaron Kowalski, Ph.D., assistant vice president of Treatment Therapies for JDRF.

KalVista's candidate will be selected from a series of novel small molecule plasma kallikrein inhibitors, which are advancing through pre-clinical development for the treatment of DME by delivery via intravitreal (IVT) injection into the eye. The pre-clinical studies being co-funded by JDRF will test whether administration of plasma kallikrein inhibitors by injection are likely to be safe and effective in improving symptoms of DME as well as in preserving visual acuity and slowing disease progression.

"JDRF is the leading global organization focused on research into diabetes and its complications and we are delighted it has recognized the potential of our novel approach to treating diabetic macular edema based on plasma kallikrein inhibitors," said Andrew Crockett, KalVista's CEO. "This is an exciting collaboration and we look forward to the added expertise they will contribute to the development of our lead programme."

"JDRF's goal is to have the greatest and fastest positive impact on individuals with type 1 diabetes, which is why we are working to accelerate the translation of novel discoveries in the lab, through clinical evaluation of safety and efficacy, and into commercial development," added Kowalski. "What makes our collaboration with KalVista so exciting is that we are gradually seeing this novel therapy, which could represent a whole new approach to treating DME, move from basic research discovery into a potential commercially viable drug with the help of JDRF funding."


'/>"/>

Contact: Joana Casas
mcasas@jdrf.org
212-479-7560
Juvenile Diabetes Research Foundation International
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... , ... May 24, 2016 , ... Regenerative Medicine is ... in adult stem cell therapy technology, protocols and patient results as have been achieved ... to become a more accessible standard of care for patients worldwide. , As the ...
(Date:5/24/2016)... Linda, CA (PRWEB) , ... May 24, 2016 , ... ... will house the new adult hospital and expanded Children’s Hospital. Over 3,000 people looked ... 22. , Check out the event photo slidehsow. , During the program, ...
(Date:5/24/2016)... ... May 24, 2016 , ... Boyd Industries, a leading ... Unit® (CDU), a groundbreaking new product for pediatric dentistry , at AAPD 2016, ... San Antonio, TX May 26-29. The Concealed Delivery Unit keeps dental hand pieces and ...
(Date:5/24/2016)... ... 2016 , ... A newly released report reveals that improving life outcomes for ... both in face-to-face interactions and online. In “Heard, Not Judged – Insights into the ... use of mobile digital devices can be an effective tool to help boys and ...
(Date:5/24/2016)... ... May 24, 2016 , ... Growing in popularity, more ... more gluten-free products are available and easily accessible. Whether someone chooses to cut gluten ... to a certain diet, King Kullen Grocery stocks their shelves with many different gluten-free ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... the world , s first dual therapy ... intervention   OrbusNeich, a global company specializing ... its portfolio to include products to treat peripheral artery ... company,s first entry devices for lower limb and arteriovenous ...
(Date:5/24/2016)... HONG KONG , May 24, 2016 ... de COMBO ™ , la ... présentent des cathéters destinés à l,intervention portant ... artério-veineuse (FAV)   OrbusNeich, entreprise ... vasculaires permettant de changer la vie, a ...
(Date:5/24/2016)... -- Dutch surgeons have launched a ground-breaking medical app ... treat patients on a global scale. Medical professionals from ... and the US have already signed up for the ... a totally secure environment. Education  "Imagine a ... with a surgeon at Harvard to treat a bomb victim via ...
Breaking Medicine Technology: