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Kaiser Permanente Data Provides Strong Evidence for Continued Value of Combined Pap and HPV Testing
Date:3/24/2009

r's previously published protocol, this group of women would be scheduled for re-testing in 12 months to monitor the persistence of HPV infection. The study authors concluded, "In a general screening population, concerns about excessive HPV test positives among women aged 30 years and older are not borne out."

Investigators also revealed that among those women who tested positive for high-risk HPV infection with the digene HPV Test, patients in the age segments of 30-34 years (10.82 percent) and 35-39 years (8.03 percent) had the highest infection rates and also were the groups with the highest prevalence of CIN2/3, thus reinforcing the clinical benefit of reserving routine HPV testing for women age 30 and higher.

"These study results illustrate the benefits to large health systems of combined screening with the digene HPV Test and a Pap for all women age 30 and older, and dispels the notion that excessive numbers of women would require increased surveillance and follow-up when HPV testing is implemented," said Dr. Jim Godsey, Senior Vice President Research & Development North America for QIAGEN. "Some doctors have exercised caution using HPV testing out of now-disproven concern that they would have a lot of patients with Pap normal/HPV positive test results who would require counseling and follow-up. This study clearly demonstrates that this is not the case, and importantly shows cotest outcome rates within the very large and diverse patient population that Kaiser serves. This is good news to the clinical community who may have been overly anxious about the management of a large number of HPV positive, Pap normal test results. In fact, by identifying the women who test positive for infection with one of the cancer causing types of HPV -- and who are hence at greater risk of developing cervical disease -- clinicians can more effectively direct treatment and follow-up, potentially detecting more early stage disease
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SOURCE QIAGEN
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