Navigation Links
KS-herpesvirus induces reprogramming of lymphatic endothelial cells to invasive mesenchymal cells
Date:12/14/2011

signaling molecule downstream of Notch to induce EndMT. Moreover, the 3D KSHV-LEC transcriptome showed significant up-regulation of invasion related genes, that were found co-regulated in 3D KSHV-LECs and KS biopsies and suggesting that virus-induced EndMT may contribute to development of KS. The results further demonstrate that the 3D culture provides a permissive microenvironment for continuous viral replication and persistence, indicating the importance of virus-cell interactions for viral spread and thereby for oncogenesis.

"The unraveled molecular mechanisms can lead to identification of novel cellular targets for pharmacological control in virus-associated cancers", Dr. Ojala says.

This work is a collaboration between the research teams headed by Kaisa Lehti, Kari Alitalo, Lauri Aaltonen, and Sampsa Hautaniemi (all from University of Helsinki), Chris Boshoff (UCL Cancer Institute, University College London) and Adam Grundhoff (Heinrich Pette Institute-Leibniz Institute for Experimental Virology). The project involves scientists from two Academy of Finland National Centre of Excellence Programs, the Translational Genome-Scale Biology and Cancer Biology.


'/>"/>

Contact: Dr. Pivi Ojala
paivi.ojala@helsinki.fi
358-919-159-445
University of Helsinki
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Single gene mutation induces endometrial cancer
2. CSHL scientists discover how a tumor suppressor induces senescence and staves off cancer
3. 2009 H1N1 vaccine safe and induces robust immune response in people with asthma
4. Novel immune system-based gene therapy induces strong responses in metastatic melanoma, sarcoma
5. Discovery of a new reprogramming mechanism for tumor cells
6. Reprogramming brain cells important first step for new Parkinsons therapy
7. Pitt researchers discover gene mutation linked to lymphatic dysfunction
8. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
9. New study suggests stem cells sabotage their own DNA to produce new tissues
10. Attacking cancer cells with hydrogel nanoparticles
11. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... 01, 2015 , ... On March 19, 2015 Phil Valentine – the Executive Director of Connecticut ... Trail by stepping off Springer Mountain and heading north. Since that day, Phil has ... Connecticut and was greeted by friends and family. He visited CCAR and left an ...
(Date:7/31/2015)... ... July 31, 2015 , ... When the weather turned hot and warm-season ... type of sod called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) for short. ... introduction of this new type of sod, Super-Sod is giving away red Adirondack chairs ...
(Date:7/31/2015)... ... ... Ticket Down is a reliable source for authentic tickets for the 2015 ... festival will end on Sunday, August 2nd. , Music fans have traveled ... unique and unbelievably popular festival attracts the best in entertainment from around the world. ...
(Date:7/31/2015)... ... July 31, 2015 , ... Last week, ... GoodThreads. The store can be accessed by visiting http://www.curemeso.org/store . , “Our ... customizable. The best part: whenever a product is purchased, the Meso Foundation receives ...
(Date:7/31/2015)... ... July 31, 2015 , ... There’s no better way to enjoy ... comes time to cook the next meal, making July the most appropriate to be ... grilling tips and recipes. , Make the next cookout different than the ones in ...
Breaking Medicine News(10 mins):Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3
... 12 Repligen Corporation (Nasdaq: RGEN ), ... A products, announced today that the Company has received ... practices for manufacturing and quality systems. ISO certification ... manufacture of products and related services underlying its Protein ...
... and CEO, Scott Grisanti, Publishes Letter Outlining Strategy, ... 12 MedClean Technologies, Inc. (OTC Bulletin Board: ... for the onsite treatment and disposal of regulated ... CEO, Scott Grisanti, has published a letter to ...
... Inc., a premier,technology consulting firm, and Studio Velo, an ... the launch of a new bike club dedicated,to the ... good cause,the American Brain Tumor Association (ABTA). , ... The Studio Velo/Kovarus Cycling Club ...
... Health Integrated, the leading Targeted Population Health ... Analytics company, are partnering to jointly offer health ... targeted population management with advanced business intelligence. Mede,s ... and accurately informed about areas of particular concern ...
... and Ear Infirmary Joins International Observance To Draw Attention To ... In an effort to combat one of ... and the World Glaucoma Patient Organization have set March 12, ... The day will be marked by awareness and educational events ...
... Historic Perspective and Future DirectionsRALEIGH, N.C., Feb. 12 ... leading Clinical Research Organization, will host a prominent panel ... on February 25. Discussions will include case scenarios on ... are applicable to other fields of infectious disease research.The ...
Cached Medicine News:Health News:Repligen Announces ISO 9001:2000 Certification 2Health News:Repligen Announces ISO 9001:2000 Certification 3Health News:MedClean Technologies Inc. CEO Publishes Letter to Shareholders 2Health News:Biking for Fun, Sport, and Brain Tumor Awareness 2Health News:Biking for Fun, Sport, and Brain Tumor Awareness 3Health News:MedeFinance and Health Integrated Partner to Give Health Plans Competitive Advantage 2Health News:MedeFinance and Health Integrated Partner to Give Health Plans Competitive Advantage 3Health News:World Glaucoma Day Set For March 12, 2009 2Health News:World Glaucoma Day Set For March 12, 2009 3Health News:World Glaucoma Day Set For March 12, 2009 4Health News:PRA International Speaking Event: Rational Drug Design and Development in Infectious Diseases 2
(Date:7/30/2015)... , July 30, 2015  Unichem Pharmaceuticals ( ... one lot of Hydrochlorothiazide tablets 25 mg 1000-count bottle ... as a precautionary measure due to the identification of ... product. The risk associated with mistakenly ... is the increased probability of experiencing Clopidogrel,s side effects ...
(Date:7/30/2015)... Calif. , July 30, 2015  Amgen (NASDAQ: ... , partner and managing director of Warburg Pincus LLC, to ... pleased to welcome Fred Hassan and the deep, ... Amgen Board," said Robert A. Bradway , chairman and ... commitment to innovation will serve Amgen well." Mr. ...
(Date:7/30/2015)... -- Growth of the U.S. nonprescription market is primarily driven ... to the OTC market. Due to an increasingly favorable ... activity over the next five years with several all ... entering the market into existing categories. If ... those with low to moderate likelihood), the market is ...
Breaking Medicine Technology:Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3
... --  The Department of Environmental Protection will ... to help identify unregistered X-ray machines and bring ... a limited-time opportunity for medical providers to come ... Secretary Mike Krancer said. "The registration and inspection ...
... 2012 Telepharmacy is helping pharmacies extend services ... staffing shortages experienced by many rural health care ... allows for a pharmacy technician to be remotely ... state-of-the-art telecommunications technology to prepare prescriptions. ...
Cached Medicine Technology:Rural Health-Systems Benefit From Remote Pharmacy Technician Supervision 2Rural Health-Systems Benefit From Remote Pharmacy Technician Supervision 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: