Navigation Links
KS-herpesvirus induces reprogramming of lymphatic endothelial cells to invasive mesenchymal cells
Date:12/14/2011

Human tumor viruses contribute to 15-20% of human cancers worldwide. Kaposi's sarcoma herpesvirus (KSHV) is an etiological agent for Kaposi's sarcoma (KS) and two other rare lymphoproliferative malignancies. KS is the most common cancer in HIV-infected untreated individuals and remains a primary cause of cancer deaths in many subequatorial African countries as a result of the AIDS pandemic. Researchers at the Institute of Biotechnology and Research Programs Unit (Genome-Scale Biology) at the University of Helsinki have discovered a novel viral oncogenesis mechanism in which KSHV oncogenes co-opt cellular signaling pathways and modify the cellular microenvironment more permissive for viral replication.

The findings by the group of Research Professor Pivi Ojala (Institute of Biotechnology, University of Helsinki) demonstrates the first lymphatic-specific endothelial-to-mesenchymal transition (EndMT) induced by a human tumor virus. The virus-induced EndMT can contribute to development of KS by giving rise to infected, invasive cells, and providing the virus a permissive cellular microenvironment for efficient spread of the virus.

"This information can be used for developing targeted therapies to prevent or at least slow down the progression of KS in immunosuppressed patients", Dr. Ojala says.

By developing a novel three-dimensional (3D) cell model to better mimic the in vivo microenvironment, the researchers show that KSHV induces transcriptional reprogramming of primary lymphatic endothelial cells (LEC) to mesenchymal cells via EndMT, a process implicated in promoting tumor growth and cell invasiveness. Mesenchymal markers were found co-distributed in the same cells with KSHV in primary KS tumor samples, suggesting that the 3D culture in this work succeeds in recapitulating the known heterogeneity of the cell types in KS tumors.

The results also reveal a key enzyme in cancer cell invasion, MT1-MMP, as a previously unrecognized
'/>"/>

Contact: Dr. Pivi Ojala
paivi.ojala@helsinki.fi
358-919-159-445
University of Helsinki
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Single gene mutation induces endometrial cancer
2. CSHL scientists discover how a tumor suppressor induces senescence and staves off cancer
3. 2009 H1N1 vaccine safe and induces robust immune response in people with asthma
4. Novel immune system-based gene therapy induces strong responses in metastatic melanoma, sarcoma
5. Discovery of a new reprogramming mechanism for tumor cells
6. Reprogramming brain cells important first step for new Parkinsons therapy
7. Pitt researchers discover gene mutation linked to lymphatic dysfunction
8. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
9. New study suggests stem cells sabotage their own DNA to produce new tissues
10. Attacking cancer cells with hydrogel nanoparticles
11. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Recently, MagicQuinceaneraDresses.com, the popular online supplier ... of 2014 Quinceanera dresses . The company’s new ... look fashionable without paying a large amount of money. ... 57% off. , The company’s online shop has become ... special occasion outfits. In addition to exquisite Quinceanera dresses, ...
(Date:7/11/2014)... The American Association of Poison Control Centers ... commending Senator Bill Nelson (D-FL) for his introduction of ... July 10, 2014. Along with fellow Senate co-sponsors, this ... to enact rules requiring safer, child-resistant packaging for any ... co-sponsors of the bill include: Sen. Richard Blumenthal (D-CT), ...
(Date:7/11/2014)... Down reports that tickets to the Argentina vs. Germany ... between Brazil and Netherlands are in high demand. ... 12th at Estadio Nacional de Brasilia Mane Garrincha Brasila, Federal ... July 13th at Estadio Jornalista Mario Filho - Estadio do ... Cup are guaranteed to be authentic and are covered by ...
(Date:7/11/2014)... 11, 2014 Butler Mobility has recently updated ... Platform Lifts . Previously the two standard colors were ... beautiful earth tone colors as standard colors at no additional ... the home but will enhance the beauty of the stairway. ... home color scheme or individual décor. , The new selection ...
(Date:7/11/2014)... (HealthDay News) -- People with the lowest incomes may have ... disease (PAD), a new study suggests. People with PAD ... limbs, most often the legs. The condition causes leg pain ... throughout the body. People with PAD have a higher risk ... nearly 6,800 people with PAD who took part in the ...
Breaking Medicine News(10 mins):Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 3Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2Health News:Butler Mobility Products Announces Five New Standard Colors for Their Inclined Platform Lifts 2Health News:Poor More Prone to Leg Circulation Trouble 2
... HealthDay Reporter , THURSDAY, Feb. 24 (HealthDay News) -- A ... of the organ a day after birth, scientists report. ... that ways can be found to help the human heart ... heart for regeneration, but they,re somehow permanently switched off," said ...
... New findings by a University of Maryland-led team of ... for a human anti-malarial antibody or a scorpion ... environmentally friendly tool for combating malaria, at a time ... is declining. In a study published in the ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, Feb. ... decades ago, they are still pervasive in the United States ... a new study suggests. In fact, PCBs may account ... after IVF, the researchers said. "These findings may help ...
... redesign of the nation,s donor-liver distribution network developed by ... more people each year receiving the transplants they need. ... Management Science that donor livers currently are doled ... regard for geography and demographics, an arrangement that prevents ...
... State University has secured a $7.9 million award ... through increasing the African nation,s agricultural productivity, creating ... grant, funded by the U.S. Agency for International ... of Florida. The initiative employs trilateral cooperation, which ...
... California A new research study from Loma Linda ... may help contribute to heart health and disease prevention; ... of The Journal of Nutrition . ... as tocopherols, plus numerous phenolic substances, many of them ...
Cached Medicine News:Health News:Scientists Say Newborn Mice Can Regrow Damaged Hearts 2Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 2Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 3Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 4Health News:PCBs Might Be Linked to Failed IVF Attempts 2Health News:Redesign of US donor-liver network could boost transplants by several hundred per year 2Health News:Redesign of US donor-liver network could boost transplants by several hundred per year 3Health News:$7.9 million grant to improve food security, nutrition in Mozambique 2Health News:Antioxidants in pecans may contribute to heart health and disease prevention 2
(Date:1/15/2014)... -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging ... China,s orthopedic instrument industry has seen rapid ... from 3.28 billion yuan in 2006 to 9.85 billion ...
(Date:1/15/2014)... Jan. 15, 2014 As health officials across the Midwest ... Meijer pharmacies in Michigan will offer ... patients, enabling Meijer pharmacists to administer tests and, in some ... a physician participating in the study. The ...
(Date:1/15/2014)... Corporation (the "Company") (NASDAQ: CLSN ) today ... to purchase an aggregate of approximately $15 million of ... offering, led by a dedicated health care fund. ... these investors pursuant to which the Company agreed to ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... 2011 Omeros Corporation (NASDAQ: OMER ) ... in the Company,s Phase 3 clinical program evaluating OMS302 ... proprietary PharmacoSurgery™ products, is added to standard irrigation solution ... maintain intraoperative mydriasis (pupil dilation) and reduce postoperative pain ...
... YORK, Oct. 11, 2011 Reportlinker.com announces ... available in its catalogue: ... 2016 http://www.reportlinker.com/p0336530/Asia-Pacific-Orthopedic-Devices-Market-Outlook-to-2016.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Orthopedic ... Outlook to 2016 Summary ...
Cached Medicine Technology:Omeros Announces First Patients Treated in Phase 3 Clinical Program Evaluating OMS302 2Omeros Announces First Patients Treated in Phase 3 Clinical Program Evaluating OMS302 3Asia-Pacific Orthopedic Devices Market Outlook to 2016 2Asia-Pacific Orthopedic Devices Market Outlook to 2016 3Asia-Pacific Orthopedic Devices Market Outlook to 2016 4Asia-Pacific Orthopedic Devices Market Outlook to 2016 5Asia-Pacific Orthopedic Devices Market Outlook to 2016 6Asia-Pacific Orthopedic Devices Market Outlook to 2016 7Asia-Pacific Orthopedic Devices Market Outlook to 2016 8Asia-Pacific Orthopedic Devices Market Outlook to 2016 9Asia-Pacific Orthopedic Devices Market Outlook to 2016 10Asia-Pacific Orthopedic Devices Market Outlook to 2016 11Asia-Pacific Orthopedic Devices Market Outlook to 2016 12Asia-Pacific Orthopedic Devices Market Outlook to 2016 13Asia-Pacific Orthopedic Devices Market Outlook to 2016 14Asia-Pacific Orthopedic Devices Market Outlook to 2016 15Asia-Pacific Orthopedic Devices Market Outlook to 2016 16Asia-Pacific Orthopedic Devices Market Outlook to 2016 17Asia-Pacific Orthopedic Devices Market Outlook to 2016 18Asia-Pacific Orthopedic Devices Market Outlook to 2016 19
Colibri style with 1.5 mm long angled tip and 0.12 mm teeth. Serrated handles with polished finish....
Curved shafts with 3.5 mm angled platform and dull finish. Wide serrated handle with dull finish....
Straight shafts with 4 mm jaws. Serrated handle with dull finish. Jaws straight....
Double-ended. 10 mm sickle shaped blade. 27 mm blunt, curved double-edged blade....
Medicine Products: