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KLRI Releases 3rd Annual Report On Year's Top Longevity Research Findings
Date:5/12/2009

of postmenopausal women taking osteoporosis medication, have clinically low levels of vitamin D.

Oxidation, inflammation and insulin resistance. These are the "three horsemen of aging," believed to underlie nearly all age-related diseases and processes. Current work at KLRI includes a study to see if insulin sensitizers can reduce inflammation and oxidative stress. Elsewhere in the country, researchers are investigating the role of nutrition in stemming oxidation, inflammation and insulin resistance, finding that powerful plant-based antioxidants called polyphenols can prevent and reverse the effects of aging on memory brain cells and function.

Telomeres and insulin resistance. Telomeres are caps on the end of a cell's chromosomes that help keep chromosomes stable, just as the cap on a pen prevents ink from leaking. With time, however, the telomere shrinks. The shorter the telomere, the worse the cell functions and the closer it is to death. New research suggests that, in addition to age, being overweight or obese can wreak havoc on telomere length even in your twenties, thanks to insulin resistance.

Physical fitness and exercise training. To learn more about the benefits of exercise in preventing age-related declines, KLRI researchers have begun a study to measure the response of fit and unfit older men and women to two acute stressors: a blood pressure test, which increases oxidative stress, and a psychological test, which increases neuroendocrine stress, releasing inflammatory chemicals. Researchers will also look for any link between oxidative stress and neuroendocrine responses.

Calorie restriction. Numerous studies have found that restricting an animal's calories by 25 to 30 percent can extend their lifespan. A five-year trial called CALERIE (Comprehensive Assessment of Long-term Effects of Restricted Intake of Energy), which involves 250 healthy voluntee
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SOURCE Kronos Longevity Research Institute
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