Navigation Links
KEAP1 Keeps major cancer-promoting protein at bay
Date:10/9/2009

emonstrated that the presence of KEAP1 inhibits the NF?B signaling pathway and then conducted a series of experiments to find out how that happens. They found that depletion of KEAP1 leads to the accumulation of IKK, and then discovered that the tumor suppressor binds to a specific site on IKK, capturing it to feed it to the proteasome.

Hung likens this snatching of IKK to plucking stuffed animals with a mechanical claw out of an arcade game, imagery that wound up on the cover of Molecular Cell.

KEAP1 is a ubiquitin ligase that attaches to the target protein and works in a complex with another protein, CUL3, that connects the ubiquitins to the bound protein.

The team analyzed both KEAP1 and CUL3 expression in the tumors of 119 breast cancer patients and correlated the findings to overall survival. They found that underexpression of KEAP1 alone was associated with poor survival. Patients with strong expression of both KEAP1 and CUL3 had an 80 percent survival rate at five years while those with little expression of either had a 43 percent 5-year survival rate.

Next, they sequenced KEAP1's genes in 26 cancer lines (18 breast, four liver, four lung) and in 119 primary tumors (17 breast, 78 liver, 13 lung, 11 colon) and found two functional genetic mutations that shut down the protein's ability regulate IKK. The mutations affected the portion of the protein that binds to IKK.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Exercise During Pregnancy Keeps Newborn Size Normal
2. Brain Training Keeps Older Drivers Safe Behind the Wheel
3. Peripheral Arterial Disease: Simple Quiz Keeps You Circulating
4. Good News for Elderly: Happiness Keeps Growing
5. Healthy Diet, Exercise Keeps Mind Sharp As You Age
6. Social Activity Keeps Elders Young, Agile
7. Stigma Keeps Teens From Depression Treatment
8. Drug Combo Keeps Kidney Artery-Vein Grafts Viable
9. Stress Keeps Americans Tossing and Turning
10. Diabetes Keeps Rising Among U.S. Adults
11. Simple Exercise Keeps Brain at Top of Its Game
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
KEAP1 Keeps major cancer-promoting protein at bay
(Date:11/27/2014)... An inventor from Buffalo, N.Y., knows ... life, and she wants to lessen its impact. "After ... decided that there needed to be a way to ... to use and producible in design variations, the End ... areas throughout the day. It avoids bad odors, as ...
(Date:11/27/2014)... New York (PRWEB) November 27, 2014 ... ) have been filed in a consolidated litigation ... LLP reports. , Documents recently updated in ... records included in the state proceeding, all of ... bipolar disorder and other psychiatric conditions. Many of ...
(Date:11/27/2014)... WEDNESDAY, Nov. 26, 2014 (HealthDay News) -- Most babies ... a cold, the U.S. Food and Drug Administration says. ... be given to children younger than 2 because they ... agency warned. American adults average about three colds ... children get a cold, parents might want to give ...
(Date:11/27/2014)... (HealthDay News) -- Thanksgiving meals can pose a challenge ... an expert says. Many traditional Thanksgiving dishes -- ... -- are gluten-free, but "when it comes to pies, ... considered," Dr. Anca Safta, director of the Gluten and ... Center in North Carolina, said in a center news ...
(Date:11/27/2014)... The founders of VIM & VIGR, a company ... compression socks, are proud to announce the debut of their ... Pressure (TM) knitting technology that is designed to increase the ... to adding flair and style to a product that has ... eye of a writer at The New York Times ...
Breaking Medicine News(10 mins):Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 2Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 3Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 4Health News:Steer Clear of Cold Meds for Babies, FDA Advises 2Health News:Expert Shares Gluten-Free Thanksgiving Tips 2Health News:VIM & VIGR Announces Launch of Men’s Line of Compression Socks 2
... Satisfaction Can Lead to Relationship, Quality-of-Life ... ... Leading sexual wellness experts,who attended a satellite symposium of the American ... agreed that,better intimacy can lead to better relationships and ultimately, better,overall ...
... threat, study finds, , , WEDNESDAY, Nov. 12 (HealthDay News) -- Whether ... you have a higher risk of dying than someone of normal ... to collect their weight around the middle -- apple-shaped -- face ... tends to settle in their hips and thighs -- pear-shaped. ...
... Medical Simulation Corporation (MSC),announces a new partnership with the ... and education services for USF Health hospital partners and ... education. The MSC SimSuite Education Center is located at ... , "MSC is excited to partner with USF Health ...
... cost-containment. , ... Alexandria, VA (Vocus) November 12, 2008 ... Chain Drug Stores (NACDS) Steven C. Anderson, IOM, CAE issued a ... Finance Committee Chairman Max Baucus (D-MT) today:, , , , ,“It ...
... that Hydrates and Soothes Young Throats Now Available,Across ... As cough and cold season,rapidly approaches, Integrated ... and nutrition products has launched its newest product,in ... product is a perfect choice for parents who ...
... industry award for 2008, WASHINGTON, Nov. ... of furniture for healthcare environments, today announced ... Nightingale Award at the,annual Healthcare Design 08 ... workspace solution, SYNC(TM)., (Photo: http://www.newscom.com/cgi-bin/prnh/20081112/AQW138 ...
Cached Medicine News:Health News:Experts at American Society for Reproductive Medicine (ASRM) Satellite Symposium Reach Consensus: Better Intimacy = Better Overall Well-Being 2Health News:Experts at American Society for Reproductive Medicine (ASRM) Satellite Symposium Reach Consensus: Better Intimacy = Better Overall Well-Being 3Health News:Excess Weight Ups Risk of Death, No Matter Where It Collects 2Health News:Medical Simulation Corp. announces partnership with University of South Florida 2Health News:As Chairman Baucus Outlines Vision for Healthcare Reform, NACDS Emphasizes Pharmacy's Essential Role in Any Successful Overhaul 2Health News:Integrated Beverage Group Launches Children's Throat Cooler(R) in Canada 2Health News:Integrated Beverage Group Launches Children's Throat Cooler(R) in Canada 3Health News:Nurture(R) by Steelcase Wins Second Consecutive Nightingale Award for SYNC(TM) Caregiver Workspace Solution 2Health News:Nurture(R) by Steelcase Wins Second Consecutive Nightingale Award for SYNC(TM) Caregiver Workspace Solution 3
(Date:11/26/2014)... A hernia is condition in which a tissue, ... of a weak muscle area. Obesity, poor nutrition, smoking, and ... causes of hernias. There are several types of hernia such ... is when part of the abdominal tissue/organ protrudes into the ... of the umbilicus. A hiatal hernia is when a portion ...
(Date:11/26/2014)... NEW YORK and LONDON ... distributor of market intelligence, MarketResearch.com is pleased to announce ... Research and Consultancy focusing on the active pharmaceutical ingredient ... Research visit: http://www.marketresearch.com/land/publisher.asp?vendorid=4023&progid=86891 . In ... Market – Forecast to 2020 , ...
(Date:11/26/2014)... YORK , Nov. 25, 2014  Medtronic,s ... Covidien has been widely discussed in the ... it,s also creating a stronger leading player in ... to Kalorama Information.  The healthcare market research firm ... systems will feature a diverse set of solutions ...
Breaking Medicine Technology:Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 2Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 3Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 4MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 3Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3
... from a 52-week phase 3,study (LEADTM 3) of ... once-daily,human GLP-1 analog, were published online today in ... alone, produces statistically,significant and sustained improvements in blood ... as compared with glimepiride, a widely used,oral anti-diabetic ...
... Calif., Sept. 25 Neurobiological,Technologies, Inc. (NTI(R)) (Nasdaq: ... symptomatic intracranial hemorrhage in an earlier European,trial of ... ischemic,stroke may be minimized with avoidance of prolonged ... pressure entry criteria., The data, presented today ...
Cached Medicine Technology:Data from One-Year Liraglutide Phase 3 Study Published Online in The Lancet 2Data from One-Year Liraglutide Phase 3 Study Published Online in The Lancet 3Analysis of Earlier European Stroke Trial Supports Treatment Regimen for Viprinex(TM) in Current International Phase 3 Clinical Trials 2Analysis of Earlier European Stroke Trial Supports Treatment Regimen for Viprinex(TM) in Current International Phase 3 Clinical Trials 3Analysis of Earlier European Stroke Trial Supports Treatment Regimen for Viprinex(TM) in Current International Phase 3 Clinical Trials 4
Shoulder rasp...
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
85 left angled suture passer....
45 right angled suture passer....
Medicine Products: