Navigation Links
K-State scientist receives grant from National Institutes of Health to research cataracts
Date:7/14/2009

Research at Kansas State University is investigating the molecular composition of cataracts in hopes of developing a nonsurgical method to prevent or reverse the eye disease.

Cataracts, a clouding of the eye lens, are the leading cause of blindness in the world, according to the National Institutes of Health. Currently, surgery to remove and replace the cloudy eye lens is the only recommended method for restoring sight.

Larry Takemoto, a university distinguished professor of biology at K-State, has received nearly $500,000 from the National Institutes of Health to study the changes of protein interactions in the lens of the eye, which are believed to trigger cataracts.

"Presently, there is no known drug that can reverse or stop cataracts," Takemoto said. "By understanding the nature of the protein interactions on a biochemical level, we hope it will be possible in future studies to screen various drugs for their ability to inhibit or reverse the abnormal processes that cause cataracts."

In a healthy eye, a delicate and balanced interaction of proteins is normal and allows the lens to retain its transparency and ability to focus light. However, Takemoto's prior research suggests that changes in these interactions result in fluctuations of protein concentration. A change in concentration cause proteins to clump together, forming the cataract, and thus decreasing lens transparency. He has been collaborating with Chris Sorensen, university distinguished professor of physics at K-State, regarding theoretical aspects of this interaction.

"We think that the proteins have very specific interactions amongst themselves, and that cataracts result from changes in these interactions, leading to lens opacity," Takemoto said. "My laboratory has developed a methodology to study these interactions and their possible changes during the cataractous formation."

Takemoto is using a technique known as microequilibrium dialysis to measure protein interactions in a normal eye versus a cataractous eye. This process is normally used to study the interaction of smaller organic compounds; however Takemoto's lab will be the first to use it to study the interactions of proteins.

In microequilibrium dialysis, a mixture of two different types of proteins is put into one chamber, separated from another chamber by a filter that will only allow the passage of one type of protein. Over time, the protein concentrations in the chambers equalize, and if an interaction occurred, then the proteins should bind to one another.

"This technique allows us to both detect and quantitate possible changes in these interactions for the first time, under true equilibrium conditions," Takemoto said. "This study will establish the presence of interactions and will determine whether these interactions are altered during cataractogenesis."


'/>"/>

Contact: Larry Takemoto
takemlj@k-state.edu
785-532-6636
Kansas State University
Source:Eurekalert

Related medicine news :

1. K-State Veterinarian Says Although Exotic Pets Can Be Great Companions, There Are Health Factors That Can Affect Both the Animal and Humans
2. Strategies to Rein in Epidemics Need to be Retooled for Rural Populations, Say K-State Engineers Using Computers to Model Disease Outbreaks in Rural Areas
3. K-State Researchers and Their Partners Making it Easier for Rural Kansans of All Ages to Stay Healthy Despite Limited Access to Facilities Like Bike Trails, Gyms
4. K-State professor awarded $1.48 million to study LASIK complictions
5. K-State Researcher Finds That the 1918 Spanish Flu Virus Can Infect Swine and Resulted in Current Lineage of H1N1 Swine Influenza Viruses
6. K-State engineers create DNA sensors that could identify cancer using material only one atom thick
7. K-State Psychologist Studies Ways to Improve Soldiers Work-Life Relationship
8. K-State helps nursing home staff become comfortable with residents sexual expression
9. K-State Veterinarian Discusses Treating Dogs With Cushings Disease
10. K-State and Kansas Health Foundation Team Up to Promote One Health Kansas
11. K-State Trauma Researcher Says Being Prepared, Taking Action Are Vital in Preventing Tragedies Like the One at NIU
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join ... wage raise to $12 an hour by 2020 and then adjusting it yearly to increase ... of the minimum wage, assure the wage floor does not erode again, and make future ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of ... Farma Brasil as the company,s second affiliate in Latin America . ... ... Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: